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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.81
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Mapk14 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 27 99.44 Very High Very High Very High
Spinal cord 6 98.44 Very High Very High Very High
intrathecal 10 84.00 Quite High
allodynia 39 83.84 Quite High
substance P 9 74.88 Quite High
Nerve growth factor 45 69.92 Quite High
Trk A 11 67.84 Quite High
Inflammatory response 13 60.76 Quite High
Inflammation 42 50.00 Quite Low
Cold hyperalgesia 1 48.44 Quite Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 36 99.44 Very High Very High Very High
Diabetes Mellitus 44 99.16 Very High Very High Very High
Neuropathic Pain 48 83.84 Quite High
INFLAMMATION 65 60.36 Quite High
Hyperalgesia 7 48.44 Quite Low
Pain 15 24.56 Low Low
Nervous System Injury 3 6.68 Low Low
Inflammatory Pain 2 5.60 Low Low
Lyme Disease 13 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All these effects of p38 MAPK inhibition were reversed upon removal of the inhibitor, and development resumed in a delayed but normal manner to the blastocyst stage.
Regulation (effects) of Negative_regulation (inhibition) of p38 MAPK
1) Confidence 0.41 Published 2005 Journal Biol. Cell Section Body Doc Link 15850458 Disease Relevance 0 Pain Relevance 0
Regardless, our findings support the use of p38 inhibitors for treating PDN of type 2 diabetes.
Regulation (use) of Negative_regulation (inhibitors) of p38 associated with painful diabetic neuropathy and diabetes mellitus
2) Confidence 0.38 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.75 Pain Relevance 1.08
The PI3K inhibitors wortmannin and Ly294002 were used to determine whether elevated AKT activity was responsible for the decreased phospho-p38 levels in CD14?
Spec (whether) Regulation (responsible) of Spec (whether) Negative_regulation (decreased) of p38
3) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2781632 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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