INT126560

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 20
Disease Relevance 6.43
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2RY2) aging (P2RY2) plasma membrane (P2RY2)
embryo development (P2RY2) lysosome (P2RY2) signal transducer activity (P2RY2)
Anatomy Link Frequency
brain 5
chondrocyte 1
pancreas 1
endothelium 1
cortex 1
P2RY2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 58 99.76 Very High Very High Very High
Inflammation 44 99.44 Very High Very High Very High
Hippocampus 54 98.04 Very High Very High Very High
adenocard 82 96.84 Very High Very High Very High
Mechanotransduction 26 96.44 Very High Very High Very High
Pyramidal cell 54 96.00 Very High Very High Very High
cerebral cortex 9 95.64 Very High Very High Very High
Chronic pancreatitis 6 94.76 High High
Kinase C 11 88.32 High High
Inflammatory mediators 3 88.00 High High
Disease Link Frequency Relevance Heat
Disease 17 99.60 Very High Very High Very High
INFLAMMATION 46 99.44 Very High Very High Very High
Pressure And Volume Under Development 5 99.12 Very High Very High Very High
Wound Healing 69 98.76 Very High Very High Very High
Cancer 9 98.76 Very High Very High Very High
Stress 19 98.60 Very High Very High Very High
Injury 134 98.20 Very High Very High Very High
Pancreatic Cancer 8 96.88 Very High Very High Very High
Pancreatitis 12 94.76 High High
Increased Venous Pressure Under Development 62 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Next, we examined whether A1R and P2Y2R are associated with one another in several brain regions using immunoprecipitation with anti-A1R followed by immunoblotting with both A1R and P2Y2R antibodies (Figure 3).
P2Y2R Binding (associated) of in brain
1) Confidence 0.44 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.23
As with many other agonists (for example, insulin), when Ap4A binds to its receptor, P2Y2-R, on the surface of a cell, the Ap4A-P2Y2-R complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes.
Ap4A-P2Y2-R Binding (binds) of associated with agonist
2) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.27 Pain Relevance 0.05
As with many other agonists (for example, insulin), when Ap4A binds to its receptor, P2Y2-R, on the surface of a cell, the Ap4A-P2Y2-R complex undergoes endocytosis and is subsequently attacked by intracellular lysosomal enzymes.
P2Y2-R Binding (receptor) of associated with agonist
3) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.27 Pain Relevance 0.05
P2Y2-R siRNA counteract the effect of Ap4A on corneal wound healing
P2Y2-R Binding (counteract) of associated with wound healing
4) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2695252 Disease Relevance 0.75 Pain Relevance 0
We have therefore defined tissue distribution and localization of the CD39 family of ectonucleotidases and associated P2R in human disease.
P2R Binding (associated) of associated with disease
5) Confidence 0.36 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.31 Pain Relevance 0.42
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
P2Y2R Binding (associated) of in cortex associated with hippocampus
6) Confidence 0.34 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.18
However, the heteromeric interaction of A1R and P2Y2R in situ in brain is still largely unknown.


P2Y2R Binding (interaction) of in brain
7) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Abstract Doc Link PMC3009664 Disease Relevance 0.08 Pain Relevance 0.25
The aim of the present study is to determine whether A1R and P2Y2R associate with each other in rat brain by co-immunoprecipitation and looking for receptor complexes via immunogold electron microscopy (IEM).


P2Y2R Binding (associate) of in brain
8) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.08
As in the transfected HEK293T cells, we observed clusters of different-sized gold particles at cytoplasmic membranes in cell bodies, indicating the presence of heteromeric complexes of endogenous A1R and P2Y2R in rat brain (Figure 4E-G).
P2Y2R Binding (complexes) of in brain
9) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.08
The present study provides the first detailed evidence of an interaction between endogenous A1R and P2Y2R in brains using co-immunoprecipitation and IEM.
P2Y2R Binding (interaction) of in brains
10) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.15
Total numbers of hetero-dimers observed on the cell surface and in the cytoplasm were obviously different (data not shown) and may reflect the process of receptor maturation and association of the A1R-P2Y2R complex.
A1R-P2Y2R Binding (association) of
11) Confidence 0.32 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.14
Heightened expression patterns and localization patterns of CD39, P2X7, and P2Y2 infer associations with chronic inflammation and neoplasia of the pancreas.
P2Y2 Binding (associations) of in pancreas associated with inflammation and cancer
12) Confidence 0.31 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16920697 Disease Relevance 1.23 Pain Relevance 0.32
Alternatively, interactions between CD47/IAP, integrins, and P2Y2Rs [34], which recently have been demonstrated to be involved in chondrocyte and bone cell mechanotransduction [35,36], may be important for coupling the P2Y2R to Go.
P2Y2Rs Binding (interactions) of in chondrocyte associated with mechanotransduction
13) Confidence 0.22 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374443 Disease Relevance 0.06 Pain Relevance 0.16
The P2 receptors can in turn be divided into two families (ligand-gated P2X and the G protein-coupled P2Y receptors).
P2Y Binding (ligand) of
14) Confidence 0.18 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671790 Disease Relevance 1.11 Pain Relevance 0.19
It is released upon stimulation of the endothelium by acetylcholine, thrombin and mechanical stress and can be cleaved into either ATP or UTP to stimulate both P2X1 and P2Y2 receptors on VSMC resulting in increased blood pressure [88].
P2Y2 Binding (receptors) of in endothelium associated with stress and pressure and volume under development
15) Confidence 0.17 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.07 Pain Relevance 0.07
B, for example P2Y2, can mediate an overall inhibition of NF?
P2Y2 Binding (example) of
16) Confidence 0.15 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0.07 Pain Relevance 0
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
P2Y2R Binding (associated) of in cerebellum associated with hippocampus
17) Confidence 0.11 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.18
Moreover, in these same regions, anti-A1Rs were capable of co-precipitating P2Y2R (Figure 3D), indicating that A1R and P2Y2R are associated with one another in rat cortex, cerebellum, and hippocampus.
P2Y2R Binding (associated) of in hippocampus associated with hippocampus
18) Confidence 0.11 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC3009664 Disease Relevance 0 Pain Relevance 0.18
The interaction is specific for P2Y (12); other purinoceptors such as P2Y (1) and P2Y (13) are spared.
P2Y Binding (interaction) of
19) Confidence 0.05 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852221 Disease Relevance 0 Pain Relevance 0.32
This results in inhibition of the binding of the P2Y (12) agonist 2-methylthio-ADP and the ADP-induced downregulation of adenylyl cyclase.
P2Y Binding (binding) of associated with agonist
20) Confidence 0.05 Published 2005 Journal Semin. Thromb. Hemost. Section Abstract Doc Link 15852221 Disease Relevance 0.21 Pain Relevance 0.35

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