INT126513

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 23
Total Number 26
Disease Relevance 10.92
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
cytoplasm (Col1a1)
Anatomy Link Frequency
skeletal muscle 3
extracellular matrix 3
fibroblasts 2
stroma 1
mesenchyme 1
Col1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 30 100.00 Very High Very High Very High
cytokine 43 99.28 Very High Very High Very High
Inflammation 193 94.96 High High
Bile 3 94.68 High High
fibrosis 149 91.28 High High
Chronic pancreatitis 8 91.00 High High
Arthritis 43 88.20 High High
agonist 25 81.12 Quite High
Inflammatory response 20 81.04 Quite High
imagery 8 80.80 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 58 99.84 Very High Very High Very High
Disease 73 97.84 Very High Very High Very High
Immunization 5 96.92 Very High Very High Very High
Stress 144 96.88 Very High Very High Very High
Calcification 7 95.36 Very High Very High Very High
INFLAMMATION 200 94.96 High High
Adhesions 12 94.88 High High
Muscle Disease 145 93.92 High High
Hypercalcemia 56 92.24 High High
Osteoporosis 68 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the Thy1high subset is distinguished by a nearly exclusive expression of Col1a1, Slit3, and Lox, and as expected from FACS analysis, by Sca1 (Figure 8C).
Gene_expression (expression) of Col1a1
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col1a1 in ligament
2) Confidence 0.71 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression of several collagen genes (e.g., Col1a1 and Col3a1) exhibited age-associated declines.
Gene_expression (expression) of Col1a1
3) Confidence 0.67 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2931699 Disease Relevance 0.86 Pain Relevance 0.12
The most abundant gene transcript was Col1a1, which was unsurprising since type I collagen is the most abundant protein of tendon and ligament and an abundant component of the skeletal muscle ECM.
Gene_expression (unsurprising) of Col1a1 in skeletal muscle
4) Confidence 0.62 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.07 Pain Relevance 0
Genotyping of 15 SNPs in the VDR, CTR, IL-6, COL1A1, COL1A2, and LRP5 genes
Gene_expression (genes) of COL1A1
5) Confidence 0.61 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.21 Pain Relevance 0
When we compared microarray data for two clones, G-2C9 and G-2C11, with parental G-2 cells as a reference, we observed that the list of genes weaker expressed in the subclones (FC>3; list of genes is in Table S1) includes the Thy1 gene and genes coding for the transcription factor Twist2, which promotes metastatic spreading [38], the secreted protein Slit3, which is expressed in mammary gland [39] and fetal lung mesenchyme [40], the lysyl oxidase (Lox) involved in the crosslinking of collagens and the formation of a premetastatic niche [41], and several collagen-coding genes (Col1a1, Col1a2, Col5a1, Col5a2, Col8a1 and Col12a1).
Gene_expression (expressed) of Col1a1 in mesenchyme
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.06 Pain Relevance 0
The most abundant gene transcript was Col1a1, which was unsurprising since type I collagen is the most abundant protein of tendon and ligament and an abundant component of the skeletal muscle ECM.
Gene_expression (component) of I collagen in skeletal muscle
7) Confidence 0.54 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.07 Pain Relevance 0
We confirmed significantly lower transcript levels of Col1a1, Col1a2, Col3a1 and Col4a1 in aged stroma by qRT-PCR (Figure 5A).
Gene_expression (levels) of Col1a1 in stroma
8) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931699 Disease Relevance 0.43 Pain Relevance 0.08
DA-9601 decreased the expressions of alpha-SMA and type I collagen in cultured pancreatic stellate cells.
Gene_expression (expressions) of type I collagen in stellate cells
9) Confidence 0.43 Published 2005 Journal Pancreatology Section Body Doc Link 15849487 Disease Relevance 0.16 Pain Relevance 0
Histochemical analysis revealed that collagen type II was more expressed in hyaline tissue (very intense), whereas collagen type I was predominant in fibrocartilage (very intense) (Figures 1c,d, 2c,d and 3c,d).
Gene_expression (predominant) of collagen type I in fibrocartilage
10) Confidence 0.28 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656234 Disease Relevance 0.08 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col1a1 in tendon
11) Confidence 0.24 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col1a1 in skeletal muscle
12) Confidence 0.24 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
COL1A1 and COL3A1 are significantly down expressed as compared to the control when exposed to the osteoplant, probably because these genes are activated in the late stage of differentiation and are related to extracellular matrix synthesis.
Gene_expression (expressed) of COL1A1 in extracellular matrix
13) Confidence 0.18 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.32 Pain Relevance 0
This was further confirmed in 6-month-old male mice in which collagen type I degradation products had decreased in both K?
Gene_expression (products) of collagen type I
14) Confidence 0.16 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
To investigate the osteogenic differentiation of PB-hMSCs, the quantitative expression of the mRNA of specific genes, such as, transcriptional factors (RUNX2 and SP7), bone-related genes (SPP1, COL1A1, COL3A1, BGLAP, ALPL, and FOSL1), and mesenchymal stem cell markers (ENG) were examined, by means of real time Reverse Transcription-Polymerase Chain Reaction (RT-PCR).


Gene_expression (expression) of COL1A1 in stem cell
15) Confidence 0.16 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.09 Pain Relevance 0
Toom et al. [18] found that the expression of BMP-2 and TGF are higher in ectopic bones and Chauvean et al. [19] reported strong over expression of osteocalcin mRNA, an event associated with upregulation of osteonectin and collagen type I synthesis.
Gene_expression (synthesis) of collagen type I
16) Confidence 0.15 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956094 Disease Relevance 0.27 Pain Relevance 0.06
SPARC siRNA significantly reduced gene and protein expression of collagen type 1 in fibroblasts obtained from the TBR1CA; Cre-ER mouse that was induced for constitutively active TGF-?
Gene_expression (expression) of collagen type 1 in fibroblasts
17) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2888211 Disease Relevance 0.66 Pain Relevance 0.12
Fibroblasts synthesize an extracellular matrix comprising collagen type I and type III, fibronectin, and proteoglycans [17].
Gene_expression (synthesize) of collagen type I in extracellular matrix
18) Confidence 0.14 Published 2008 Journal Crit Care Section Body Doc Link PMC2575592 Disease Relevance 1.18 Pain Relevance 0.29
1, and collagen type I expression using real-time RT–PCR.
Gene_expression (expression) of collagen type I
19) Confidence 0.12 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.14
Serum levels of RatLaps (type I collagen cross-links) were greatly enhanced in the CII-immunized mice, in comparison with controls (Fig. 4b).
Gene_expression (cross) of type I collagen in CII
20) Confidence 0.11 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175035 Disease Relevance 1.32 Pain Relevance 0.39

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