INT126584

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
Schwann cells 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diabetic neuropathy 7 99.60 Very High Very High Very High
Hyperalgesia 2 91.76 High High
Thermal hyperalgesia 1 89.72 High High
agonist 1 53.68 Quite High
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 7 99.60 Very High Very High Very High
Hyperalgesia 3 91.76 High High
Diabetes Mellitus 3 77.40 Quite High
Genomic Instability 1 43.00 Quite Low
Premature Aging 1 41.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies in human endothelial and Schwann cells showed early accumulation of poly(ADP-ribosyl)ated proteins (Western blot analysis) in response to high glucose, thus suggesting the importance of PARP activation in human PDN.
Regulation (importance) of Positive_regulation (activation) of PARP in Schwann cells associated with diabetic neuropathy
1) Confidence 0.24 Published 2005 Journal Diabetes Section Abstract Doc Link 15855340 Disease Relevance 0.78 Pain Relevance 0.49

General Comments

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