INT126523

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Context Info
Confidence 0.79
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 19
Disease Relevance 7.76
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Mapkapk2) kinase activity (Mapkapk2) response to stress (Mapkapk2)
cytoplasm (Mapkapk2)
Anatomy Link Frequency
myocardium 1
embryos 1
endothelial cell 1
Mapkapk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 224 100.00 Very High Very High Very High
cytokine 89 98.72 Very High Very High Very High
Arthritis 7 96.72 Very High Very High Very High
Inflammatory response 10 87.96 High High
adenocard 1 83.52 Quite High
fibrosis 106 64.16 Quite High
cINOD 16 55.04 Quite High
ischemia 28 40.96 Quite Low
chemokine 30 36.92 Quite Low
metalloproteinase 19 28.08 Quite Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 651 98.56 Very High Very High Very High
Apoptosis 35 97.76 Very High Very High Very High
Shock 11 97.60 Very High Very High Very High
Myocardial Infarction 483 97.48 Very High Very High Very High
Sepsis 2 97.42 Very High Very High Very High
Arthritis 6 96.72 Very High Very High Very High
Stress 99 96.64 Very High Very High Very High
Targeted Disruption 31 96.52 Very High Very High Very High
Animal Disease Models 1 96.02 Very High Very High Very High
INFLAMMATION 243 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Treatment of 8-cell-stage embryos with SB203580 and SB220025 (CSAIDtrade mark) resulted in a blockade of preimplantation development, loss of rhodamine phalloidin fluorescence, MK-p (phosphorylated MAPKAPK2/3), HSP-p (phosphorylated HSP25/27) and a redistribution of alpha-catenin immunofluorescence by 12 h of treatment.
Phosphorylation (phosphorylated) of MAPKAPK2 in embryos
1) Confidence 0.79 Published 2005 Journal Biol. Cell Section Body Doc Link 15850458 Disease Relevance 0 Pain Relevance 0
The RSS of phosphorylated MAPKAPK2 immunofluorescence in blastocysts cultured in KSOMaa + 1.4% glycerol did not differ from KSOMaa only controls (Figure 4S).
Phosphorylation (phosphorylated) of MAPKAPK2
2) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
While the increased p38 MAPK activity and phosphorylation of MAPKAPK2 in itself is not a novel discovery, the responsiveness of p38 MAPK to hyperosmotic stress has not until now been demonstrated to occur during preimplantation development.
Phosphorylation (phosphorylation) of MAPKAPK2 associated with stress
3) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.25 Pain Relevance 0
Furthermore, p38 MAPK regulates F-actin polymerization during preimplantation development via phosphorylation of downstream substrates MAPKAPK2 and PRAK/MAPKAPK5, and subsequently through the small heat shock proteins, HSPB1/2 [23,24].
Phosphorylation (phosphorylation) of MAPKAPK2 associated with shock
4) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.10 Pain Relevance 0
These results suggest a solute specificity in the induction of CCM2, which agrees with the induction of p38 MAPK activity and phosphorylation of MAPKAPK2 described above.
Phosphorylation (phosphorylation) of MAPKAPK2
5) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
Our results clearly demonstrate that hyperosmotic treatment during culture increased p38 MAPK activity as assessed by increased phosphorylation of its specific downstream substrate, MAPKAPK2.
Phosphorylation (phosphorylation) of MAPKAPK2
6) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0.29 Pain Relevance 0
Interestingly, the 1.74-fold increase in CCM2 immunofluorescence we observed mirrored the 1.75-fold increase in p38 MAPK activity assessed by MAPKAPK2 phosphorylation.
Phosphorylation (phosphorylation) of MAPKAPK2
7) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
0.05) in RSS of phosphorylated MAPKAPK2 immunofluorescence (1.75 ± 0.18, n = 33) when compared to blastocysts cultured in normal KSOMaa culture medium (1.00 ± 0.11, n = 33) or KSOMaa + 1.4% glycerol (1.16 ± 0.13, n = 34) (Figure 4S).
