INT126476

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 19.01
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
macrophage 1
neural tube 1
kidney 1
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 88 100.00 Very High Very High Very High
cva 3 98.30 Very High Very High Very High
agonist 13 84.28 Quite High
nociceptor 1 80.88 Quite High
Multiple sclerosis 4 79.80 Quite High
Inflammation 46 77.60 Quite High
rheumatoid arthritis 1 75.68 Quite High
Kinase C 36 71.92 Quite High
Hippocampus 35 69.28 Quite High
fibrosis 1 69.16 Quite High
Disease Link Frequency Relevance Heat
Cancer 1139 99.44 Very High Very High Very High
Von Hippel-lindau Syndrome 1 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 675 99.14 Very High Very High Very High
Hypoxia 627 99.12 Very High Very High Very High
Increased Venous Pressure Under Development 4 99.04 Very High Very High Very High
Metastasis 1012 98.72 Very High Very High Very High
Cv General 3 Under Development 3 98.30 Very High Very High Very High
Renal Cancer 15 98.26 Very High Very High Very High
Injury 32 97.96 Very High Very High Very High
Reprotox - General 1 19 95.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro, the CXCR4 chemokine receptor was upregulated by migratory progenitor cells just as they exited mouse neural tube explants, and SDF-1 acted as a chemoattractant for these cells.
Positive_regulation (upregulated) of CXCR4 chemokine receptor in neural tube associated with chemokine
1) Confidence 0.69 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.28
These data suggest that CXCL12-mediated migration of ESNPs requires the function of CXCR4.
Positive_regulation (requires) of CXCR4
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.18 Pain Relevance 0.14
Combined treatment additively increased VEGF and CXCR4 promoter activation.
Positive_regulation (activation) of CXCR4
3) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.47 Pain Relevance 0
additively increase prometastatic factors VEGF and CXCR4
Positive_regulation (increase) of CXCR4
4) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.85 Pain Relevance 0
-stimulated CXCR4 promoter activation.
Positive_regulation (activation) of CXCR4
5) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.86 Pain Relevance 0
VEGF and CXCR4 promoter activities were increased by treatment with TGF-?
Positive_regulation (increased) of CXCR4
6) Confidence 0.54 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.51 Pain Relevance 0
Our results indicate that I/R injury induces the homing of HSC in the injured kidney and that this preferred migration is not exclusively dependent on the SDF-1/CXCR4-axis.
Neg (not) Positive_regulation (dependent) of CXCR4 in kidney associated with injury
7) Confidence 0.41 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.39 Pain Relevance 0.04
We speculate that during the late stages of the viral life cycle when mostly structural proteins such as Gag are expressed, SDF-1 induced CXCR4 downregulation is attenuated resulting in the accumulation of densensitized CXCR4 within intracellular compartments.
Positive_regulation (accumulation) of CXCR4
8) Confidence 0.40 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.68 Pain Relevance 0.14
additively increase prometastatic factors VEGF and CXCR4
Positive_regulation (factors) of CXCR4
9) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.83 Pain Relevance 0
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (levels) of Cxcr4
10) Confidence 0.38 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Positive_regulation (elevated) of Cxcr4
11) Confidence 0.38 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
It is also of interest to examine if transient and constitutive CXCL12 stimulation of either CXCR4 or CXCR7 elicits distinct cellular outcomes.
Spec (examine) Positive_regulation (stimulation) of CXCR4
12) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.89 Pain Relevance 0.17
and Smads together resulted in a 10-fold increase in VEGF and CXCR4 promoter activities in the presence of TGF-?
Positive_regulation (increase) of CXCR4
13) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.84 Pain Relevance 0
VEGF, but not CXCR4, mRNA was additively increased by combined treatment with TGF-?
Positive_regulation (increased) of CXCR4
14) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.26 Pain Relevance 0
and 1% O2-stimulated VEGF and CXCR4 mRNAs were decreased in the DNRII and DNRII/shHIF clones compared to parental control (Figure 8E).
Positive_regulation (stimulated) of CXCR4
15) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.75 Pain Relevance 0
Thus, accumulation of intracellular HA-CXCR4 did not result in altered SDF-1 induced CXCR4 signaling in Gag expressing cells.


Positive_regulation (induced) of CXCR4
16) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0
The increase in intracellular CXCR4 induced by expression of HIV-1 Gag did not result in a change in SDF-1 mediated CXCR4 signaling, as judged by MAP kinase activation (Fig 2C).
Positive_regulation (increase) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
17) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.25 Pain Relevance 0
SDF-1 induced CXCR4 signaling could potentially be beneficial to viral replication since it results in the activation of transcription factors such as NF?
Positive_regulation (induced) of CXCR4
18) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.99 Pain Relevance 0
To test this hypothesis, the time course of pERK formation, a downstream readout of SDF-1 mediated CXCR4 signaling, was monitored.
Positive_regulation (mediated) of CXCR4
19) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.32 Pain Relevance 0
Thus, accumulation of intracellular HA-CXCR4 did not result in altered SDF-1 induced CXCR4 signaling in Gag expressing cells.


Neg (not) Positive_regulation (result) of CXCR4
20) Confidence 0.29 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.46 Pain Relevance 0

General Comments

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