INT126522

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 3.80
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapkapk2) kinase activity (Mapkapk2) response to stress (Mapkapk2)
cytoplasm (Mapkapk2)
Anatomy Link Frequency
embryos 2
Mapkapk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 100.00 Very High Very High Very High
Inflammatory response 1 90.44 High High
cytokine 15 88.36 High High
adenocard 1 83.52 Quite High
cINOD 5 57.52 Quite High
fibrosis 45 5.00 Very Low Very Low Very Low
ischemia 12 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Percutaneous transluminal coronary angioplasty 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 6 99.16 Very High Very High Very High
Diabetes Mellitus 279 98.56 Very High Very High Very High
Myocardial Infarction 207 97.24 Very High Very High Very High
Stress 33 96.64 Very High Very High Very High
Aging 1 93.28 High High
INFLAMMATION 9 90.44 High High
Carcinoma 4 61.36 Quite High
Ventricular Remodeling 30 50.00 Quite Low
Tuberous Sclerosis 11 50.00 Quite Low
Death 7 39.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest a solute specificity in the induction of CCM2, which agrees with the induction of p38 MAPK activity and phosphorylation of MAPKAPK2 described above.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of MAPKAPK2
1) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Our results clearly demonstrate that hyperosmotic treatment during culture increased p38 MAPK activity as assessed by increased phosphorylation of its specific downstream substrate, MAPKAPK2.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of MAPKAPK2
2) Confidence 0.59 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.29 Pain Relevance 0
RESULTS: Treatment of 8-cell-stage embryos with SB203580 and SB220025 (CSAIDtrade mark) resulted in a blockade of preimplantation development, loss of rhodamine phalloidin fluorescence, MK-p (phosphorylated MAPKAPK2/3), HSP-p (phosphorylated HSP25/27) and a redistribution of alpha-catenin immunofluorescence by 12 h of treatment.
Positive_regulation (resulted) of Phosphorylation (phosphorylated) of MAPKAPK2 in embryos
3) Confidence 0.49 Published 2005 Journal Biol. Cell Section Body Doc Link 15850458 Disease Relevance 0 Pain Relevance 0
While the increased p38 MAPK activity and phosphorylation of MAPKAPK2 in itself is not a novel discovery, the responsiveness of p38 MAPK to hyperosmotic stress has not until now been demonstrated to occur during preimplantation development.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of MAPKAPK2 associated with stress
4) Confidence 0.42 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.25 Pain Relevance 0
Similarly, the therapy significantly increased the levels of phosphorylated MK2 (p-MK2) 4 days after intervention in both the DVAMI and CVAMI groups compared with the DLZMI and CLZMI groups, respectively.
Positive_regulation (increased) of Phosphorylation (phosphorylated) of MK2
5) Confidence 0.10 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.82 Pain Relevance 0
Similarly, we observed a significant increase in the phosphorylation of MK2, 2 days after the treatment in the diabetic animals that received the therapy (DVAMI, 3.9-fold), compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 5C and D).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MK2 associated with diabetes mellitus and myocardial infarction
6) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.95 Pain Relevance 0
We observed a significant increase in the phosphorylation of MK2, 2 days after the treatment in the nondiabetic animals that received the therapy (CVAMI, 1.3-fold), compared with the Ad.LacZ-treated nondiabetic MI (CLZMI) group (Fig. 5C and D).
Positive_regulation (increase) of Phosphorylation (phosphorylation) of MK2 associated with myocardial infarction
7) Confidence 0.09 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.07 Pain Relevance 0
The phosphorylation of tuberin by Akt and MK2 promotes the binding of tuberin with 14-3-3 proteins. 14-3-3 proteins are members of a group of proteins that specifically interact with phosphorylated proteins, facilitating the phosphorylation-dependent control of protein activity [83].
Positive_regulation (promotes) of Phosphorylation (phosphorylation) of MK2
8) Confidence 0.06 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0.04
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.
Positive_regulation (promotes) of Phosphorylation (Phosphorylation) of MAPK-activated protein kinase 2 associated with inflammation
9) Confidence 0.04 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16278218 Disease Relevance 0.42 Pain Relevance 0.23

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