Phosphorylation (phosphorylated) of MAPKAPK2
8) Confidence 0.69 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC1781062 Disease Relevance 0 Pain Relevance 0
In vitro evidence shows that TTP can be directly phosphorylated by either p38 or MK2 potentially modifying mRNA destabilizing activity of TTP [121, 122].
Phosphorylation (phosphorylated) of MK2
9) Confidence 0.33 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2921490 Disease Relevance 0.32 Pain Relevance 0.13
Administration of SB203580 has beneficial effects in animal disease models such as collagen-induced arthritis and endotoxin-induced septic shock (Lee et al 1999). p38 has also been shown to upregulate cytokine production by several independent mechanisms, including direct phosphorylation of transcription factors, and direct or indirect (through downstream kinases such as MAPKAPK2) stabilization and increased translation of mRNAs containing 3% untranslated region adenylate/uridylate-rich elements (AREs) by phosphorylation of AREbinding proteins (Dean et al 2004; Briata et al 2005; Hitti et al 2006).
Phosphorylation (phosphorylation) of MAPKAPK2 associated with animal disease models, sepsis, cytokine and arthritis
10) Confidence 0.25 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.98 Pain Relevance 0.35
Effect of gene therapy on the phosphorylation of MK2.
Phosphorylation (phosphorylation) of MK2
11) Confidence 0.17 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.14 Pain Relevance 0
Similarly, the therapy significantly increased the levels of phosphorylated MK2 (p-MK2) 4 days after intervention in both the DVAMI and CVAMI groups compared with the DLZMI and CLZMI groups, respectively.
Phosphorylation (phosphorylated) of MK2
12) Confidence 0.13 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.76 Pain Relevance 0
B in the diabetic ischemic myocardium, thereby confirming improvement in the angiogenic signaling mechanism associated with increase in the expression of VEGF and Ang-1 and phosphorylation of MK2.
Phosphorylation (phosphorylation) of MK2 in myocardium associated with diabetes mellitus
13) Confidence 0.13 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.72 Pain Relevance 0.07
mice failed to bring about significant phosphorylation of MK2 and increase DNA binding activity of NF?
Phosphorylation (phosphorylation) of MK2
14) Confidence 0.13 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.30 Pain Relevance 0
We observed a significant increase in the phosphorylation of MK2, 2 days after the treatment in the nondiabetic animals that received the therapy (CVAMI, 1.3-fold), compared with the Ad.LacZ-treated nondiabetic MI (CLZMI) group (Fig. 5C and D).
Phosphorylation (phosphorylation) of MK2 associated with myocardial infarction
15) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.06 Pain Relevance 0
The VEGF/Flk-1–induced effects on endothelial cell migration through p38 mitogen-activated protein kinase (MAPK) activation are mediated primarily by phosphorylation and activation of the p38MAPK substrate MK2 (31,32).
Phosphorylation (phosphorylation) of MK2 in endothelial cell
16) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.53 Pain Relevance 0
Similarly, we observed a significant increase in the phosphorylation of MK2, 2 days after the treatment in the diabetic animals that received the therapy (DVAMI, 3.9-fold), compared with the Ad.LacZ-treated diabetic MI (DLZMI) group (Fig. 5C and D).
Phosphorylation (phosphorylation) of MK2 associated with diabetes mellitus and myocardial infarction
17) Confidence 0.12 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 0.90 Pain Relevance 0
The phosphorylation of tuberin by Akt and MK2 promotes the binding of tuberin with 14-3-3 proteins. 14-3-3 proteins are members of a group of proteins that specifically interact with phosphorylated proteins, facilitating the phosphorylation-dependent control of protein activity [83].
Phosphorylation (phosphorylation) of MK2
18) Confidence 0.09 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0 Pain Relevance 0.04
Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.
Phosphorylation (Phosphorylation) of MAPK-activated protein kinase 2 associated with inflammation
19) Confidence 0.07 Published 2006 Journal J. Biol. Chem. Section Title Doc Link 16278218 Disease Relevance 0.41 Pain Relevance 0.23

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