INT126532

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 2.66
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 3 98.40 Very High Very High Very High
cINOD 3 86.56 High High
Inflammation 3 83.36 Quite High
Pain 1 82.68 Quite High
Cannabinoid 1 67.84 Quite High
palliative 1 25.00 Low Low
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 25 99.76 Very High Very High Very High
Neurological Disease 1 96.80 Very High Very High Very High
Metastasis 2 91.60 High High
Breast Cancer 23 90.72 High High
INFLAMMATION 3 86.00 High High
Pain 1 82.68 Quite High
Death 2 76.00 Quite High
Disease 8 73.00 Quite High
Renal Disease 1 71.00 Quite High
Thrombosis 1 68.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, it has been suggested that COX-2 inhibitors may contribute to maintain high levels of chemotherapeutics in tumor tissues by preventing the overexpression of the multidrug resistance protein MDR1/P-gp.
Negative_regulation (preventing) of Gene_expression (overexpression) of multidrug resistance protein MDR1 associated with cancer and cox-2 inhibitor
1) Confidence 0.41 Published 2005 Journal Brain Res. Brain Res. Rev. Section Abstract Doc Link 15850674 Disease Relevance 0.88 Pain Relevance 0.59
Herein we review general mechanisms of drug resistance, including multidrug resistance by P-glycoprotein and the multidrug resistance protein family in association with specific agents and their metabolism, emergence of refractory tumors associated with multiple resistance mechanisms, and resistance factors unique to host-tumor-drug interactions.
Negative_regulation (metabolism) of Gene_expression (resistance) of multidrug resistance associated with cancer
2) Confidence 0.41 Published 2007 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 17993229 Disease Relevance 1.77 Pain Relevance 0

General Comments

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