INT126477

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Context Info
Confidence 0.66
First Reported 2003
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 22.02
Pain Relevance 3.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Sdf2l1) molecular_function (Sdf2l1) biological_process (Sdf2l1)
Anatomy Link Frequency
bone marrow 2
fibroblasts 2
stem cells 2
brain 1
monocyte 1
Sdf2l1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 119 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
ischemia 149 97.72 Very High Very High Very High
corticosteroid 2 96.80 Very High Very High Very High
Inflammation 231 96.24 Very High Very High Very High
imagery 268 96.12 Very High Very High Very High
cytokine 109 95.48 Very High Very High Very High
rheumatoid arthritis 52 92.04 High High
Chronic pancreatitis 5 87.84 High High
Inflammatory response 43 79.56 Quite High
Disease Link Frequency Relevance Heat
Cancer 121 100.00 Very High Very High Very High
Necrosis 65 100.00 Very High Very High Very High
Starvation 4 100.00 Very High Very High Very High
Injury 998 99.92 Very High Very High Very High
Wound Healing 455 99.60 Very High Very High Very High
Diabetes Mellitus 409 99.16 Very High Very High Very High
Asthma 41 98.92 Very High Very High Very High
Hypoxia 32 98.42 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 226 97.84 Very High Very High Very High
Cv Unclassified Under Development 151 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under physiological conditions, the bone marrow is the niche for HSC; the basal level of hypoxia in the bone marrow microenvironment may explain the constitutive and regional expression of SDF-1 in the bone marrow and the CXCR4-dependent stem and progenitor cell tropism to the bone marrow [22].
Gene_expression (expression) of SDF-1 in bone marrow associated with hypoxia
1) Confidence 0.66 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.15 Pain Relevance 0
This was also observed in the heart, where overexpression of SDF-1 without injury could not induce the homing of BMC [16].
Gene_expression (overexpression) of SDF-1 in heart associated with injury
2) Confidence 0.66 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.34 Pain Relevance 0
Recombinant first-generation E1-E3-deleted adenoviral (Ad) vectors for expression of SDF-1 and GFP were obtained using the Ad-Easy system as previously described [35].
Gene_expression (expression) of SDF-1
3) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0 Pain Relevance 0
This indicates that SDF-1 overexpression enhances survival/proliferation of administered cells at the lesion site at this time point, resulting in beneficial effects.
Gene_expression (overexpression) of SDF-1
4) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.27 Pain Relevance 0
Furthermore, we were interested in determining whether concomitant overexpression of SDF-1 may further promote wound healing and cell engraftment.
Gene_expression (overexpression) of SDF-1 associated with wound healing
5) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.91 Pain Relevance 0.09
Moreover, SDF-1 overexpression increased survival and growth of CXCR4-expressing mesenchymal stem cells both in vitro [27] and in vivo [28, 29].
Gene_expression (overexpression) of SDF-1 in stem cells
6) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 1.08 Pain Relevance 0.07
We then assessed whether overexpression of SDF-1, whose downmodulation plays a pivotal role in the pathophysiology of diabetic wounds, might result in a better therapeutic profile of the AT-SCs-mediated treatment.
Gene_expression (overexpression) of SDF-1 associated with diabetes mellitus and injury
7) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 1.13 Pain Relevance 0
Quantification of the BLI signal did not show any statistically significant difference between non-transduced cells and AT-SCs transduced with adenoviral vectors expressing GFP and SDF-1 (Figure 5) at the time of administration.
Gene_expression (expressing) of SDF-1
8) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.24 Pain Relevance 0.09
In particular, the percentage of wound closure 3 days after injury was 24 in control mice 41 and 58%, respectively, in animals receiving AT-SCs and AT-SCs expressing SDF-1.
Gene_expression (expressing) of SDF-1 associated with injury
9) Confidence 0.59 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 1.00 Pain Relevance 0.03
Migration of HSC is not prevented by blocking the SDF-1/CXCR4-axis
Gene_expression (/) of SDF-1
10) Confidence 0.57 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
Therefore, we hypothesized that endogenous SDF-1 levels in ischemic kidneys may be insufficient to properly attract HSC.
Gene_expression (levels) of SDF-1
11) Confidence 0.57 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0
On the other hand, exogenous administration at the lesion site of recombinant SDF-1 [24] or of a lentiviral vector expressing SDF-1 [25] reversed the impaired EPC homing in a murine model of diabetic wound healing.
Gene_expression (expressing) of SDF-1 associated with diabetes mellitus and wound healing
12) Confidence 0.52 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 1.02 Pain Relevance 0.08
On the other hand, exogenous administration at the lesion site of recombinant SDF-1 [24] or of a lentiviral vector expressing SDF-1 [25] reversed the impaired EPC homing in a murine model of diabetic wound healing.
Gene_expression (expressing) of SDF-1 associated with diabetes mellitus and wound healing
13) Confidence 0.51 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 1.03 Pain Relevance 0.08
Interestingly, we determined a statistically significant difference between BLI signals in animals receiving AT-SCs expressing SDF-1 relative to controls expressing GFP, 1 day after administration (Figure 8).
Gene_expression (expressing) of SDF-1
14) Confidence 0.51 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.28 Pain Relevance 0
The SDF-1?
Gene_expression (The) of SDF-1
15) Confidence 0.51 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.26 Pain Relevance 0
As shown in Figure 3, we found that transplantation of AT-SCs overexpressing SDF-1 promotes wound healing in diabetic animals.
Gene_expression (overexpressing) of SDF-1 associated with diabetes mellitus and wound healing
16) Confidence 0.51 Published 2011 Journal Stem Cells International Section Body Doc Link PMC3014681 Disease Relevance 0.29 Pain Relevance 0
The neutralizing capacity of anti-SDF-1 was determined by adding 17 ?
Gene_expression (capacity) of anti-SDF-1
17) Confidence 0.50 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0
In addition, our in vitro and in vivo HSC migration assays demonstrated a decreased migration towards high recSDF-1 levels and bone marrow, respectively, after neutralizing SDF-1 or CXCR4.
Gene_expression (levels) of recSDF-1 in bone marrow
18) Confidence 0.50 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.23 Pain Relevance 0.03
Stromal cell-derived factor-1 (SDF-1), the unique agonist for CXCR4, was expressed along the path taken by crest cells to the DRGs, suggesting that SDF-1/CXCR4 signaling is needed for their migration.
Gene_expression (expressed) of SDF-1 in crest associated with agonist
19) Confidence 0.49 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.21
In comparison with Snus-treated mice, TS-Elastase-IL-1beta mice had an earlier onset and a greater extent of phenotypic changes, which were associated with up-regulation of TNF-alpha and increased expression of IL-6, TGF-beta, and SDF-1.
Gene_expression (expression) of SDF-1
20) Confidence 0.47 Published 2010 Journal Lab. Invest. Section Abstract Doc Link 20065943 Disease Relevance 1.13 Pain Relevance 0.39

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