INT126478

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 78
Total Number 79
Disease Relevance 58.69
Pain Relevance 8.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) extracellular region (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
epithelial cells 5
hippocampus 3
platelet 2
stromal cells 2
adult brain 1
Cxcl12 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 1283 100.00 Very High Very High Very High
cytokine 209 100.00 Very High Very High Very High
metalloproteinase 28 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
Hippocampus 455 99.68 Very High Very High Very High
Inflammation 197 99.48 Very High Very High Very High
rheumatoid arthritis 13 95.80 Very High Very High Very High
fibrosis 32 80.12 Quite High
Multiple sclerosis 26 74.52 Quite High
imagery 228 73.44 Quite High
Disease Link Frequency Relevance Heat
Adhesions 1876 100.00 Very High Very High Very High
Leukemia 15 100.00 Very High Very High Very High
Convulsion 572 99.98 Very High Very High Very High
Colon Cancer 1325 99.86 Very High Very High Very High
Metastasis 1325 99.86 Very High Very High Very High
Carcinoma 1325 99.86 Very High Very High Very High
Cancer 981 99.76 Very High Very High Very High
Apoptosis 2492 99.68 Very High Very High Very High
Injury 126 99.68 Very High Very High Very High
Necrosis 102 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most pronounced increase in CXCL12 expression over basal levels was observed in the SGZ and hilus of the DG (arrows, Figure 4D).
Gene_expression (expression) of CXCL12 in hilus
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.60 Pain Relevance 0.11
These data demonstrate that seizures augment CXCL12 expression in the DG.


Gene_expression (expression) of CXCL12 associated with convulsion
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.62 Pain Relevance 0.10
Our studies suggest that at least part of the mechanism for guiding new cells to their final position in the granule cell layer is the expression of CXCL12, as ESNPs show a directional migration toward a source of this chemokine in vitro, and their migration is truncated in vivo after infusion with AMD3100, an inhibitor of CXCR4.
Gene_expression (expression) of CXCL12 in granule cell associated with chemokine
3) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.49 Pain Relevance 0.31
Our data corroborate earlier studies demonstrating that CXCL12 expression is increased following status epilepticus, but this increase may be transient without spontaneous recurrent seizures.
Gene_expression (expression) of CXCL12 associated with convulsion and status epilepticus
4) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 1.15 Pain Relevance 0.17
This hypothesis was supported by our finding that seizures upregulated CXCL12 expression in the hippocampus DG.
Gene_expression (expression) of CXCL12 in hippocampus associated with convulsion and hippocampus
5) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.50 Pain Relevance 0.39
Based on our in vitro migration data and the expression of CXCL12 in the DG, we hypothesized that CXCL12 guides the migration of ESNPs through the degenerating upper blade of the DG following transplantation.
Gene_expression (expression) of CXCL12 in upper
6) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.81 Pain Relevance 0.10
To determine whether ESNP dispersion is an active process guided by established chemoattractants, we investigated the role of CXCL12, a known chemokine expressed in the adult brain [38].
Gene_expression (expressed) of CXCL12 in adult brain associated with chemokine
7) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.17
We next asked whether seizures impacted the expression of CXCL12 in the hippocampus.
Gene_expression (expression) of CXCL12 in hippocampus associated with convulsion and hippocampus
8) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.50 Pain Relevance 0.13
Herein, we show re-establishment of CXCL12 expression is a novel inducer of Bim and Bak in colorectal carcinoma cells and sensitizes these cells to anoikis.
Gene_expression (expression) of CXCL12 associated with colon cancer
9) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.05 Pain Relevance 0.08
This decreased ability to adhere to tissue-culture-treated plastic dishes is shown for HT29 cells expressing CXCL12, which are increasingly incapable of maintaining a confluent monolayer compared to control (GFP) cells (Figure 1B).
Gene_expression (expressing) of CXCL12
10) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.14 Pain Relevance 0.08
Studies with knockdown cells revealed a key role for Bim in the survivability of metastatic tumor cells expressing CXCL12 in an in vivo orthotopic xenograft model.
Gene_expression (expressing) of CXCL12 associated with metastasis
11) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.41 Pain Relevance 0.10
Having demonstrated Bim expression was upregulated in non-adherent colorectal carcinoma cells expressing CXCL12, we next examined whether RNAi-mediated repression of Bim would reverse anoikis sensitivity in those cells.
Gene_expression (expressing) of CXCL12 associated with repression and colon cancer
12) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.56 Pain Relevance 0
Together, these data suggest constitutive CXCL12 expression is a novel extracellular regulator of anoikis by inducing Bim-mediated intrinsic apoptotic pathway and inhibiting metastasis.


Gene_expression (expression) of CXCL12 associated with apoptosis and metastasis
13) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.86 Pain Relevance 0.03
Recently, the homeostatic chemokine CXCL12 has been shown to be an essential mediator of cancer metastasis, with our laboratory demonstrating that silencing of endogenous CXCL12 expression establishes a pro-metastatic phenotype [20], [23], [24].
Gene_expression (expression) of CXCL12 associated with chemokine, cancer and metastasis
14) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.07 Pain Relevance 0.09
Together these data suggest that constitutive CXCL12 expression and production inhibits tumor formation by sensitizing colorectal carcinoma cells to anoikis via upregulation of the Bim regulator.


Gene_expression (expression) of CXCL12 associated with cancer and colon cancer
15) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.71 Pain Relevance 0.04
Moreover, HT29 cells expressing variable levels of CXCL12 (Hi and Med) demonstrated decreasing levels of total FAK protein (Figure 2C) coincident with diminished adherence (Figure 2D).
Gene_expression (expressing) of CXCL12
16) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.20 Pain Relevance 0.11
Autocrine CXCL12 expression sensitizes epithelial cells to anoikis
Gene_expression (expression) of CXCL12 in epithelial cells
17) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 0.32 Pain Relevance 0.07
HT29 (Figure 4B) and HCT116 (Figure 4C) cells producing varying levels of CXCL12 demonstrated a dose-dependent and preferential increase in caspase-9 activity relative to caspase-8 after four days of adherent cell culture, consistent with the activation of an intrinsic apoptotic mechanism.
Gene_expression (producing) of CXCL12 associated with apoptosis
18) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.08 Pain Relevance 0
In contrast to mammary carcinomas stimulated with exogenously added CXCL12 [25], we determined that re-establishment of CXCL12 expression characteristic of the normal epithelium increases anoikis sensitivity of colorectal carcinoma cells [13].
Gene_expression (expression) of CXCL12 in epithelium associated with colon cancer and carcinoma
19) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.23 Pain Relevance 0.08
In normal intestinal epithelium expression of CXCL12 parallels Bak along the crypt-villus axis with maximal protein observed at the crypt apex [24], [29].
Gene_expression (expression) of CXCL12 in villus
20) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943927 Disease Relevance 1.02 Pain Relevance 0.07

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