INT126504

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 4.30
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
brain 3
nerve 1
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 24 100.00 Very High Very High Very High
Inflammation 7 99.84 Very High Very High Very High
Nerve growth factor 135 99.38 Very High Very High Very High
long-term potentiation 7 99.28 Very High Very High Very High
Central nervous system 26 92.48 High High
hypoalgesia 1 83.36 Quite High
Pain 35 81.44 Quite High
algogenic 1 78.08 Quite High
c fibre 4 74.92 Quite High
tetrodotoxin 1 70.96 Quite High
Disease Link Frequency Relevance Heat
Infection 144 99.88 Very High Very High Very High
INFLAMMATION 7 99.84 Very High Very High Very High
Injury 29 99.04 Very High Very High Very High
Pain 34 96.64 Very High Very High Very High
Apoptosis 11 95.36 Very High Very High Very High
Asthma 2 92.80 High High
Viral Infection 39 86.20 High High
Neuroma 25 84.60 Quite High
Cytomegalovirus Infection 168 84.04 Quite High
Hypoalagesia 1 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluates the effects of NT-3 and BDNF on nerve mediated airway contractions in vitro.
Regulation (effects) of NT-3 in nerve
1) Confidence 0.39 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.18 Pain Relevance 0.11
Down-regulation of the gene encoding of the neurotrophin NT3 was also associated with viral brain infection.
Regulation (regulation) of neurotrophin NT3 in brain associated with neurotrophin 3 and infection
2) Confidence 0.36 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 1.13 Pain Relevance 0.19
OBJECTIVE: The purpose of the present study was to examine the effects of moderate-intensity aerobic exercise on pain-like behavior and NT-3 in an animal model of widespread pain.
Spec (examine) Regulation (effects) of NT-3
3) Confidence 0.24 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.10 Pain Relevance 0
This neonatal brain infection was also associated with altered expression of Oct4, a multipotency marker; as well as down regulation of the neurotrophins BDNF and NT3, which are essential to regulate the birth and differentiation of neurons during normal brain development.
Regulation (regulation) of NT3 in brain associated with infection
4) Confidence 0.22 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3020957 Disease Relevance 1.52 Pain Relevance 0
Viral brain infection down-regulates BDNF and NT3 levels
Regulation (regulates) of NT3 in brain associated with infection
5) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.34 Pain Relevance 0.17
In the adult, neurotrophins appear to be expressed in most tissues at very low levels, whereas the levels of NGF (and in some tissues BDNF and NT-3) are dramatically up-regulated by inflammation and/or injury [14,16].
Regulation (regulated) of NT-3 associated with inflammation, nerve growth factor and injury
6) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004846 Disease Relevance 0.64 Pain Relevance 0.93
In this review we discuss the evidence supporting the neurotrophin system's role in preventing neurodegeneration and survey some of the pharmacological strategies being pursued to develop effective therapeutics targeting neurotrophin function.



Regulation (targeting) of neurotrophin
7) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2604901 Disease Relevance 0.08 Pain Relevance 0
These are small molecules that can alter neurotrophin function in a manner independent of ligand binding to receptor.
Regulation (alter) of neurotrophin
8) Confidence 0.05 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.32 Pain Relevance 0.13

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