INT126583

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Context Info
Confidence 0.68
First Reported 2003
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 50
Total Number 50
Disease Relevance 41.44
Pain Relevance 7.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 12
poly 5
lung 5
endothelium 3
apoptotic cell 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 15 100.00 Very High Very High Very High
Paracetamol 18 99.98 Very High Very High Very High
diabetic neuropathy 11 99.60 Very High Very High Very High
aspirin 23 99.50 Very High Very High Very High
qutenza 21 99.12 Very High Very High Very High
Inflammation 291 98.00 Very High Very High Very High
Inflammatory mediators 7 97.56 Very High Very High Very High
depression 7 97.52 Very High Very High Very High
cytokine 66 96.64 Very High Very High Very High
Angina 9 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 854 100.00 Very High Very High Very High
Diabetes Mellitus 272 99.96 Very High Very High Very High
Cancer 360 99.84 Very High Very High Very High
Lung Injury 496 99.64 Very High Very High Very High
Diabetic Neuropathy 7 99.60 Very High Very High Very High
Colon Cancer 12 99.48 Very High Very High Very High
Renal Failure 19 99.44 Very High Very High Very High
Acute Renal Failure 168 99.32 Very High Very High Very High
Death 317 99.04 Very High Very High Very High
Adult Respiratory Distress Syndrome 90 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation and overexpression of PARP-1 in circulating mononuclear cells promote TNF-alpha and IL-6 expression in patients with unstable angina.
Positive_regulation (Activation) of PARP in mononuclear cells associated with angina
1) Confidence 0.68 Published 2008 Journal Arch. Med. Res. Section Title Doc Link 18996291 Disease Relevance 0.37 Pain Relevance 0.50
In vitro studies in human endothelial and Schwann cells showed early accumulation of poly(ADP-ribosyl)ated proteins (Western blot analysis) in response to high glucose, thus suggesting the importance of PARP activation in human PDN.
Positive_regulation (activation) of PARP in Schwann cells associated with diabetic neuropathy
2) Confidence 0.62 Published 2005 Journal Diabetes Section Abstract Doc Link 15855340 Disease Relevance 0.77 Pain Relevance 0.49
Indeed, the PARP pathway is activated both in VILI and ARF [5,15-18].
Positive_regulation (activated) of PARP associated with lung injury and acute renal failure
3) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 1.32 Pain Relevance 0.07
We tested the hypothesis that renal blood flow and endothelial, functional and tissue changes in the kidney of rats with LPS-induced lung injury aggravated by MV, is caused, in part, by activation of PARP by peroxynitrite.
Positive_regulation (activation) of PARP in kidney associated with lung injury
4) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.83 Pain Relevance 0.04
To our knowledge, renal mechanisms involved in VILI-associated ARF and in particular related to the activation of PARP by peroxynitrite have not been studied before.
Positive_regulation (activation) of PARP associated with lung injury and acute renal failure
5) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.82 Pain Relevance 0
Oxygen and nitrogen-derived reactive species, such as peroxynitrite, induce oxidative DNA damage and consequent activation of the nuclear enzyme PARP.
Positive_regulation (activation) of PARP
6) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 1.13 Pain Relevance 0.07
According to Western blot analysis, treatment with AAP increased the level of poly(ADP-ribose) polymerase (PARP) fragments in cells compared with that in control cells; however, caspase-3, a critical signaling molecule in apoptosis, was not activated after AAP overdose.
Positive_regulation (increased) of PARP in poly associated with paracetamol, apoptosis and overdose
7) Confidence 0.51 Published 2007 Journal Toxicology Section Abstract Doc Link 17169476 Disease Relevance 0.85 Pain Relevance 0.84
These results are in agreement with previous reports in that tolfenamic acid induces PARP cleavage in colorectal cancer cells [19] and pancreatic cancer cells [4].
Positive_regulation (induces) of PARP in cleavage associated with pancreatic cancer and colon cancer
8) Confidence 0.50 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901767 Disease Relevance 0.82 Pain Relevance 0.07
In diabetes, activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an important effector of oxidative-nitrosative injury, which contributes to the development of experimental diabetic peripheral neuropathy (DPN).
Positive_regulation (activation) of PARP in poly associated with diabetes mellitus, diabetic neuropathy, injury and peripheral neuropathy
9) Confidence 0.50 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17021258 Disease Relevance 0.82 Pain Relevance 0.12
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


Positive_regulation (promotes) of PARP in MNCs
10) Confidence 0.49 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
SUL and/or IND significantly increased annexin V-positive cells, cleaved poly(ADP-ribose) polymerase (PARP) and caspase-3.
Positive_regulation (increased) of PARP in poly
11) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.68 Pain Relevance 0.67
ASA and NaS at 1 mM did not induce PARP cleavage or caspase-3 and at 5 mM, ASA but not NaS increased apoptosis.
Neg (not) Positive_regulation (induce) of PARP in cleavage associated with aspirin and apoptosis
12) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.66
Our current study suggests that hypoperfusion, impaired endothelial vasodilation, and associated functional and tissue changes in the kidney of rats with LPS-induced lung injury aggravated by MV, are caused, in part, by activation of PARP by peroxynitrite.
Positive_regulation (activation) of PARP in lung associated with lung injury and increased venous pressure under development
13) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.61 Pain Relevance 0.05
We demonstrated that inhibition of PARP activation by peroxynitrite attenuates VILI and renal hypoperfusion and dysfunction, by maintaining endothelium-dependent vasodilation and decreasing inflammation and tissue injury.


Positive_regulation (activation) of PARP in endothelium associated with lung injury, inflammation, injury and increased venous pressure under development
14) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.85 Pain Relevance 0.05
Second, taking into account the possible gender differences with respect to PARP activation found in animal models of stroke and LPS-induced inflammation, the results discussed previously might be applicable only to males [50-52].
Positive_regulation (activation) of PARP associated with inflammation and stroke
15) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.73 Pain Relevance 0.11
Peroxynitrite formation and PARP activation in lungs of animals with VILI have been demonstrated before [5,16,27].
Positive_regulation (activation) of PARP in lungs associated with lung injury
16) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.85 Pain Relevance 0.03
In the current study we therefore tested the hypothesis that renal blood flow and endothelial, functional and tissue changes in the kidney of rats with lipopolysaccharide (LPS)-induced lung injury aggravated by MV, is caused, in part, by activation of PARP by peroxynitrite.


Positive_regulation (activation) of PARP in lung associated with lung injury
17) Confidence 0.37 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887157 Disease Relevance 0.68 Pain Relevance 0.08
In conclusion, our data suggest that inhibition of PARP activation by peroxynitrite attenuates VILI and renal hypoperfusion and dysfunction, by maintaining endothelium-dependent vasodilation and decreasing inflammation and tissue injury, in the rat kidney during LPS-induced lung injury aggravated by MV.


Positive_regulation (activation) of PARP in lung associated with lung injury, inflammation, injury and increased venous pressure under development
18) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 1.29 Pain Relevance 0.09
The peroxynitrite-induced PARP activation is involved in renal hypoperfusion, impaired endothelium-dependent vasodilation and resultant dysfunction, and injury, in a model of lung injury.



Positive_regulation (activation) of PARP in endothelium associated with lung injury, injury and increased venous pressure under development
19) Confidence 0.37 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887157 Disease Relevance 0.90 Pain Relevance 0
The compound thus blocks peroxynitrite and thereby reduces PARP activation [24-26].
Positive_regulation (activation) of PARP
20) Confidence 0.37 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 0.85 Pain Relevance 0.03

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