INT126505

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 9.17
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
neural 4
muscle 1
brain 1
geniculate ganglion 1
central nervous system 1
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 465 100.00 Very High Very High Very High
bDMF 167 100.00 Very High Very High Very High
Hippocampus 51 99.90 Very High Very High Very High
Thalamus 22 99.52 Very High Very High Very High
Central nervous system 13 99.50 Very High Very High Very High
dexamethasone 8 99.40 Very High Very High Very High
Pyramidal cell 26 98.64 Very High Very High Very High
Serotonin 42 97.84 Very High Very High Very High
antidepressant 98 97.08 Very High Very High Very High
agonist 42 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Asthma 16 99.66 Very High Very High Very High
Injury 75 99.56 Very High Very High Very High
Stress 22 99.36 Very High Very High Very High
Ganglion Cysts 143 98.34 Very High Very High Very High
Brain Injury 43 98.32 Very High Very High Very High
Lifespan 2 97.26 Very High Very High Very High
INFLAMMATION 56 94.52 High High
Neuropathic Pain 8 94.16 High High
Cognitive Disorder 50 92.44 High High
Disease 278 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the increase in NT-3 protein was significant in the gastrocnemius muscle but not in the soleus muscle, suggesting that exercise can preferentially target NT-3 synthesis in specific muscle types.
Positive_regulation (increase) of NT-3 in muscle
1) Confidence 0.70 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.06 Pain Relevance 0
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (elevated) of neurotrophin-3 in neural associated with asthma
2) Confidence 0.70 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (elevated) of NT-3 in neural associated with asthma
3) Confidence 0.70 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
The increase in NT-3 was more pronounced at the protein level compared with mRNA expression.
Positive_regulation (increase) of NT-3
4) Confidence 0.61 Published 2010 Journal Phys Ther Section Body Doc Link 20338916 Disease Relevance 0.06 Pain Relevance 0
Considering the elevated levels of NT-3 found in asthmatic airways, the findings imply a protective role of NT-3 in AHR.
Positive_regulation (elevated) of NT-3 associated with asthma
5) Confidence 0.61 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.22 Pain Relevance 0.12
In vitro, geniculate axon outgrowth requires the addition of a neurotrophin to the culture media.
Positive_regulation (requires) of neurotrophin
6) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.14 Pain Relevance 0.14
These findings indicate that while a neurotrophin is required for geniculate axon outgrowth, neurotrophins are capable functioning redundantly in vivo to support the growth of axons.
Positive_regulation (required) of neurotrophin
7) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.15 Pain Relevance 0.14
Neurotrophins are also required for axon outgrowth from the geniculate ganglion; however, different neurotrophic factors function redundantly such that no single neurotrophin is required.
Positive_regulation (required) of neurotrophin in geniculate ganglion associated with ganglion cysts
8) Confidence 0.48 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1995452 Disease Relevance 0.24 Pain Relevance 0.04
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (levels) of neurotrophin-3 in neural associated with asthma
9) Confidence 0.47 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (levels) of NT-3 in neural associated with asthma
10) Confidence 0.47 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
The timing of neurotrophin/Trk signalling requirements and the cell types affected by the neurotrophin deficiencies have been well studied [26].
Positive_regulation (requirements) of neurotrophin
11) Confidence 0.39 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.46 Pain Relevance 0.03
DRG explants isolated from E13.5 were cultured for 48 hours in the presence of either the neurotrophic factor NT3 or NGF.
Positive_regulation (presence) of neurotrophic factor NT3
12) Confidence 0.34 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.25 Pain Relevance 0
One candidate for such a cue is the neurotrophin NT-3, which is specifically required for dLGN axons to invade the cortical plate in V1 [33].
Positive_regulation (required) of NT-3
13) Confidence 0.19 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2672616 Disease Relevance 0 Pain Relevance 0.03
Some agents modulate the expression of the neurotrophins themselves, while others act by enhancing neurotrophin action.
Positive_regulation (enhancing) of neurotrophin
14) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.46 Pain Relevance 0.13
As for the agents acting by enhancing neurotrophin action, xaliproden is a combined NGF potentiator and serotonin 5-HT1A receptor agonist that also reduces chemotherapy-induced peripheral sensory neuropathy but has yet to show efficacy in cognitive decline in AD.
Positive_regulation (enhancing) of neurotrophin associated with cognitive disorder, nerve growth factor, neuropathic pain, agonist, disease and serotonin
15) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.68 Pain Relevance 0.49
In this way, neurotrophin action would only be enhanced where endogenous neurotrophins are found.
Positive_regulation (enhanced) of neurotrophin
16) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.31 Pain Relevance 0.27
More specific MLK inhibitors that lack the TrkA inhibitory activity can still enhance neurotrophin action.
Positive_regulation (enhance) of neurotrophin
17) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.36 Pain Relevance 0.43
Therefore, we hypothesized that similar compounds could potentially activate signaling in the central nervous system and be used as oral NGF activators for neurotrophin therapy.
Positive_regulation (activators) of neurotrophin in central nervous system associated with nerve growth factor and central nervous system
18) Confidence 0.09 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.51 Pain Relevance 0.19
In the former class, a purine-hypoxanthine derivative, leteprinim (Neotrofin), has been shown to elevate neurotrophin levels (including NGF) in animals, and caused increases in acetylcholinesterase labeling in lesioned rats [106].
Positive_regulation (elevate) of neurotrophin associated with nerve growth factor
19) Confidence 0.08 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.50 Pain Relevance 0.19
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Positive_regulation (increases) of neurotrophin in hippocampus associated with stress, pain, lifespan and hippocampus
20) Confidence 0.08 Published 2008 Journal Exp. Gerontol. Section Title Doc Link 18065182 Disease Relevance 0.81 Pain Relevance 0.53

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