INT126581

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.59
Pain Relevance 2.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

anatomical structure formation involved in morphogenesis (Gli3) intracellular (Gli3) cilium (Gli3)
DNA binding (Gli3) cytoplasm (Gli3) cytosol (Gli3)
Anatomy Link Frequency
Schwann cells 1
Gli3 (Mus musculus)
Pain Link Frequency Relevance Heat
Painful diabetic neuropathy 27 100.00 Very High Very High Very High
diabetic neuropathy 11 100.00 Very High Very High Very High
Dynorphin 20 99.76 Very High Very High Very High
Kappa opioid receptor 4 98.32 Very High Very High Very High
allodynia 39 94.80 High High
Spinal cord 6 92.80 High High
Hyperalgesia 8 91.00 High High
Thermal hyperalgesia 1 88.96 High High
substance P 9 85.84 High High
Nerve growth factor 45 80.88 Quite High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 43 100.00 Very High Very High Very High
Diabetes Mellitus 47 99.84 Very High Very High Very High
Neuropathic Pain 48 94.80 High High
Hyperalgesia 10 91.00 High High
Genomic Instability 1 42.24 Quite Low
Premature Aging 1 41.20 Quite Low
Pain 15 31.12 Quite Low
INFLAMMATION 23 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Nervous System Injury 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Future studies should address the distinct roles of central versus peripheral p38 activation in PDN of type 2 diabetes.
Positive_regulation (activation) of PDN associated with painful diabetic neuropathy and diabetes mellitus
1) Confidence 0.35 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.82 Pain Relevance 1.12
Furthermore, beta-cells treated with high glucose (20 mM) show increased cytoplasmic calcium (approximately 200 nM), which eliminates DREAM's interaction with the DRE, causing increased PDN promoter activity.
Positive_regulation (causing) of PDN
2) Confidence 0.05 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.24
In vitro studies in human endothelial and Schwann cells showed early accumulation of poly(ADP-ribosyl)ated proteins (Western blot analysis) in response to high glucose, thus suggesting the importance of PARP activation in human PDN.
Positive_regulation (activation) of PDN in Schwann cells associated with diabetic neuropathy
3) Confidence 0.03 Published 2005 Journal Diabetes Section Abstract Doc Link 15855340 Disease Relevance 0.77 Pain Relevance 0.49
As PDN is cleaved into dynorphin peptides, which stimulate kappa-opioid receptors expressed predominantly in alpha-cells of the islet, we determined the role of dynorphin A-(1-17) in glucagon secretion from the alpha-cell.
Positive_regulation (cleaved) of PDN associated with dynorphin and kappa opioid receptor
4) Confidence 0.03 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.25
Furthermore, beta-cells treated with high glucose (20 mM) show increased cytoplasmic calcium (approximately 200 nM), which eliminates DREAM's interaction with the DRE, causing increased PDN promoter activity.
Positive_regulation (increased) of PDN
5) Confidence 0.03 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.24
Under low glucose conditions, with intracellular calcium concentrations of <100 nM, DREAM(-/-) islets had an 80% increase in PDN message compared with controls.
Positive_regulation (increase) of PDN
6) Confidence 0.03 Published 2006 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 16621893 Disease Relevance 0 Pain Relevance 0.14

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