INT126627

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 3.33
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rock2) cytoskeleton (Rock2) nucleus (Rock2)
kinase activity (Rock2) microtubule organizing center (Rock2) cytoplasm (Rock2)
Anatomy Link Frequency
muscle 2
anococcygeus 2
bladder 2
liver 1
spleen 1
Rock2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 24 96.52 Very High Very High Very High
agonist 3 89.40 High High
tetrodotoxin 3 89.16 High High
pain pelvic 4 51.16 Quite High
Pain 8 49.48 Quite Low
interstitial cystitis 16 49.12 Quite Low
imagery 8 36.56 Quite Low
fibrosis 4 27.52 Quite Low
Central nervous system 145 5.00 Very Low Very Low Very Low
Spinal cord 95 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 336 99.24 Very High Very High Very High
Overactive Bladder 112 98.72 Very High Very High Very High
Decapitation 4 78.52 Quite High
Neurological Disease 4 75.84 Quite High
Apoptosis 10 64.32 Quite High
Lower Urinary Tract Symptoms 20 54.24 Quite High
Starvation 4 52.08 Quite High
Chronic Pelvic Pain Syndrome 4 51.52 Quite High
Bladder Disease 8 50.16 Quite High
Interstitial Cystitis 16 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that the RhoA/ROK-mediated Ca(2+) sensitization pathway is expressed in anococcygeus and retractor penis muscles and enhances contractions produced by receptor-dependent and independent mechanisms.
Gene_expression (expressed) of ROK in muscles
1) Confidence 0.60 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.09
Observation of Rho-kinase and collagen subtype expression in bladder tissue
Gene_expression (expression) of Rho-kinase in bladder
2) Confidence 0.59 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 0.36 Pain Relevance 0.09
Therefore, we investigated changes in Rho-kinase expression after exposure to stress.
Gene_expression (expression) of Rho-kinase associated with stress
3) Confidence 0.59 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 0.84 Pain Relevance 0
Rho-kinase is present in the bladder muscle and is involved in contractions [12].
Gene_expression (present) of Rho-kinase in bladder
4) Confidence 0.59 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 0.85 Pain Relevance 0.05
is an indirect marker of detrusor muscle contractile response, because it is the mediator to the synthesis of Rho-kinase.
Gene_expression (synthesis) of Rho-kinase in muscle associated with overactive bladder
5) Confidence 0.59 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 0.95 Pain Relevance 0
Both anococcygeus and retractor penis showed a similar expression of RhoA, ROKalpha, and ROKbeta at the protein level as well as the mRNA for RhoGEFs.
Gene_expression (expression) of ROK in anococcygeus
6) Confidence 0.58 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.04
ROCKII is preferentially expressed in brain and muscle tissues, whereas ROCKI is abundantly expressed in nonneuronal tissues such as the liver, stomach, spleen, kidney, and testis.
Gene_expression (expressed) of ROCKII in stomach
7) Confidence 0.58 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0
Both anococcygeus and retractor penis showed a similar expression of RhoA, ROKalpha, and ROKbeta at the protein level as well as the mRNA for RhoGEFs.
Gene_expression (expression) of ROK in anococcygeus
8) Confidence 0.58 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.04
ROCKII is preferentially expressed in brain and muscle tissues, whereas ROCKI is abundantly expressed in nonneuronal tissues such as the liver, stomach, spleen, kidney, and testis.
Gene_expression (expressed) of ROCKII in testis
9) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0
ROCKII is preferentially expressed in brain and muscle tissues, whereas ROCKI is abundantly expressed in nonneuronal tissues such as the liver, stomach, spleen, kidney, and testis.
Gene_expression (expressed) of ROCKII in liver
10) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0
ROCKII is preferentially expressed in brain and muscle tissues, whereas ROCKI is abundantly expressed in nonneuronal tissues such as the liver, stomach, spleen, kidney, and testis.
Gene_expression (expressed) of ROCKII in kidney
11) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0
ROCKII is preferentially expressed in brain and muscle tissues, whereas ROCKI is abundantly expressed in nonneuronal tissues such as the liver, stomach, spleen, kidney, and testis.
Gene_expression (expressed) of ROCKII in spleen
12) Confidence 0.20 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2500253 Disease Relevance 0.06 Pain Relevance 0

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