INT126479

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 10.75
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
osteoblast 1
DRGs 1
kidney 1
T cells 1
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 1 92.16 High High
Inflammation 4 89.60 High High
chemokine 24 81.16 Quite High
agonist 1 64.84 Quite High
antagonist 5 53.84 Quite High
qutenza 1 25.00 Low Low
imagery 27 5.00 Very Low Very Low Very Low
Kinase C 16 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
ketamine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 647 100.00 Very High Very High Very High
Hypoxia 387 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 300 100.00 Very High Very High Very High
Metastasis 530 99.92 Very High Very High Very High
Macroglobulinemia 14 99.44 Very High Very High Very High
Lymphatic System Cancer 36 99.04 Very High Very High Very High
Infection 40 98.64 Very High Very High Very High
Chronic Lymphoid Leukemia 7 96.00 Very High Very High Very High
Superinfection 16 95.52 Very High Very High Very High
Breast Cancer 170 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In WM, we observed a significant CXCR4 down-regulation in comparison to other NHL types (Figure 1).
Regulation (regulation) of CXCR4 associated with macroglobulinemia and lymphatic system cancer
1) Confidence 0.58 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 1.25 Pain Relevance 0
In sharp contrast to studies in other injured organs, our results indicate that migration of HSC to the ischemic damaged kidney is not solely dependent on the SDF-1/CXCR4 signalling axis.



Neg (not) Regulation (dependent) of CXCR4 in kidney
2) Confidence 0.37 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.12 Pain Relevance 0.03
regulates CXCR4 through other SBEs in the promoter that were not tested here.
Regulation (regulates) of CXCR4
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.87 Pain Relevance 0
Similarly, we observed no change in cell surface levels of CXCR4 in HIV-1 Gag-expressing cells (Fig. 3F).
Neg (no) Regulation (change) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.26 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 1.04 Pain Relevance 0
Therefore, studying the effects of HIV-1 Gag expression on CXCR4 downregulation kinetics in these cells should provide insight into the physiologic processes occurring during HIV-1 infection.
Regulation (effects) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection and infection
5) Confidence 0.26 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.94 Pain Relevance 0
and hypoxia regulate VEGF promoter activity, while only hypoxia regulates CXCR4 promoter activity.
Regulation (regulate) of CXCR4 associated with hypoxia
6) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.87 Pain Relevance 0
signaling pathways regulate tumor-secreted factors such as CXCR4 which promotes tumor cell homing to the bone [50], and VEGF which stimulates tumor angiogenesis and increases both osteoclast [65], [69] and osteoblast activity [61].
Regulation (regulate) of CXCR4 in osteoblast associated with cancer and osteoporosis
7) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.36 Pain Relevance 0
promotes bone metastases by regulating factors such as CXCR4, which promotes tumor cell homing to bone [50] and VEGF, which promotes angiogenesis.
Regulation (regulating) of CXCR4 associated with cancer and metastasis
8) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.53 Pain Relevance 0.03
and hypoxia regulate VEGF promoter activity, while only hypoxia regulates CXCR4 promoter activity.
Regulation (regulates) of CXCR4 associated with hypoxia
9) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.86 Pain Relevance 0
Our findings indicate an important role for SDF-1/CXCR4 signaling in directing the migration of sensory neuron progenitors to the DRG and potentially in other aspects of development once the DRGs have coalesced.
Regulation (role) of CXCR4 in DRGs
10) Confidence 0.20 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.23
Thus, an important question is whether levels of CXCR4 are altered in the context of an HIV-1 infected cell.
Spec (whether) Regulation (altered) of CXCR4 associated with acquired immune deficiency syndrome or hiv infection
11) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.72 Pain Relevance 0
In order to examine the effects of Gag expression on endogenous CXCR4, we monitored the kinetics of SDF-1 induced downregulation of CXCR4 in Jurkat T cells.
Spec (examine) Regulation (effects) of CXCR4 in T cells
12) Confidence 0.16 Published 2008 Journal Virol J Section Body Doc Link PMC2262066 Disease Relevance 0.85 Pain Relevance 0
Previous studies have shown the importance of the SDF-1/CXCR4-axis in the migration of BMC.
Regulation (importance) of CXCR4
13) Confidence 0.10 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.34 Pain Relevance 0.04

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