INT126514

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 16
Total Number 24
Disease Relevance 16.21
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CCR7) intracellular (CCR7) signal transducer activity (CCR7)
Anatomy Link Frequency
CD86 6
lymph nodes 4
blood 3
T cells 2
PDL-1 1
CCR7 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 268 100.00 Very High Very High Very High
Inflammation 488 97.32 Very High Very High Very High
agonist 38 97.08 Very High Very High Very High
cytokine 96 95.52 Very High Very High Very High
Osteoarthritis 19 89.12 High High
rheumatoid arthritis 79 86.88 High High
Chronic pancreatitis 114 74.88 Quite High
Inflammatory response 18 71.56 Quite High
Inflammatory mediators 12 59.48 Quite High
psoriasis 4 50.72 Quite High
Disease Link Frequency Relevance Heat
Disease 235 99.84 Very High Very High Very High
Infection 648 99.74 Very High Very High Very High
Adenocarcinoma 990 99.20 Very High Very High Very High
Disease Progression 94 97.64 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 291 97.44 Very High Very High Very High
Apoptosis 179 97.40 Very High Very High Very High
INFLAMMATION 519 97.32 Very High Very High Very High
Breast Cancer 46 95.72 Very High Very High Very High
Autoimmune Disease 25 94.24 High High
Hematological Disease 6 93.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When MDCs and PDCs undergo phenotypic maturation certain factors, for instance CD83, CD40, HLA DR, B7H3 (CD276) and CCR7 are upregulated, whereas DCIR, ICOSL (CD275) [18], and several tissue retaining chemokine receptors (CCR1, CCR2, CCR3, CCR5 and, CCR8) are down modulated and as a consequence the DCs will migrate to the local lymphatic tissue [19], [20], [21].
Positive_regulation (upregulated) of CCR7 associated with chemokine
1) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.58 Pain Relevance 0.15
CCR6 and CCR7 were increased on both MDCs and PDCs.
Positive_regulation (increased) of CCR7
2) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.98 Pain Relevance 0.14
Chemokine (C-C motif) receptor 7 (CCR7) was clearly upregulated upon Apo-Nec phagocytosis in DCs from all patients (Figure 1B) and this correlated with DCs migration towards MIP-3 beta in vitro.
Positive_regulation (upregulated) of CCR7 associated with chemokine
3) Confidence 0.40 Published 2008 Journal J Transl Med Section Body Doc Link PMC2265680 Disease Relevance 0.13 Pain Relevance 0.05
The lack of an upregulated CCR7-CCL19 axis in this group would exacerbate the impact of enhanced DC production and mobilization into blood by limiting mDC exodus into tissues.
Positive_regulation (upregulated) of CCR7 in blood
4) Confidence 0.34 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.39 Pain Relevance 0.10
In this study we showed that CCL21 up-regulation was not related with an increase of CCR7+ infiltrating lymphocytes but it was associated with the disappearance of Langerin+ cells from the epidermis.
Positive_regulation (increase) of CCR7 in epidermis
5) Confidence 0.34 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0.61 Pain Relevance 0.18
The TLR9 ligation on PDCs induced a mature phenotype with upregulation of CD40, CD83, CD86, CCR7, PDL-1, ICOSL and CCR5 and decreased B7H3 and DCIR (Figure 9).
Positive_regulation (upregulation) of CCR7 in PDL-1
6) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.30 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Spec (clear) Positive_regulation (activation) of CCR7 in CD86
7) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.73 Pain Relevance 0.06
The profile for PDCs, both pre and post surgery, showed increased levels for CCR6 (pre: median 405, post: median 440, control: median 166) (Figure 5C) and CCR7 (pre: median 3.2, post: median 3.2, control: median 0) (Figure 5D), but no effect was seen for CCR5 (Figure 5B).
Positive_regulation (increased) of CCR7
8) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.46 Pain Relevance 0.26
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (enhanced) of CCR7 in CD86
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (levels) of CCR7 in CD86
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.60 Pain Relevance 0.03
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (increased) of CCR7 in CD86
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.61 Pain Relevance 0.03
CCR7, but not to induce full maturation and may even induce the immune inhibitory molecule indoleamine 2,3 dioxygenase expression in DCs [52], [53].
Spec (may) Positive_regulation (induce) of CCR7
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.52 Pain Relevance 0.12
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Spec (clear) Positive_regulation (activation) of CCR7 in CD86
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.72 Pain Relevance 0.06
Semi-mature profiles were seen for both MDCs and PDCs matured with PC021 plasma with significantly increased levels for CD40, CD83, CD86, and CCR7 on MDCs and enhanced levels of CD40, CD86, CD83, CCR7, and PDL-1 on PDCs (Figure 10B), which was a more clear activation than that achieved by pooled plasma.
Positive_regulation (increased) of CCR7 in CD86
14) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.62 Pain Relevance 0.03
RESULTS: Patients with CP had a skewed distribution of T lymphocytes, with an increased level of CCR7+/CD45RA- central memory T lymphocytes compared to healthy controls.
Positive_regulation (increased) of CCR7 in T lymphocytes
15) Confidence 0.27 Published 2005 Journal Pancreatology Section Body Doc Link 15849488 Disease Relevance 0.09 Pain Relevance 0
One of the most important mechanisms is the up-regulation of CCR7 in the emigrating DC, which seems to be crucial for these cells to reach PLN through lymphatics [10].
Positive_regulation (up-regulation) of CCR7
16) Confidence 0.26 Published 2004 Journal BMC Immunol Section Body Doc Link PMC419342 Disease Relevance 0 Pain Relevance 0.12
The lack of mDC accumulation in lymph nodes despite evidence for enhanced CCR7/CCL19-mediated recruitment in progressive infection led us to suspect that lymph node mDC were dying at an increased rate in these tissues.
Positive_regulation (enhanced) of CCR7 in lymph nodes associated with infection
17) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.04 Pain Relevance 0
Together with our findings in blood, these data suggest that mDC are recruited to lymph nodes in progressive disease via an enhanced CCR7/CCL19 pathway, but that expanded mDC recruitment fails to result in mDC accumulation.


Positive_regulation (enhanced) of CCR7 in lymph nodes associated with disease
18) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 0.87 Pain Relevance 0
The lack of mDC accumulation in lymph nodes despite evidence for enhanced CCR7/CCL19-mediated recruitment in progressive infection led us to suspect that lymph node mDC were dying at an increased rate in these tissues.
Positive_regulation (accumulation) of CCR7 in lymph nodes associated with infection
19) Confidence 0.25 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC3009592 Disease Relevance 1.06 Pain Relevance 0
These data suggest that mDC are mobilized in SIV infection but that an increase in the CCR7-CCL19 chemokine axis associated with high virus burden in progressive infection promotes exodus of activated mDC from blood into lymph nodes where they die from apoptosis.
Positive_regulation (increase) of CCR7 in blood associated with chemokine, apoptosis and infection
20) Confidence 0.23 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009592 Disease Relevance 1.29 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox