INT126566

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 2.43
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifnb1) extracellular region (Ifnb1)
Ifnb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 71 97.76 Very High Very High Very High
Inflammatory mediators 1 91.36 High High
cytokine 2 90.04 High High
imagery 1 82.08 Quite High
Neuritis 1 76.72 Quite High
Pain 2 55.92 Quite High
Paracetamol 1 50.72 Quite High
methotrexate 1 25.00 Low Low
Analgesic 1 25.00 Low Low
depression 6 8.76 Low Low
Disease Link Frequency Relevance Heat
Disease Progression 2 99.68 Very High Very High Very High
Recurrence 5 99.54 Very High Very High Very High
Syndrome 6 99.20 Very High Very High Very High
Demyelinating Disease 72 97.76 Very High Very High Very High
Disease 4 94.16 High High
INFLAMMATION 1 91.36 High High
Experimental Autoimmune Neuritis 1 77.68 Quite High
Influenza Virus Infection 1 66.24 Quite High
Mental Disorders 9 63.72 Quite High
Pain 3 55.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These agents reduce relapse rates, and IFNbeta-1a is associated with a slowing of disease progression.
IFNbeta Binding (associated) of associated with disease progression and recurrence
1) Confidence 0.31 Published 2007 Journal Curr Med Res Opin Section Abstract Doc Link 17559719 Disease Relevance 0.74 Pain Relevance 0.21
Actually, a multicenter study in Germany (n = 1157) showed that HRQoL was considerably lower in early stages of MS compared with the general population but was improved, with statistically significant results, after treatment initiation with Interferon-beta.49
Interferon-beta Binding (initiation) of associated with multiple sclerosis
2) Confidence 0.09 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778410 Disease Relevance 0.29 Pain Relevance 0.14
Neutralizing antibodies are more likely to occur with interferon-beta1b, but their clinical significance has shown conflicting and confusing results making the utility of measuring neutralizing antibodies uncertain.
interferon-beta1b Spec (likely) Binding (occur) of
3) Confidence 0.09 Published 2005 Journal Expert Rev Neurother Section Abstract Doc Link 15853486 Disease Relevance 0.55 Pain Relevance 0.25
[CSF filtration and interferon-beta for Guillain-Barré syndrome].
interferon-beta Binding (filtration) of associated with syndrome
4) Confidence 0.01 Published 2008 Journal Nippon Rinsho Section Title Doc Link 18540371 Disease Relevance 0.85 Pain Relevance 0.25

General Comments

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