INT126598

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.05
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (BSG, OPRK1) mitochondrion (BSG) small molecule metabolic process (BSG)
signal transducer activity (OPRK1)
BSG (Homo sapiens)
OPRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 2 100.00 Very High Very High Very High
Dynorphin 6 97.52 Very High Very High Very High
mu opioid receptor 4 96.20 Very High Very High Very High
Kappa opioid receptor 6 93.96 High High
Analgesic 3 58.44 Quite High
MU agonist 1 54.08 Quite High
analgesia 1 46.68 Quite Low
Central nervous system 1 44.56 Quite Low
Disease Link Frequency Relevance Heat
Psychosis 2 51.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These chimeras may be useful in identifying novel kappa receptor agonists that bind to the second extracellular loop of the receptor and share the desirable therapeutic profile of dynorphin A.
extracellular Binding (bind) of kappa receptor associated with dynorphin and agonist
1) Confidence 0.01 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15857313 Disease Relevance 0.05 Pain Relevance 0.72

General Comments

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