INT126524

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.14
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Mapk7) cytosol (Mapk7) nucleus (Mapk7)
cell cycle (Mapk7) kinase activity (Mapk7) cytoplasm (Mapk7)
Mapk7 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 1 97.04 Very High Very High Very High
Inflammation 4 92.24 High High
cytokine 9 68.32 Quite High
cINOD 3 66.64 Quite High
Neuropeptide 8 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Cholecystokinin 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 2 97.64 Very High Very High Very High
Apoptosis 11 96.48 Very High Very High Very High
Death 5 95.94 Very High Very High Very High
Non-small-cell Lung Cancer 48 95.80 Very High Very High Very High
INFLAMMATION 5 92.24 High High
Lymphatic System Cancer 1 89.36 High High
Lung Cancer 78 81.72 Quite High
Cancer 51 81.28 Quite High
Metastasis 16 75.60 Quite High
Shock 1 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.
Positive_regulation (activation) of ERK5 associated with apoptosis, death and palliative
1) Confidence 0.45 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.44 Pain Relevance 0.10
BACKGROUND INFORMATION: The MAPK (mitogen-activated protein kinase) superfamily of proteins consists of four separate signalling cascades: the c-Jun N-terminal kinase or stress-activated protein kinases (JNK/SAPK); the ERKs (extracellular-signal-regulated kinases); the ERK5 or big MAPK1; and the p38 MAPK group of protein kinases, all of which are highly conserved.
Positive_regulation (conserved) of ERK5 associated with stress
2) Confidence 0.30 Published 2005 Journal Biol. Cell Section Abstract Doc Link 15850458 Disease Relevance 0.24 Pain Relevance 0.10
activity through activation of ERK5, and that this increase in
Positive_regulation (activation) of ERK5
3) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.54 Pain Relevance 0.07
demonstrated that flow-mediated activation of ERK5, a member of the MAP kinase
Positive_regulation (activation) of ERK5
4) Confidence 0.22 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396386 Disease Relevance 0.92 Pain Relevance 0.05

General Comments

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