INT126521

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 5.90
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapkapk2) kinase activity (Mapkapk2) response to stress (Mapkapk2)
cytoplasm (Mapkapk2)
Anatomy Link Frequency
endothelial cells 2
embryos 1
MDA-MB-231 1
kidney 1
Mapkapk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 4 99.40 Very High Very High Very High
fibrosis 105 55.08 Quite High
Inflammation 123 53.68 Quite High
cytokine 56 50.80 Quite High
ischemia 28 40.16 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
chemokine 10 5.00 Very Low Very Low Very Low
Angina 7 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 7 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 112 98.32 Very High Very High Very High
Myocardial Infarction 483 97.24 Very High Very High Very High
Diabetes Mellitus 651 97.12 Very High Very High Very High
Ventricular Remodeling 70 96.92 Very High Very High Very High
Breast Cancer 5 96.88 Very High Very High Very High
Cancer 144 96.76 Very High Very High Very High
Targeted Disruption 27 95.76 Very High Very High Very High
Stress 50 89.36 High High
Heart Rate Under Development 14 67.40 Quite High
INFLAMMATION 132 53.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Treatment of 8-cell-stage embryos with SB203580 and SB220025 (CSAIDtrade mark) resulted in a blockade of preimplantation development, loss of rhodamine phalloidin fluorescence, MK-p (phosphorylated MAPKAPK2/3), HSP-p (phosphorylated HSP25/27) and a redistribution of alpha-catenin immunofluorescence by 12 h of treatment.
Positive_regulation (resulted) of MAPKAPK2 in embryos
1) Confidence 0.49 Published 2005 Journal Biol. Cell Section Body Doc Link 15850458 Disease Relevance 0 Pain Relevance 0
We employed the 460 mOsm culture medium treatment for these experiments since we had now established that this treatment was sufficient to significantly increase phospho-MAPKAPK2 immunofluorescence levels.
Positive_regulation (increase) of MAPKAPK2
2) Confidence 0.39 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Tilly et al., [39]described a 2-fold increase in the enzymatic activity of MAPKAPK2 at 10 minutes after 820 mOsm mannitol-induced hyperosmotic treatment in human intestine 407 cells [39]; while Watts et al. demonstrated in rat medullary thick ascending limb (MTAL) kidney cells a 2.3-fold increase in ATF-2 (downstream transcription factor of p38 MAPK) phosphorylation with 0.3 M mannitol following 15 minutes treatment [40].
Positive_regulation (increase) of MAPKAPK2 in kidney
3) Confidence 0.39 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
This is in contrast to the 1.4 M sucrose (1800 mOsm) and 0.2 M sorbitol (460 mOsm) treatments in which a significant increase in phospho-MAPKAPK2 immunofluorescence was detected at two treatment time-points.
Positive_regulation (increase) of MAPKAPK2
4) Confidence 0.39 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.23 Pain Relevance 0
At both 1800 mOsm and 460 mOsm hyperosmotic treatment conditions, the addition of glycerol to KSOMaa culture medium did not result in a significant increase in phospho-MAPKAPK2 immunofluorescence in blastocysts.
Positive_regulation (increase) of MAPKAPK2
5) Confidence 0.34 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.23 Pain Relevance 0
The overexpression of constitutively active MK2 results in increased HuR cytoplasmic localization in the MDA-MB-231 invasive breast cancer line [129].
Positive_regulation (overexpression) of MK2 in MDA-MB-231 associated with breast cancer
6) Confidence 0.24 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 1.01 Pain Relevance 0.15
The therapy significantly reduced the ventricular remodeling as evidenced by the significant reduction in the collagenous fibrotic tissue and improvement in the myocardial functions in conjunction with significant increase in the levels of VEGF and its receptor Flk-1, Ang-1 and its receptor Tie-2, p-MK2, and antiapoptotic survivin.
Positive_regulation (increase) of MK2 associated with fibrosis and ventricular remodeling
7) Confidence 0.15 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.16 Pain Relevance 0.03
Similarly, the therapy significantly increased the levels of phosphorylated MK2 (p-MK2) 4 days after intervention in both the DVAMI and CVAMI groups compared with the DLZMI and CLZMI groups, respectively.
Positive_regulation (increased) of MK2
8) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.82 Pain Relevance 0
mice failed to bring about significant phosphorylation of MK2 and increase DNA binding activity of NF?
Neg (failed) Positive_regulation (increase) of MK2
9) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.30 Pain Relevance 0
It was also reported that MK2 activation plays an essential role in VEGF-induced actin reorganization, migration, and tubule formation in endothelial cells (33).
Positive_regulation (activation) of MK2 in endothelial cells
10) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.46 Pain Relevance 0
Recently, we have shown that ischemic preconditioning induces VEGF expression followed by Flk-1 activation, thereby activating an angiogenic signaling cascade by the activation of p38MAPK and MK2 leading to the activation of NF?
Positive_regulation (activation) of MK2
11) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.35 Pain Relevance 0
Similarly, the therapy significantly increased the levels of phosphorylated MK2 (p-MK2) 4 days after intervention in both the DVAMI and CVAMI groups compared with the DLZMI and CLZMI groups, respectively.
Positive_regulation (increased) of MK2
12) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.82 Pain Relevance 0
The VEGF/Flk-1–induced effects on endothelial cell migration through p38 mitogen-activated protein kinase (MAPK) activation are mediated primarily by phosphorylation and activation of the p38MAPK substrate MK2 (31,32).
Positive_regulation (activation) of MK2 in endothelial cell
13) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.53 Pain Relevance 0

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