INT12658

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2010
Negated 6
Speculated 5
Reported most in Abstract
Documents 9
Total Number 15
Disease Relevance 2.44
Pain Relevance 14.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
afferent neurons 4
CPu 3
brain 2
dorsal root ganglia 2
nervous system 2
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 726 100.00 Very High Very High Very High
Morphine 279 100.00 Very High Very High Very High
mu opioid receptor 125 100.00 Very High Very High Very High
MU agonist 98 100.00 Very High Very High Very High
Inflammation 29 100.00 Very High Very High Very High
Thalamus 6 100.00 Very High Very High Very High
Arthritis 3 98.48 Very High Very High Very High
agonist 50 97.96 Very High Very High Very High
Opioid 139 97.12 Very High Very High Very High
Enkephalin 8 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Targeted Disruption 7 99.96 Very High Very High Very High
Arthritis 3 98.48 Very High Very High Very High
Anxiety Disorder 5 75.00 Quite High
Inflammatory Pain 3 75.00 Quite High
Nociception 4 70.12 Quite High
Pain 7 68.52 Quite High
Adult Respiratory Distress Syndrome 1 54.20 Quite High
Sepsis 1 53.32 Quite High
Increased Venous Pressure Under Development 1 52.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No effect of chronic nimodipine alone on mu-opioid receptor binding was observed.
Neg (No) Regulation (effect) of mu-opioid receptor Binding (binding) of associated with opioid receptor
1) Confidence 0.57 Published 2000 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 10880689 Disease Relevance 0 Pain Relevance 1.39
Truncation of the mu receptor by removal of its carboxyl terminus at Glu341 did not affect the ability of the fentanyl analogs to bind to and activate the mu receptor nor did it prevent the fentanyl analogs from desensitizing the receptor.
Neg (not) Regulation (affect) of mu receptor Neg (nor) Binding (bind) of
2) Confidence 0.45 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.07 Pain Relevance 0.67
In contrast, morphine administration did not alter the [(3)H]muscimol binding in mu-opioid receptor knockout mice.
Neg (not) Regulation (alter) of mu-opioid receptor Binding (binding) of associated with targeted disruption, opioid receptor and morphine
3) Confidence 0.27 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 11927374 Disease Relevance 0.48 Pain Relevance 1.15
In vivo, rafts association of MOR in CPu and thalamus was not affected significantly in rats implanted with two 75-mg morphine pellets for 72 h.
Neg (not) Regulation (affected) of MOR Binding (association) of in CPu associated with mu opioid receptor, thalamus and morphine
4) Confidence 0.23 Published 2007 Journal Brain Res. Section Abstract Doc Link 17980352 Disease Relevance 0 Pain Relevance 0.93
These findings show that inflammation causes changes in MOP receptor binding and G protein coupling after DAMGO stimulation selectively in primary afferent neurons but did not cause any adaptive changes of MOP receptor in HT or SC.
Regulation (changes) of MOP receptor Binding (binding) of in afferent neurons associated with inflammation and spinal cord
5) Confidence 0.20 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14593084 Disease Relevance 0.48 Pain Relevance 0.80
To examine the effect of opioid agonists on the MOR/GPR177 interaction in greater detail, we used coimmunoprecipitation to investigate whether opioid treatment promotes MOR/GPR177 complex formation.
Spec (examine) Regulation (effect) of MOR Binding (interaction) of associated with mu agonist, opioid receptor and opioid
6) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.48
Our analysis of the effect of opioid agonists on MOR/GPR177 complex formation, together with the Wnt secretion experiments, indicate that the MOR/GPR177 interaction is likely to be of importance for understanding the changes that occur in brain after chronic opioid use.
Regulation (effect) of MOR Binding (formation) of in brain associated with mu agonist, opioid receptor and opioid
7) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 0.66
DAMGO, on the other hand, results in MOR internalization, thus leading to an increased association between the MOR and GPR177 within the cytosol.


Regulation (results) of MOR Binding (internalization) of associated with opioid receptor
8) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.10
To investigate the effect of opioid agonists on MOR/GPR177 complex formation, we first used confocal laser microscopy to examine the distribution of MOR and GPR177 polypeptides in 293-MOR cells treated with 10 ?
Spec (investigate) Regulation (effect) of MOR Binding (formation) of associated with mu agonist and opioid receptor
9) Confidence 0.15 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2841195 Disease Relevance 0 Pain Relevance 1.09
We investigated the influence of this regulatory process on the capacity of morphine to promote desensitization and its association with MOR recycling in the mature nervous system.
Spec (investigated) Regulation (influence) of MOR Binding (association) of in nervous system associated with morphine
10) Confidence 0.13 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC1947952 Disease Relevance 0 Pain Relevance 1.35
In vivo, rafts association of MOR in CPu and thalamus was not affected significantly in rats implanted with two 75-mg morphine pellets for 72 h.
Neg (not) Regulation (affected) of MOR in thalamus Binding (association) of in CPu associated with mu opioid receptor, thalamus and morphine
11) Confidence 0.08 Published 2007 Journal Brain Res. Section Abstract Doc Link 17980352 Disease Relevance 0 Pain Relevance 0.93
Unlike effects observed in the cyclic pentapeptide series, the mu receptor binding affinities of the cyclic tetrapeptides are not dramatically influenced by substitution of Pen for Cys at residue 2.
Neg (not) Regulation (influenced) of mu receptor Binding (affinities) of
12) Confidence 0.06 Published 1991 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1651290 Disease Relevance 0 Pain Relevance 0.33
The present study investigated the effects of inflammation on MOR binding and G-protein coupling of full versus partial MOR agonists in dorsal root ganglia (DRG) of primary afferent neurons.
Spec (investigated) Regulation (effects) of MOR Binding (binding) of in dorsal root ganglia associated with inflammation, agonist and mu opioid receptor
13) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12869624 Disease Relevance 0.51 Pain Relevance 1.19
These findings show that inflammation causes changes in MOR binding and G-protein coupling in primary afferent neurons.
Regulation (changes) of MOR Binding (binding) of in afferent neurons associated with inflammation and mu opioid receptor
14) Confidence 0.01 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12869624 Disease Relevance 0.63 Pain Relevance 1.26
Because activation of the sphingosine 1-phosphate receptor, S1P(3), is key to a number of barrier-disruptive responses, we examined the role of this receptor in the permeability response to mOP-R ligation.
Spec (examined) Regulation (role) of mOP-R Spec (examined) Binding (ligation) of
15) Confidence 0.00 Published 2007 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 17395891 Disease Relevance 0.26 Pain Relevance 0.63

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