INT126572

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.98
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (SYK) cytosol (SYK) plasma membrane (SYK)
cytoplasm (SYK)
SYK (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 98.84 Very High Very High Very High
antagonist 5 93.68 High High
chemokine 8 88.56 High High
Inflammation 24 88.40 High High
pruritus 1 75.04 Quite High
headache 1 72.32 Quite High
Pain 1 70.72 Quite High
cINOD 1 65.40 Quite High
Onset of action 1 65.04 Quite High
corticosteroid 9 33.20 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 3 98.58 Very High Very High Very High
Alzheimer's Dementia 3 97.40 Very High Very High Very High
INFLAMMATION 20 88.40 High High
Hypersensitivity 28 87.88 High High
Asthma 50 83.08 Quite High
Rhinitis 10 82.24 Quite High
Cognitive Disorder 2 80.92 Quite High
Neurodegenerative Disease 2 79.60 Quite High
Injury 2 77.76 Quite High
Sneezing 1 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microglial activation might involve beta-amyloid binding and activation of cell surface immune and adhesion molecules such as CD45, CD40, CD36 and integrins, with the subsequent recruitment of Src family tyrosine kinases such as Fyn, Lyn and Syk kinases.
Positive_regulation (recruitment) of Syk associated with alzheimer's dementia and adhesions
1) Confidence 0.67 Published 2005 Journal Curr Drug Targets Inflamm Allergy Section Abstract Doc Link 15853747 Disease Relevance 1.28 Pain Relevance 0.38
Additionally, Western blot demonstrated that Syk-positive PTCLs show tyrosine (525/526) phosphorylation, which is known to be required for Syk activation.
Positive_regulation (activation) of Syk
2) Confidence 0.22 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0.04
Upon cross-linking of IgE bound high affinity IgE receptors, Syk kinase is activated and leads to degranulation, cytokine synthesis and leukotriene synthesis.
Positive_regulation (activated) of Syk kinase associated with cytokine
3) Confidence 0.08 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 1.03 Pain Relevance 0.42

General Comments

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