INT126567

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Context Info
Confidence 0.59
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.16
Pain Relevance 3.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 6
neurons 2
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 21 100.00 Very High Very High Very High
Central nervous system 11 100.00 Very High Very High Very High
Nerve growth factor 8 100.00 Very High Very High Very High
antidepressant 58 99.98 Very High Very High Very High
long-term potentiation 14 99.60 Very High Very High Very High
headache 12 99.40 Very High Very High Very High
Glutamate 9 97.04 Very High Very High Very High
Hippocampus 19 96.10 Very High Very High Very High
depression 62 93.44 High High
Kinase C 87 91.28 High High
Disease Link Frequency Relevance Heat
Injury 10 100.00 Very High Very High Very High
Stress 208 99.98 Very High Very High Very High
Headache 5 99.40 Very High Very High Very High
Depressive Disorder 49 99.18 Very High Very High Very High
Apoptosis 133 98.52 Very High Very High Very High
Cognitive Disorder 20 98.28 Very High Very High Very High
Headache Disorders 6 98.08 Very High Very High Very High
Virus Diseases 94 97.64 Very High Very High Very High
Disease 267 97.28 Very High Very High Very High
Infection 22 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased levels of BDNF are necessary for the survival of neurons.
Positive_regulation (necessary) of Positive_regulation (Increased) of BDNF in neurons associated with bdmf
1) Confidence 0.59 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.66 Pain Relevance 0.53
It is well known that several intracellular pathways can mediate ERK phosphorylation in response to neurotrophins or other extracellular signals [47,48].
Positive_regulation (mediate) of Positive_regulation (response) of neurotrophin
2) Confidence 0.49 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1401496 Disease Relevance 0.54 Pain Relevance 0.44
ProNGF levels were also found to be enhanced after CNS injury, together with upregulation of the p75 neurotrophin receptor and increased p75-mediated apoptosis [91].
Positive_regulation (enhanced) of Positive_regulation (upregulation) of neurotrophin associated with injury, central nervous system and apoptosis
3) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.45 Pain Relevance 0.19
Acute stress induces also a significant increase in proBDNF levels and reduction in mature BDNF suggesting altered regulation of proBDNF proteolytic processing.
Positive_regulation (induces) of Positive_regulation (increase) of proBDNF associated with stress
4) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Abstract Doc Link PMC2829032 Disease Relevance 0.79 Pain Relevance 0
In addition, we show that acute stress induces a significant increase in the proBDNF levels and a corresponding reduction in mature BDNF suggesting altered regulation of proBDNF proteolytic processing.
Positive_regulation (induces) of Positive_regulation (increase) of proBDNF associated with stress
5) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.45 Pain Relevance 0
Similarly, in the brain, the mature form consisted in 60% of total BDNF and the proBDNF in 40% of total BDNF (Fig. 9B). 30 min of acute stress had no effects on the total amount of BDNF in the brain but induced a highly significant increase in the proBDNF levels and a corresponding significant reduction in mature BDNF (p < 0.01 vs. control, Fig. 9B).
Neg (no) Positive_regulation (induced) of Positive_regulation (increase) of proBDNF in brain associated with stress
6) Confidence 0.36 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2829032 Disease Relevance 0.10 Pain Relevance 0
The neurotrophic theory of depression postulates that (1) reduced brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) in the hippocampus and associated limbic structures, originating from chronic exposure to stress hormones in susceptible individuals, causes or worsens depressive disorders, and that (2) effective antidepressants contribute to neurotrophic factor upregulation in the dysfunctional limbic structures by restoring normal HPA-axis function (i.e., Antidepressants work to lower stress levels and increase BDNF availability, thereby allowing natural repair mechanisms to correct functional deficits and ultimately reduce symptoms) (Duman and Monteggia, 2006; Pittenger and Duman, 2008).
Positive_regulation (contribute) of Positive_regulation (upregulation) of neurotrophic factor in brain associated with stress, antidepressant, depression, hippocampus and depressive disorder
7) Confidence 0.29 Published 2010 Journal Frontiers in Neuroengineering Section Body Doc Link PMC2901135 Disease Relevance 1.21 Pain Relevance 0.53
These findings suggest the potential involvement of nerve growth factor-mediated upregulation of brain-derived neurotrophic factor in persistent head pain.
Positive_regulation (involvement) of Positive_regulation (upregulation) of brain-derived neurotrophic factor in brain associated with nerve growth factor and headache
8) Confidence 0.04 Published 2004 Journal Expert Rev Neurother Section Abstract Doc Link 15853622 Disease Relevance 0.95 Pain Relevance 1.38

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