INT126635

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Alox15) oxidoreductase activity (Alox15) nucleolus (Alox15)
nucleus (Alox15) cytoplasm (Alox15)
Anatomy Link Frequency
neurons 1
Alox15 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 9 100.00 Very High Very High Very High
dorsal root ganglion 6 98.36 Very High Very High Very High
substance P 1 97.92 Very High Very High Very High
qutenza 1 97.12 Very High Very High Very High
diclofenac 1 94.24 High High
cINOD 3 92.28 High High
Analgesic 1 88.96 High High
b2 receptor 3 85.44 High High
Potency 1 83.12 Quite High
Pain 2 73.64 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 98.36 Very High Very High Very High
Pain 2 73.64 Quite High
INFLAMMATION 3 71.24 Quite High
Cirrhosis 1 38.08 Quite Low
Cancer 1 37.32 Quite Low
Rheumatoid Arthritis 1 36.76 Quite Low
Increased Venous Pressure Under Development 1 35.88 Quite Low
Asthma 1 35.20 Quite Low
Disease 1 34.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Zaltoprofen also significantly inhibits bradykinin-induced 12-lipoxygenase (12-LOX) activity and the slow bradykinin-induced onset of substance P release from DRG neurons.
Negative_regulation (inhibits) of 12-LOX in neurons associated with dorsal root ganglion, bradykinin and substance p
1) Confidence 0.41 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15857630 Disease Relevance 0.62 Pain Relevance 1.36
Evaluation of 5-LOX metabolites-by LC/MS/MS and ELISA confirmed that both compounds selectively inhibited all products downstream of 5-hydroperoxy eicosatetraenoic acid (5-HPETE), including 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxoETE), without inhibition of 12-lipoxygenase (12-LOX), 15-lipoxygenase (15-LOX), or cyclooxygenase (COX) products.
Negative_regulation (inhibition) of 15-LOX
2) Confidence 0.15 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18295198 Disease Relevance 0.05 Pain Relevance 0.07

General Comments

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