INT126626

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 4.43
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Rhoa) mitochondrion (Rhoa) cell morphogenesis (Rhoa)
intracellular (Rhoa) GTPase activity (Rhoa) cytoplasm (Rhoa)
Anatomy Link Frequency
smooth muscle 2
neurons 1
smooth muscle cells 1
Rhoa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 8 99.28 Very High Very High Very High
Neuritis 8 98.20 Very High Very High Very High
fluoxetine 8 97.80 Very High Very High Very High
agonist 4 97.12 Very High Very High Very High
Peripheral nervous system 1 91.04 High High
Inflammation 3 75.00 Quite High
addiction 12 72.60 Quite High
nMDA receptor 31 68.40 Quite High
depression 14 53.84 Quite High
Dopamine 1 42.96 Quite Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 222 99.84 Very High Very High Very High
Diabetes Mellitus 85 99.56 Very High Very High Very High
Experimental Autoimmune Neuritis 8 98.20 Very High Very High Very High
Apoptosis 3 97.32 Very High Very High Very High
Increased Venous Pressure Under Development 51 96.40 Very High Very High Very High
Targeted Disruption 2 95.44 Very High Very High Very High
Syndrome 1 94.64 High High
Hepatocellular Cancer 16 89.08 High High
Cardiovascular Disease 36 85.36 High High
Hypersensitivity 5 77.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we analyze the mechanisms of RhoA regulation by serotonin (5-HT) in arterial smooth muscle. 5-HT (0.1-10 microM) induced activation of RhoA followed by RhoA depletion at 24-72 h.
Positive_regulation (activation) of RhoA in smooth muscle associated with serotonin
1) Confidence 0.69 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.23
Stimulation of the RhoA/Rho-kinase (ROK) signaling represents a key step in the maintenance of agonist-induced contraction of smooth muscle.
Positive_regulation (Stimulation) of RhoA in smooth muscle associated with agonist
2) Confidence 0.55 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.05
A significant accumulation of RhoA+ cells was observed on Day 12, with a maximum around Day 15, correlating to the clinical severity of EAN.
Positive_regulation (accumulation) of RhoA associated with neuritis
3) Confidence 0.50 Published 2007 Journal J. Cell. Mol. Med. Section Abstract Doc Link 17367505 Disease Relevance 0.77 Pain Relevance 0.73
Transamidation of RhoA leads to RhoA activation and enhanced proteasomal degradation, which in turn is responsible for Akt activation and contraction inhibition.
Positive_regulation (activation) of RhoA
4) Confidence 0.50 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.17
Transglutaminase-dependent RhoA activation and depletion by serotonin in vascular smooth muscle cells.
Positive_regulation (activation) of RhoA in smooth muscle cells associated with serotonin
5) Confidence 0.46 Published 2007 Journal J. Biol. Chem. Section Title Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.24
This association was calcium-dependent and inhibited by fluoxetine and monodansylcadaverin. 5-HT promotes the association of RhoA with the E3 ubiquitin ligase Smurf1, and 5-HT-induced RhoA depletion was inhibited by the proteasome inhibitor MG132 and the RhoA inhibitor Tat-C3.
Positive_regulation (induced) of RhoA associated with fluoxetine
6) Confidence 0.46 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.26
The first clues for a possible involvement of RhoA in this regulation came from LPA signaling that is known to activate RhoA by the trimeric G protein subfamily member G12/13 [31], [32].
Positive_regulation (activate) of RhoA
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
A more recent study suggested that diabetic-associated ED due to upregulation of the penile RhoA/Rho-kinase pathway enhances PTEN/Akt activity leading to corporal apoptosis [91].
Positive_regulation (upregulation) of RhoA associated with erectile dysfunction, diabetes mellitus and apoptosis
8) Confidence 0.25 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 1.24 Pain Relevance 0
A mechanism for diabetes-induced erectile dysfunction was demonstrated in which upregulated RhoA/Rho-kinase levels were found in cavernosal tissue of streptozotocin-induced diabetic rats.
Positive_regulation (upregulated) of RhoA associated with erectile dysfunction and diabetes mellitus
9) Confidence 0.25 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.80 Pain Relevance 0
Concomitantly, activated RhoA may favor peroxisome association with the actin cytoskeleton possibly by recruiting Rho kinase (ROCKII).
Positive_regulation (activated) of RhoA
10) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0 Pain Relevance 0
Most of the activated cytosolic RhoA translocates to cellular membranes leading to saturation of RhoA binding sites and terminating microtubule-peroxisome interactions.
Positive_regulation (activated) of RhoA
11) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.05 Pain Relevance 0
By closer examination of the RhoA topology, it appeared that activated RhoA concentrated at distinct sites on the peroxisomal membrane rather than exhibiting a continuous staining pattern (Fig. 6F and inset).
Positive_regulation (activated) of RhoA
12) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975642 Disease Relevance 0.09 Pain Relevance 0.04
These compounds also have the ability to block the formation of isoprenoid intermediates required for RhoA activity [92].
Positive_regulation (required) of RhoA
13) Confidence 0.17 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 1.12 Pain Relevance 0
In Abl and Abl-related gene (Arg) double-knock out mice, the extent of dendritic branching in substantially reduced [20] and treatment of developing cultured neurons with the Abl inhibitor, STI571, decreases the complexity of neuronal dendritic branching via an increase in RhoA activity [21] and possible activation of Rho-associated kinase (ROCK) [22-24].
Spec (possible) Positive_regulation (activation) of RhoA in neurons associated with targeted disruption
14) Confidence 0.14 Published 2008 Journal Mol Brain Section Body Doc Link PMC2651131 Disease Relevance 0.20 Pain Relevance 0.17
However, the vascular effects of weak TP-receptor stimulation, like those applied in the present study, are primarily induced by the G12/13-mediated activation of the small G protein RhoA and Rho-kinase (Németh and Benyó, unpublished observations), the main signaling pathway of calcium-sensitization.
Positive_regulation (activation) of protein RhoA
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.17 Pain Relevance 0

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