INT126539

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.52
Pain Relevance 1.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Trpv1) plasma membrane (Trpv1) lipid metabolic process (Trpv1)
Anatomy Link Frequency
DRG 6
neuronal 2
CoAO 2
brain 2
Trpv1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal-cord stimulation 8 99.98 Very High Very High Very High
qutenza 64 99.62 Very High Very High Very High
medulla 7 99.52 Very High Very High Very High
dorsal root ganglion 6 97.52 Very High Very High Very High
Spinal cord 4 86.20 High High
ischemia 4 83.28 Quite High
Neurotransmitter 1 78.32 Quite High
Angina 1 75.88 Quite High
cerebral cortex 2 50.88 Quite High
substance P 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 8 97.52 Very High Very High Very High
Increased Venous Pressure Under Development 4 85.72 High High
Coronary Artery Disease 4 83.92 Quite High
Disease 1 78.60 Quite High
Fever 7 77.92 Quite High
Cv General 3 Under Development 1 75.88 Quite High
Myocardial Infarction 3 72.96 Quite High
Death 2 72.24 Quite High
INFLAMMATION 4 55.96 Quite High
Nociception 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another point of departure between TRPV1 expression in the DRG and the brain is that, neonatal capsaicin treatment in rats reduces expression of TRPV1 mRNA in the DRG, but not in the brain [16].
Negative_regulation (reduces) of Transcription (expression) of TRPV1 in brain associated with qutenza
1) Confidence 0.59 Published 2006 Journal Mol Pain Section Body Doc Link PMC1647269 Disease Relevance 0.14 Pain Relevance 0.42
Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.
Negative_regulation (reductions) of Transcription (levels) of TRPV1 in DRG associated with dorsal root ganglion and qutenza
2) Confidence 0.52 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.28 Pain Relevance 0.63
RESULTS: Baicalin was shown to down-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and under the latter temperature, the intracellular fluorescent intensity evoked by capsaicin was significantly decreased following incubation with baicalin in vitro.
Negative_regulation (decreased) of Transcription (expression) of TRPV1
3) Confidence 0.43 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20380875 Disease Relevance 0.11 Pain Relevance 0
RESULTS: Baicalin was shown to down-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and under the latter temperature, the intracellular fluorescent intensity evoked by capsaicin was significantly decreased following incubation with baicalin in vitro.
Negative_regulation (down) of Transcription (expression) of TRPV1
4) Confidence 0.43 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20380875 Disease Relevance 0.11 Pain Relevance 0
The results showed that 1 could up-regulate the mRNA expression levels of TRPV1 at both 37 and 39 degrees C, and its calcium-mediating function was significantly increased at 39 degrees C, all of which could not be blocked by pretreatment of the neuronal cells with ruthenium red, a general transient receptor potential (TRP) blocker, indicating that the action of 1 was achieved through a non-TRPA1 channel pathway.
Negative_regulation (blocked) of Transcription (expression) of TRPV1 in neuronal
5) Confidence 0.43 Published 2010 Journal J Asian Nat Prod Res Section Abstract Doc Link 20390747 Disease Relevance 0.24 Pain Relevance 0
Only SP mRNA was increased significantly in T4 and brainstem during CoAO, while SCS decreased the mRNA levels of SP, NK-1 and TRPV1 significantly in T4 and the brainstem.
Negative_regulation (decreased) of Transcription (levels) of TRPV1 in CoAO associated with medulla and spinal-cord stimulation
6) Confidence 0.42 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17714867 Disease Relevance 0.39 Pain Relevance 0.75
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Negative_regulation (detecting) of Transcription (expression) of vanilloid receptor 1 in DRG
7) Confidence 0.42 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0
All above cultured samples were processed for detecting expression of mRNA for SP, CGRP and vanilloid receptor 1 (VR1) of DRG neurons by RT-PCR, and VR1 protein expression by Western blot.
Negative_regulation (detecting) of Transcription (expression) of VR1 in DRG
8) Confidence 0.42 Published 2006 Journal Neuro Endocrinol. Lett. Section Body Doc Link 17187013 Disease Relevance 0.09 Pain Relevance 0
Moreover, expression of mRNA for the capsaicin receptor TRPv1, a marker of group IV fibers, was downregulated in DCM animals compared with controls.
Negative_regulation (downregulated) of Transcription (expression) of capsaicin receptor TRPv1
9) Confidence 0.17 Published 2005 Journal Circulation Section Body Doc Link 15851614 Disease Relevance 0.07 Pain Relevance 0

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