INT126608

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 0.46
Pain Relevance 4.38

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cytosol (Stat5a) signal transduction (Stat5a) nucleolus (Stat5a)
nucleus (Stat5a) DNA binding (Stat5a) cytoplasm (Stat5a)
Anatomy Link Frequency
tail 2
proximal 1
brain 1
Stat5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 56 99.44 Very High Very High Very High
Morphine 13 99.40 Very High Very High Very High
antagonist 1 97.20 Very High Very High Very High
narcan 1 96.76 Very High Very High Very High
Opioid 6 91.84 High High
Enkephalin 6 87.92 High High
MU agonist 6 84.12 Quite High
cytokine 3 81.92 Quite High
mu opioid receptor 1 49.68 Quite Low
Disease Link Frequency Relevance Heat
Bordatella Infection 6 87.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutation of the Y336 to alanine does not prevent STAT5A binding, whereas deletion of the entire putative STAT5A binding site YXXL abolishes STAT5A interaction to the carboxyl-terminal tail of the micro-opioid receptor.
STAT5A Binding (binding) of in tail associated with opioid receptor
1) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.08 Pain Relevance 0.64
Co-immunoprecipitation and pull-down experiments using a GST-carboxyl-terminal tail of the micro-opioid receptor and rat brain, or COS-7 cell cytosolic extracts, demonstrate the direct binding of STAT5A to this region.
STAT5A Binding (binding) of in brain associated with opioid receptor
2) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.08 Pain Relevance 0.65
All three opioid receptor subtypes -micro, delta and kappa- share the conserved motif YXXL (amino-acids 336-339 for the micro-opioid receptor), known to be critical for STAT5A/5B binding.
STAT5A Binding (binding) of associated with opioid receptor
3) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.09 Pain Relevance 0.67
Mutation of the Y336 to alanine does not prevent STAT5A binding, whereas deletion of the entire putative STAT5A binding site YXXL abolishes STAT5A interaction to the carboxyl-terminal tail of the micro-opioid receptor.
STAT5A Binding (interaction) of in tail associated with opioid receptor
4) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.07 Pain Relevance 0.62
STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor.
STAT5A Binding (interacts) of associated with opioid receptor
5) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Title Doc Link 15857395 Disease Relevance 0.07 Pain Relevance 0.55
Collectively, our results demonstrate the association of STAT5A with the micro-opioid receptor and reveal novel signalling pathways in the regulation of transcription by the micro-opioid receptor.
STAT5A Binding (association) of associated with opioid receptor
6) Confidence 0.37 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.07 Pain Relevance 0.60
The data from EMSA-superEMSA and ChIP-qPCR further confirmed that morphine was capable of promoting the binding of STAT5a to its elements (proximal and distal), and this was abolished by the antagonist naloxone.
STAT5a Binding (binding) of in proximal associated with antagonist, narcan and morphine
7) Confidence 0.24 Published 2009 Journal Biochem. Pharmacol. Section Abstract Doc Link 19426693 Disease Relevance 0 Pain Relevance 0.65

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