INT126535

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.48
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (RHO) plasma membrane (RHO) signal transducer activity (RHO)
Anatomy Link Frequency
ganglion cell 2
RHO (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 16 99.50 Very High Very High Very High
Abeta 13 87.96 High High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 99.08 Very High Very High Very High
Apoptosis 2 95.92 Very High Very High Very High
INFLAMMATION 3 91.56 High High
Alzheimer's Dementia 6 88.92 High High
Aging 1 85.60 High High
Disease 2 76.76 Quite High
Stress 2 52.48 Quite High
Retinal Diseases 4 50.08 Quite High
Age-related Macular Degeneration 4 47.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intriguingly, this appears to involve the inhibition of the activity of small GTPase Rho and its effector, the Rho-associated kinase, ROCK.
Negative_regulation (inhibition) of Rho
1) Confidence 0.57 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15850769 Disease Relevance 0.49 Pain Relevance 0.20
A recent report indicated that NSAIDs could reduce Abeta42 by inhibition of the small GTPase Rho, and a single inhibitor of Rho kinase (ROCK) mimicked the effects of Abeta42-lowering NSAIDs.
Negative_regulation (inhibition) of Rho associated with cinod
2) Confidence 0.57 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16300630 Disease Relevance 0.17 Pain Relevance 0.56
This was supported by RT-PCR data where rhodopsin (photoreceptor specific) mRNA was reduced while Thy-1 and NF-L (ganglion cell specific) mRNAs were unaffected.
Negative_regulation (reduced) of rhodopsin in ganglion cell associated with ganglion cysts
3) Confidence 0.57 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.39 Pain Relevance 0
A recent report indicated that NSAIDs could reduce Abeta42 by inhibition of the small GTPase Rho, and a single inhibitor of Rho kinase (ROCK) mimicked the effects of Abeta42-lowering NSAIDs.
Negative_regulation (inhibitor) of Rho associated with cinod
4) Confidence 0.42 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16300630 Disease Relevance 0.16 Pain Relevance 0.56
Western blotting techniques showed that SNP caused a significant decrease in photoreceptor-specific markers (RET-P1, rhodopsin kinase), an increase in cleaved caspase-3, Bcl-2, and cleaved PARP proteins that are associated with apoptosis and no change in the ganglion cell specific marker, neurofilament (NF-L).
Negative_regulation (decrease) of rhodopsin in ganglion cell associated with ganglion cysts and apoptosis
5) Confidence 0.18 Published 2007 Journal Brain Res. Bull. Section Abstract Doc Link 17562394 Disease Relevance 0.27 Pain Relevance 0

General Comments

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