INT126481

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2005
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 69
Total Number 73
Disease Relevance 34.99
Pain Relevance 6.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cxcr4) signal transduction (Cxcr4) cytoplasmic membrane-bounded vesicle (Cxcr4)
plasma membrane (Cxcr4) signal transducer activity (Cxcr4)
Anatomy Link Frequency
T cells 4
B-cells 3
blood 2
CD86 2
lungs 2
Cxcr4 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 361 100.00 Very High Very High Very High
agonist 23 99.90 Very High Very High Very High
cytokine 93 99.34 Very High Very High Very High
nociceptor 4 97.28 Very High Very High Very High
opiate 1 96.32 Very High Very High Very High
imagery 132 96.20 Very High Very High Very High
Inflammation 142 93.84 High High
antagonist 21 89.92 High High
Hippocampus 105 89.88 High High
Kinase C 72 83.92 Quite High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 1383 100.00 Very High Very High Very High
Adhesions 245 100.00 Very High Very High Very High
Carcinoma 151 99.96 Very High Very High Very High
Sprains And Strains 9 99.96 Very High Very High Very High
Breast Cancer 298 99.74 Very High Very High Very High
Colon Cancer 150 99.74 Very High Very High Very High
Chronic Lymphoid Leukemia 49 99.72 Very High Very High Very High
Hypoxia 628 99.64 Very High Very High Very High
Lymphatic System Cancer 253 99.44 Very High Very High Very High
Macroglobulinemia 98 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stromal cell-derived factor-1 (SDF-1), the unique agonist for CXCR4, was expressed along the path taken by crest cells to the DRGs, suggesting that SDF-1/CXCR4 signaling is needed for their migration.
Gene_expression (expressed) of CXCR4 in crest associated with agonist
1) Confidence 0.77 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.21
In mouse embryos, we observed expression of the chemokine (CXC motif) receptor 4 (CXCR4) by neural crest cells migrating from the dorsal neural tube and in the dorsal root ganglia (DRGs).
Gene_expression (expression) of CXCR4 in embryos associated with chemokine
2) Confidence 0.77 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.20
Furthermore, DRGs contained a population of progenitor cells that expressed CXCR4 receptors in vitro and differentiated into neurons with a similar phenotype.
Gene_expression (expressed) of CXCR4 in neurons
3) Confidence 0.77 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.27
In fact, CXCR4 expression on B lymphocytes was found to be down-regulated when compared to other NHL types (p < 0.001).
Gene_expression (expression) of CXCR4 in B lymphocytes associated with lymphatic system cancer
4) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.51 Pain Relevance 0.06
CXCR4 expression in different NHL subtypes
Gene_expression (expression) of CXCR4 associated with lymphatic system cancer
5) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 1.12 Pain Relevance 0
For CXCR4 detection, 10 ?
Gene_expression (detection) of CXCR4
6) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.38 Pain Relevance 0
We also evaluated CXCR4 expression on B-cells in 54 paired BM-aspirates and PB (10 WM, 14 DLBC, 18 FL and 12 CLL).
Gene_expression (expression) of CXCR4 in B-cells associated with chronic lymphoid leukemia
7) Confidence 0.73 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.39 Pain Relevance 0
Most CXCR4-expressing progenitors differentiated to form sensory neurons with the properties of polymodal nociceptors.
Gene_expression (expressing) of CXCR4-expressing in nociceptors associated with nociceptor
8) Confidence 0.67 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843601 Disease Relevance 0 Pain Relevance 0.28
Those GPCRs that were highly expressed by BMM, but not TEPM, included Ebi2, Calcrl, Ccr2 and 5, Cxcr3, Cx3cr1 and Gpr84, whilst TEPM expressed much higher levels of Cxcr4, Gpr35, P2ry1, Ccr1, Cd97, Ccrl2 and Gprc5b (Table 2).
Gene_expression (expressed) of Cxcr4
9) Confidence 0.63 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.19 Pain Relevance 0.09
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of Cxcr4
10) Confidence 0.63 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.18
For CXCR4 detection, 10 ?
Gene_expression (detection) of CXCR4
11) Confidence 0.63 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 0.38 Pain Relevance 0
In culture, ESNPs, as well as ESC-derived immature neurons, expressed CXCR4, a receptor for CXCL12 required for CXCL12-mediated chemotaxis (Figure 3A, B).
Gene_expression (expressed) of CXCR4 in neurons
12) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.17
To further investigate CXCL12-mediated guidance mechanisms, we next examined expression of CXCR4 and CXCR7, the two receptors that bind CXCL12 [39].
Spec (examined) Gene_expression (expression) of CXCR4
13) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0 Pain Relevance 0.11
CXCR4 is more highly expressed in human breast cancer metastases to bone than to the lungs or brain [52].
Gene_expression (expressed) of CXCR4 in brain associated with breast cancer and metastasis
14) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 1.53 Pain Relevance 0.04
signaling pathways regulates VEGF and CXCR4 mRNA expression and promoter activation.


Gene_expression (expression) of CXCR4 mRNA
15) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0.49 Pain Relevance 0
The expression of CXCR4, a receptor involved in B-cell trafficking and homing, was found to be down regulated in WM compared to other NHL types, thus suggesting a possible role of CXCR4 in WM cell homing in the BM.
Gene_expression (expression) of CXCR4 in B-cell associated with lymphatic system cancer
16) Confidence 0.57 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2995803 Disease Relevance 0.64 Pain Relevance 0
Our current results suggest that CXCR4 expression is variable among different NHL subtypes, and lead to speculate a CXCR4 involvement in NHL blood spreading, possibly explaining the discordant results of BM and PB analyses in WM versus other NHL types.
Gene_expression (expression) of CXCR4 in blood associated with macroglobulinemia and lymphatic system cancer
17) Confidence 0.57 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2995803 Disease Relevance 1.57 Pain Relevance 0
TEPM expressed elevated levels of mRNA for Cxcr4, Ccr1, Ccrl2, whilst BMM expressed higher levels of Ccr2, Cx3cr1 and Cxcr3.
Gene_expression (expressed) of Cxcr4
18) Confidence 0.55 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.31 Pain Relevance 0.16
Migration of HSC is not prevented by blocking the SDF-1/CXCR4-axis
Gene_expression (/) of CXCR4
19) Confidence 0.55 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0.07 Pain Relevance 0
The neutralizing capacity of anti-CXCR4 was determined by adding HSC pre-incubated with CXCR4 (20 ?
Spec (determined) Gene_expression (determined) of CXCR4
20) Confidence 0.55 Published 2009 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2698094 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox