INT126566

Context Info Confidence 0.31 First Reported 2005 Last Reported 2009 Negated 0 Speculated 1 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 2.43 Pain Relevance 0.85

extracellular space (Ifnb1) extracellular region (Ifnb1)

Ifnb1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Multiple sclerosis 71 97.76 Inflammatory mediators 1 91.36 cytokine 2 90.04 imagery 1 82.08 Neuritis 1 76.72 Pain 2 55.92 Paracetamol 1 50.72 methotrexate 1 25.00 Analgesic 1 25.00 depression 6 8.76

Disease Link Frequency Relevance Heat Disease Progression 2 99.68 Recurrence 5 99.54 Syndrome 6 99.20 Demyelinating Disease 72 97.76 Disease 4 94.16 INFLAMMATION 1 91.36 Experimental Autoimmune Neuritis 1 77.68 Influenza Virus Infection 1 66.24 Mental Disorders 9 63.72 Pain 3 55.92

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These agents reduce relapse rates, and IFNbeta-1a is associated with a slowing of disease progression.

IFNbeta Binding (associated) of associated with disease progression and recurrence

1) Confidence 0.31 Published 2007 Journal Curr Med Res Opin Section Abstract Doc Link 17559719 Disease Relevance 0.74 Pain Relevance 0.21

Actually, a multicenter study in Germany (n = 1157) showed that HRQoL was considerably lower in early stages of MS compared with the general population but was improved, with statistically significant results, after treatment initiation with Interferon-beta.49

Interferon-beta Binding (initiation) of associated with multiple sclerosis

2) Confidence 0.09 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778410 Disease Relevance 0.29 Pain Relevance 0.14

Neutralizing antibodies are more likely to occur with interferon-beta1b, but their clinical significance has shown conflicting and confusing results making the utility of measuring neutralizing antibodies uncertain.

interferon-beta1b Spec (likely) Binding (occur) of

3) Confidence 0.09 Published 2005 Journal Expert Rev Neurother Section Abstract Doc Link 15853486 Disease Relevance 0.55 Pain Relevance 0.25

[CSF filtration and interferon-beta for Guillain-Barré syndrome].

interferon-beta Binding (filtration) of associated with syndrome

4) Confidence 0.01 Published 2008 Journal Nippon Rinsho Section Title Doc Link 18540371 Disease Relevance 0.85 Pain Relevance 0.25

General Comments

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