INT126512

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.20
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
cytoplasm (Col1a1)
Anatomy Link Frequency
ligament 4
stellate cells 2
tendon 1
skeletal muscle 1
Col1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 25 81.44 Quite High
fibrosis 32 72.96 Quite High
Inflammation 10 70.00 Quite High
antagonist 4 50.00 Quite Low
Chronic pancreatitis 3 50.00 Quite Low
imagery 1 22.16 Low Low
Osteoarthritis 12 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Muscle Disease 87 93.92 High High
Proteinuria 1 83.04 Quite High
Renal Disease 8 80.36 Quite High
Atrophy 2 75.12 Quite High
Diabetes Mellitus 6 74.36 Quite High
Fibrosis 34 72.96 Quite High
INFLAMMATION 12 70.00 Quite High
Chronic Renal Failure 2 66.72 Quite High
Disease 14 60.12 Quite High
Ureteral Obstruction 16 60.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of Spec (determined) Gene_expression (expression) of Col1a1 in ligament
1) Confidence 0.39 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
DA-9601 decreased the expressions of alpha-SMA and type I collagen in cultured pancreatic stellate cells.
Negative_regulation (decreased) of Gene_expression (expressions) of type I collagen in stellate cells
2) Confidence 0.24 Published 2005 Journal Pancreatology Section Body Doc Link 15849487 Disease Relevance 0.16 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of in tendon Spec (determined) Gene_expression (expression) of Col1a1 in ligament
3) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Negative_regulation (levels) of in skeletal muscle Spec (determined) Gene_expression (expression) of Col1a1 in ligament
4) Confidence 0.13 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
This was further confirmed in 6-month-old male mice in which collagen type I degradation products had decreased in both K?
Negative_regulation (decreased) of Gene_expression (products) of collagen type I
5) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
activation reduced type I collagen synthesis and secretion.
Negative_regulation (reduced) of Gene_expression (synthesis) of type I collagen
6) Confidence 0.06 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 1.23 Pain Relevance 0.27

General Comments

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