INT126598

Context Info Confidence 0.01 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.05 Pain Relevance 0.72

plasma membrane (BSG, OPRK1) mitochondrion (BSG) small molecule metabolic process (BSG) signal transducer activity (OPRK1)

BSG (Homo sapiens) OPRK1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 2 100.00 Dynorphin 6 97.52 mu opioid receptor 4 96.20 Kappa opioid receptor 6 93.96 Analgesic 3 58.44 MU agonist 1 54.08 analgesia 1 46.68 Central nervous system 1 44.56

Disease Link Frequency Relevance Heat Psychosis 2 51.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These chimeras may be useful in identifying novel kappa receptor agonists that bind to the second extracellular loop of the receptor and share the desirable therapeutic profile of dynorphin A.

extracellular Binding (bind) of kappa receptor associated with dynorphin and agonist

1) Confidence 0.01 Published 2005 Journal Curr Top Med Chem Section Abstract Doc Link 15857313 Disease Relevance 0.05 Pain Relevance 0.72

General Comments

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