INT126506

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.32
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
neurons 2
neural 2
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 27 94.52 High High
tetrodotoxin 1 59.36 Quite High
cytokine 16 7.44 Low Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
rheumatoid arthritis 4 5.00 Very Low Very Low Very Low
trk B 2 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 6 99.66 Very High Very High Very High
INFLAMMATION 35 94.52 High High
Hematological Disease 24 67.28 Quite High
Apoptosis 10 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Asthmatic airways contain elevated levels of neurotrophin-3 (NT-3) and brain-derived neurotrophic factor (BDNF) albeit, their effect on neural activity is unclear.
Positive_regulation (levels) of Positive_regulation (elevated) of neurotrophin-3 in neural associated with asthma
1) Confidence 0.47 Published 2005 Journal Respir Physiol Neurobiol Section Abstract Doc Link 15848126 Disease Relevance 0.19 Pain Relevance 0.11
In neurons, it has been established that neurotrophin stimulation activates signaling through NF-?
Positive_regulation (activates) of Positive_regulation (stimulation) of neurotrophin in neurons
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0 Pain Relevance 0
To investigate the role of the Akt pathway in neurotrophin induction of IL-6, BMSC were pre-treated as described above with Akt VIII, a specific Akt inhibitor, for 2 hrs prior to stimulation with NGF or BDNF.
Spec (investigate) Positive_regulation (pathway) of Positive_regulation (induction) of neurotrophin
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.13 Pain Relevance 0

General Comments

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