INT126484

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 4.08
Pain Relevance 6.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
neurons 4
sensory neurons 2
nociceptors 2
urinary bladder 1
nerve 1
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 83 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
nociceptor 13 100.00 Very High Very High Very High
Neuropeptide 4 99.90 Very High Very High Very High
TRP channel 16 99.82 Very High Very High Very High
Eae 15 99.48 Very High Very High Very High
antagonist 36 98.80 Very High Very High Very High
Mechanotransduction 1 98.72 Very High Very High Very High
substantia gelatinosa 4 98.48 Very High Very High Very High
Glutamate receptor 3 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 27 100.00 Very High Very High Very High
Injury 20 99.48 Very High Very High Very High
Neurogenic Inflammation 5 98.52 Very High Very High Very High
Urological Neuroanatomy 32 96.32 Very High Very High Very High
Stress 2 96.04 Very High Very High Very High
Pain 69 95.60 Very High Very High Very High
INFLAMMATION 43 93.20 High High
Hyperalgesia 25 91.88 High High
Asthma 1 91.52 High High
Nervous System Injury 10 87.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known.
Localization (secretion) of TRPA1 associated with agonist
1) Confidence 0.80 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 18838811 Disease Relevance 0 Pain Relevance 0.28
These results indicate that TRPA1 appears to be localized not only at presynaptic terminals on SG neurons to enhance glutamate release, but also in terminals of primary afferents innervating onto spinal inhibitory interneurons, which make synapses with SG neurons.
Localization (localized) of TRPA1 in neurons associated with substantia gelatinosa and glutamate
2) Confidence 0.80 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17442829 Disease Relevance 0 Pain Relevance 0.82
Icilin, the peripheral cold channel agonist, activates TRPM8 and TRPA1, localized on dorsal root ganglia and trigeminal neurons in rats.
Localization (localized) of TRPA1 in neurons associated with agonist
3) Confidence 0.79 Published 2006 Journal Amino Acids Section Abstract Doc Link 16622598 Disease Relevance 0 Pain Relevance 0.29
TRPV1 and TRPA1 RNA were significantly decreased in DRG from RTX-treated rats, indicating functional colocalization of TRPA1 and TRPV1 in sensory nociceptors.
Localization (colocalization) of TRPA1 in nociceptors associated with nociceptor
4) Confidence 0.77 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17517374 Disease Relevance 0.53 Pain Relevance 0.46
TRPA1 and calcitonin-gene related peptide were co-localized in subepithelial sensory nerves of the bladder.
Localization (co-localized) of TRPA1 in sensory nerves
5) Confidence 0.75 Published 2007 Journal Urology Section Body Doc Link 17991581 Disease Relevance 0.07 Pain Relevance 0
This correlates well with the fact that all types of MA currents can be recorded from TRPA1-negative DRG neurons.
Neg (negative) Localization (recorded) of TRPA1 in neurons
6) Confidence 0.75 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 19348834 Disease Relevance 0 Pain Relevance 0.16
As shown here and previously, TRPA1 is expressed by hair cells as well as by most nociceptors (small neurons of dorsal root, trigeminal, and nodose ganglia) and localizes to their sensory terminals (mechanosensory stereocilia and peripheral free nerves, respectively).
Localization (localizes) of TRPA1 in hair cells associated with nociceptor
7) Confidence 0.74 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15843607 Disease Relevance 0.34 Pain Relevance 0.57
Taken together, these results indicate that TRPA1 agonists contract rat urinary bladder through sensory fibre stimulation, depending on extracellular Ca(2+) influx and release of tachykinins and cyclooxygenase metabolites, probably prostaglandin E(2).
Localization (release) of TRPA1 in urinary bladder associated with agonist
8) Confidence 0.74 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16725114 Disease Relevance 0 Pain Relevance 0.54
TRPV1 and TRPA1 RNA were significantly decreased in DRG from RTX-treated rats, indicating functional colocalization of TRPA1 and TRPV1 in sensory nociceptors.
Localization (colocalization) of TRPA1 in nociceptors associated with nociceptor
9) Confidence 0.72 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17517374 Disease Relevance 0.54 Pain Relevance 0.47
TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.
Localization (secretion) of TRPA1 associated with qutenza and agonist
10) Confidence 0.70 Published 2008 Journal Biosci. Biotechnol. Biochem. Section Title Doc Link 18838811 Disease Relevance 0 Pain Relevance 0.51
A recent report has also demonstrated localization of TRPA1 to a subclass of large diameter primary afferent sensory neurons and epidermal kerantinocytes [8].
Localization (localization) of TRPA1 in sensory neurons
11) Confidence 0.70 Published 2010 Journal Mol Pain Section Body Doc Link PMC2841076 Disease Relevance 0.31 Pain Relevance 0.20
In addition to these morphological changes, increased cAMP levels in oxaliplatin-treated neurons (Figure 4) correlated with functional effects of TRPV1 and TRPA1 sensitization, not observed for TRPM8, after acute and chronic treatment with oxaliplatin (Figure 6).
Localization (sensitization) of TRPA1 in neurons
12) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC3003244 Disease Relevance 0.14 Pain Relevance 0.14
Proinflammatory neuropeptides are released from nociceptive nerve terminals after TRPV1/TRPA1 stimulation, thereby causing airway neurogenic inflammation.
Localization (released) of TRPA1 in nerve associated with nociception, inflammation, neuropeptide and neurogenic inflammation
13) Confidence 0.40 Published 2010 Journal Curr Opin Investig Drugs Section Abstract Doc Link 20419599 Disease Relevance 0.81 Pain Relevance 0.40
Thus, TRPV1 receptor (and hopefully other TRP channels such as TRPA1 and TRPM8 which often co-localize with TRPV1 on peripheral nerve terminals) may offer a suitable target for enhancing the activity of the endogenous antinociceptive descending pathway and producing analgesia.
Localization (localize) of TRPA1 in peripheral nerve associated with trp channel, antinociceptive and analgesia
14) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.71 Pain Relevance 1.36
The temperature-sensitive transient receptor potential (TRP) channels, is also called thermo TRP, including TRPV1, TRPV2, TRPV3, TRPV4, TRPM8 and TRPA1, which are expressed in sensory neurons and non-neuronal cells (e.g.keratinocyte, mast cell) of the skin.
Localization (called) of TRPA1 in sensory neurons
15) Confidence 0.15 Published 2009 Journal Zhejiang Da Xue Xue Bao Yi Xue Ban Section Abstract Doc Link 19693981 Disease Relevance 0.62 Pain Relevance 0.46

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox