INT126586

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 4.96
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
MNCs 5
Poly 1
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 41 95.84 Very High Very High Very High
agonist 1 94.84 High High
diabetic neuropathy 7 92.96 High High
Inflammatory response 8 82.64 Quite High
Angina 20 50.00 Quite Low
Hyperalgesia 2 26.56 Quite Low
Thermal hyperalgesia 1 25.00 Low Low
addiction 30 5.00 Very Low Very Low Very Low
cytokine 13 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Genomic Instability 45 97.24 Very High Very High Very High
Apoptosis 211 96.28 Very High Very High Very High
Premature Aging 1 96.20 Very High Very High Very High
INFLAMMATION 47 95.84 Very High Very High Very High
Death 58 95.28 Very High Very High Very High
Diabetic Neuropathy 7 92.96 High High
Squamous Cell Neoplasms 8 92.92 High High
Malignant Neoplastic Disease 17 92.04 High High
Keratosis 16 91.52 High High
Sprains And Strains 3 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study evaluated potential synergistic interactions between low doses of the potent and specific PARP inhibitor 1,5-isoquinolinediol (ISO) and one of two vasodilators, the ACE inhibitor lisinopril (LIS) and the beta2-adrenoceptor agonist salbutamol (SAL) in the model of early PDN.
PARP Binding (interactions) of associated with diabetic neuropathy and agonist
1) Confidence 0.43 Published 2005 Journal Diabetes Section Abstract Doc Link 15855340 Disease Relevance 0.69 Pain Relevance 0.22
Addition of recombinant human PARP-1 protein to nuclear extracts of MNCs significantly increased the DNA binding activity of NF-kappaB.
PARP-1 protein Binding (binding) of in MNCs
2) Confidence 0.37 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.06 Pain Relevance 0
MNCs from healthy subjects were cultured to investigate the direct effects of PARP-1 on NF-kappaB DNA binding activity and the expression of TNF-alpha and IL-6.
PARP Binding (binding) of in MNCs
3) Confidence 0.35 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.08 Pain Relevance 0
Circulating MNCs were analyzed for PARP activity, PARP-1 expression and NF-kappaB DNA binding activity.
PARP Binding (activity) of in MNCs
4) Confidence 0.35 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.09 Pain Relevance 0
Circulating MNCs were analyzed for PARP activity, PARP-1 expression and NF-kappaB DNA binding activity.
PARP Binding (binding) of in MNCs
5) Confidence 0.35 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0.09 Pain Relevance 0
Overexpressed PARP-1 promotes PARP-1/NF-kappaB/DNA complex formation, thereby enhancing the expression of TNF-alpha and IL-6 in circulating MNCs of UA patients.


PARP Binding (formation) of in MNCs
6) Confidence 0.35 Published 2008 Journal Arch. Med. Res. Section Body Doc Link 18996291 Disease Relevance 0 Pain Relevance 0
PARP-1 has been reported to frequently associate with transcriptionally active regions of chromatin [134, 135].
PARP-1 Binding (associate) of
7) Confidence 0.34 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.92 Pain Relevance 0.07
While PARP-1 inhibition could impair its role in DNA repair, PARP-1 overactivation is detrimental to the cells by depleting its substrate NAD+, which leads to cellular energy crisis and necrotic cell death.
PARP-1 Binding (overactivation) of associated with death
8) Confidence 0.27 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 1.37 Pain Relevance 0.09
PARP-1 inhibition with nicotinamide and benzamides was also shown to inhibit NF-?
PARP-1 Neg (inhibition) Binding (inhibition) of
9) Confidence 0.27 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.95 Pain Relevance 0.15
PARP-1 is a nuclear enzyme which detects DNA damage, binds to DNA single or double strand breaks, and then uses NAD+ as a substrate to form nicotinamide and ADP-ribose.
PARP-1 Binding (binds) of
10) Confidence 0.26 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2915624 Disease Relevance 0.22 Pain Relevance 0
The membrane was then probed with primary antibodies to Bcl-2, Bax, Bid, cytochrome c, caspase-3, -8, -9, PARP and ?
PARP Binding (antibodies) of
11) Confidence 0.18 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2987898 Disease Relevance 0 Pain Relevance 0
Membranes were blocked with 5% milk in TBS containing 0.1% Tween 20, and incubated with antibodies specific for caspase 8 (Abcam), caspase 9, PARP, Snail (Cell Signaling Technology), pGSK3?
PARP Binding (specific) of
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.26 Pain Relevance 0
The same study also indicated that PARP-1 can interact with the gene regulatory sequences by binding to promoter-localized cruciforms.
PARP-1 Binding (interact) of
13) Confidence 0.10 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1524902 Disease Relevance 0.08 Pain Relevance 0
The same study also indicated that PARP-1 can interact with the gene regulatory sequences by binding to promoter-localized cruciforms.
PARP-1 Binding (binding) of
14) Confidence 0.10 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1524902 Disease Relevance 0.08 Pain Relevance 0
Most recently Potaman and colleagues have reported (65) specific binding of Poly(ADP-ribose) Polymerase-1 (PARP-1) to cruciform hairpins.
PARP-1 Binding (binding) of in Poly
15) Confidence 0.10 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1524902 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox