INT126534

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 28
Disease Relevance 14.32
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ROCK1) signal transduction (ROCK1) Golgi apparatus (ROCK1)
cytoskeleton (ROCK1) cytoplasm (ROCK1)
Anatomy Link Frequency
OAB 1
MDA-MB-231 1
ROCK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 5 99.88 Very High Very High Very High
antagonist 14 99.70 Very High Very High Very High
agonist 73 97.74 Very High Very High Very High
cytokine 30 96.68 Very High Very High Very High
Mechanotransduction 88 92.56 High High
Abeta 1 87.96 High High
headache 7 82.68 Quite High
cINOD 5 79.92 Quite High
depression 13 78.24 Quite High
cva 98 64.32 Quite High
Disease Link Frequency Relevance Heat
Metastasis 253 99.88 Very High Very High Very High
Breast Cancer 66 99.66 Very High Very High Very High
Inflammatory Bowel Disease 156 99.64 Very High Very High Very High
Increased Venous Pressure Under Development 16 99.40 Very High Very High Very High
Cancer 560 99.30 Very High Very High Very High
Overactive Bladder 15 97.96 Very High Very High Very High
Stress 45 96.68 Very High Very High Very High
Cardiovascular Disease 18 96.48 Very High Very High Very High
Adhesions 36 95.40 Very High Very High Very High
Osteolysis 33 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pomalidomide effect on actin cytoskeleton was blocked by the ROCK1 inhibitor, but not Rac1 inhibitor.
Negative_regulation (inhibitor) of ROCK1
1) Confidence 0.49 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.17 Pain Relevance 0.07
Consistent with the activation of Rho GTPases, we found that pomalidomide enhanced F-actin formation, stabilized microtubules, and increased cell migration, all of which were blocked by selective inhibitors of ROCK1 and Rac1.
Negative_regulation (inhibitors) of ROCK1
2) Confidence 0.49 Published 2009 Journal Blood Section Abstract Doc Link 19417207 Disease Relevance 0.17 Pain Relevance 0.08
Inhibition of p160 ROCK completely blocked LPA and S1P stimulated effects, while both phospholipids could still mediate cell aggregation and rounding following inactivation of EGFR, or ERK.
Negative_regulation (Inhibition) of ROCK
3) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Notably, the basal growth of hES-NEP cells was also inhibited by EGFR and MAP kinase inhibitors but not p160 ROCK inhibitor, suggesting that basal growth is mediated by a similar pathway, although not necessarily initiated by LPA or S1P.
Negative_regulation (inhibitor) of ROCK
4) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.16 Pain Relevance 0
The growth responses to LPA and S1P in these cells were completely inhibited by Ptx and inhibitors of EGF receptors and ERK Map kinases, but not by inhibitors of p160 ROCK.
Neg (not) Negative_regulation (inhibitors) of ROCK
5) Confidence 0.43 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.17 Pain Relevance 0
M), and the p160ROCK inhibitor Y27632 (10 ?
Negative_regulation (inhibitor) of p160ROCK
6) Confidence 0.32 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Interestingly, members of this pathway, ROCK1 and LIM, were down-regulated in both IBD subtypes in our PCR experiments (but not in inflamed DCs), which might indicate a potential decline in cell migration and an impaired ability to maintain epithelial integrity in IBD.
Negative_regulation (regulated) of ROCK1 associated with inflammatory bowel disease
7) Confidence 0.29 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.13 Pain Relevance 0
Interestingly, members of this pathway, ROCK1 and LIM, were down-regulated in both IBD subtypes in our PCR experiments (but not in inflamed DCs), which might indicate a potential decline in cell migration and an impaired ability to maintain epithelial integrity in IBD.
Negative_regulation (down) of ROCK1 associated with inflammatory bowel disease
8) Confidence 0.29 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 1.12 Pain Relevance 0
The therapeutic potential of several other agents, such as alpha(3)-adrenoceptor agonists, purinergic receptor antagonists, phosphodiesterase inhibitors, neurokinin-1 receptor antagonists, opioids, and Rho-kinase inhibitors, is also under investigation for the treatment of OAB.
Negative_regulation (inhibitors) of Rho-kinase in OAB associated with antagonist, agonist, overactive bladder and opioid
9) Confidence 0.23 Published 2007 Journal BJU Int. Section Abstract Doc Link 17922784 Disease Relevance 0.59 Pain Relevance 0.37
Inhibition of actomyosin contractility by blebbistatin and inhibition of ROCK-I by Y-27632 induced a significant decrease in PTHrP mRNA expression in both MDA-MB-231 and RWGT2 cells (Figure 4B), suggesting that the upregulation of PTHrP on rigid substrates is mediated by ROCK.
Negative_regulation (inhibition) of ROCK-I in MDA-MB-231
10) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.05 Pain Relevance 0.12
Intriguingly, this appears to involve the inhibition of the activity of small GTPase Rho and its effector, the Rho-associated kinase, ROCK.
Negative_regulation (inhibition) of ROCK
11) Confidence 0.18 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15850769 Disease Relevance 0.50 Pain Relevance 0.20
As shown in Figure 6, blocking ROCK either pharmacologically or genetically inhibits most of the incremental PTHrP expression resulting from treatment with exogenous TGF-ß.
Negative_regulation (blocking) of ROCK
12) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.38 Pain Relevance 0.03
Inhibition of ROCK using both pharmacological and genetic models decreased PTHrP expression.
Negative_regulation (Inhibition) of ROCK
13) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.61 Pain Relevance 0
Inhibition of Rho-associated kinase (ROCK) using both pharmacological and genetic approaches decreased PTHrP expression.
Negative_regulation (Inhibition) of ROCK
14) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.82 Pain Relevance 0
Inhibition of Rho-associated kinase (ROCK) using both pharmacological and genetic approaches decreased PTHrP expression.
Negative_regulation (Inhibition) of Rho-associated kinase
15) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.82 Pain Relevance 0
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
Negative_regulation (inhibition) of ROCK
16) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.55 Pain Relevance 0
Furthermore, cells expressing a dominant negative form of the TGF-ß receptor did not respond to substrate rigidity, and inhibition of ROCK decreased PTHrP expression induced by exogenous TGF-ß.
Negative_regulation (inhibition) of ROCK
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2981576 Disease Relevance 0.80 Pain Relevance 0
Taken together, these observations suggest that inhibiting ROCK or the pathway it stimulates may be an effective approach for treatment of breast cancer metastases in the clinic.
Negative_regulation (inhibiting) of ROCK associated with breast cancer and metastasis
18) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 1.15 Pain Relevance 0.04
Inhibition of ROCK in the presence of exogenous TGF-ß
Negative_regulation (Inhibition) of ROCK
19) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.19 Pain Relevance 0.04
Additionally, ROCK expression is higher in metastatic human mammary tumors relative to non-metastatic tumors, and inhibition of ROCK signaling decreases cell proliferation in vitro and metastasis to bone in vivo [12].
Negative_regulation (inhibition) of ROCK associated with cancer and metastasis
20) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2981576 Disease Relevance 0.94 Pain Relevance 0

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