INT126628

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.56
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Rock2) cytoskeleton (Rock2) nucleus (Rock2)
kinase activity (Rock2) microtubule organizing center (Rock2) cytoplasm (Rock2)
Anatomy Link Frequency
smooth muscle 1
Rock2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 6 97.80 Very High Very High Very High
agonist 1 97.76 Very High Very High Very High
Inflammation 3 88.64 High High
Spinal cord 3 82.80 Quite High
Hyperalgesia 3 80.92 Quite High
Antinociceptive 1 80.56 Quite High
tetrodotoxin 1 25.00 Low Low
Calcium channel 4 6.32 Low Low
Bioavailability 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Erectile Dysfunction 148 99.84 Very High Very High Very High
Diabetes Mellitus 56 99.56 Very High Very High Very High
Stress 88 99.32 Very High Very High Very High
Apoptosis 2 97.76 Very High Very High Very High
Increased Venous Pressure Under Development 28 96.40 Very High Very High Very High
INFLAMMATION 3 88.64 High High
Hyperalgesia 3 80.92 Quite High
Nociception 4 75.00 Quite High
Overactive Bladder 28 73.20 Quite High
Cardiovascular Disease 24 65.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of the RhoA/Rho-kinase (ROK) signaling represents a key step in the maintenance of agonist-induced contraction of smooth muscle.
Positive_regulation (Stimulation) of ROK in smooth muscle associated with agonist
1) Confidence 0.70 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15857612 Disease Relevance 0 Pain Relevance 0.05
Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p<0.05).
Positive_regulation (increased) of Rho-kinase associated with stress
2) Confidence 0.45 Published 2010 Journal Korean Journal of Urology Section Abstract Doc Link PMC2855479 Disease Relevance 0.79 Pain Relevance 0.05
Further functional analysis revealed that the underlying signal transduction pathways involve activation of the Rho-GTPases RhoA, Rac1 and Cdc42 and their corresponding downstream targets Rho-kinase (ROCK) and p21-activated kinase (PAK).
Positive_regulation (activation) of Rho-kinase
3) Confidence 0.14 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19896457 Disease Relevance 0.68 Pain Relevance 0.42
A mechanism for diabetes-induced erectile dysfunction was demonstrated in which upregulated RhoA/Rho-kinase levels were found in cavernosal tissue of streptozotocin-induced diabetic rats.
Positive_regulation (upregulated) of Rho-kinase associated with erectile dysfunction and diabetes mellitus
4) Confidence 0.08 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 0.80 Pain Relevance 0
A more recent study suggested that diabetic-associated ED due to upregulation of the penile RhoA/Rho-kinase pathway enhances PTEN/Akt activity leading to corporal apoptosis [91].
Positive_regulation (upregulation) of Rho-kinase associated with erectile dysfunction, diabetes mellitus and apoptosis
5) Confidence 0.08 Published 2010 Journal Advances in Pharmacological Sciences Section Body Doc Link PMC2997760 Disease Relevance 1.29 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox