INT126585

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.84
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 2
Schwann cells 2
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
diabetic neuropathy 7 99.60 Very High Very High Very High
Hyperalgesia 2 91.76 High High
Thermal hyperalgesia 1 89.72 High High
Inflammatory response 3 80.08 Quite High
agonist 1 53.68 Quite High
Kinase C 21 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 7 99.60 Very High Very High Very High
Apoptosis 51 98.76 Very High Very High Very High
Stress 18 98.44 Very High Very High Very High
Death 12 98.16 Very High Very High Very High
Injury 11 97.84 Very High Very High Very High
Acute Renal Failure 12 96.76 Very High Very High Very High
Lung Injury 35 96.44 Very High Very High Very High
Hyperalgesia 3 91.76 High High
Body Weight 28 84.32 Quite High
INFLAMMATION 8 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Oxygen and nitrogen-derived reactive species, such as peroxynitrite, induce oxidative DNA damage and consequent activation of the nuclear enzyme PARP.
Positive_regulation (induce) of Positive_regulation (activation) of PARP
1) Confidence 0.55 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 1.16 Pain Relevance 0.07
In vitro studies in human endothelial and Schwann cells showed early accumulation of poly(ADP-ribosyl)ated proteins (Western blot analysis) in response to high glucose, thus suggesting the importance of PARP activation in human PDN.
Positive_regulation (importance) of Positive_regulation (activation) of PARP in Schwann cells associated with diabetic neuropathy
2) Confidence 0.45 Published 2005 Journal Diabetes Section Abstract Doc Link 15855340 Disease Relevance 0.78 Pain Relevance 0.49
As caused mitochondrial injury by increased oxidative stress and reciprocal regulation of Bcl-2, Bcl-xL/Bad, Bax, Bim in association with increased level of Apaf-1, activation of caspase 9/3, cleavage of PARP protein and ultimately led to apoptotic cell death.
Positive_regulation (increased) of Positive_regulation (activation) of PARP in cleavage associated with stress, injury, apoptosis and death
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.90 Pain Relevance 0

General Comments

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