INT126659

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 22
Total Number 22
Disease Relevance 2.04
Pain Relevance 4.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph1)
Anatomy Link Frequency
cumulus cells 4
enterochromaffin cells 3
neuronal 2
embryos 2
oocytes 2
Tph1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 253 99.98 Very High Very High Very High
medulla 4 98.16 Very High Very High Very High
monoamine 19 95.96 Very High Very High Very High
Raphe 65 94.16 High High
Neurotransmitter 31 90.08 High High
fluoxetine 66 85.00 Quite High
antidepressant 67 76.48 Quite High
Dopamine 56 70.16 Quite High
sSRI 60 65.08 Quite High
spastic colon 7 54.16 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 305 98.12 Very High Very High Very High
Bone Cancer 6 72.84 Quite High
Osteoporosis 10 71.88 Quite High
Handedness 24 67.24 Quite High
Functional Bowel Disorder 7 54.16 Quite High
Vomiting 15 53.00 Quite High
Anxiety Disorder 75 51.00 Quite High
Depression 28 50.64 Quite High
Neurodegenerative Disease 19 50.00 Quite Low
Menstral Migraine 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two isoforms of TPH have been discovered: TPH1, primarily expressed in the enterochromaffin cells of the gastrointestinal tract, and TPH2, expressed exclusively in neuronal cells.
Gene_expression (expressed) of TPH in enterochromaffin cells
1) Confidence 0.78 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0 Pain Relevance 0.13
Two isoforms of TPH have been discovered: TPH1, primarily expressed in the enterochromaffin cells of the gastrointestinal tract, and TPH2, expressed exclusively in neuronal cells.
Gene_expression (expressed) of TPH1 in enterochromaffin cells
2) Confidence 0.78 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0 Pain Relevance 0.13
Using a combination of reverse transcription-polymerase chain reaction analysis and immunofluorescence confocal microscopy, we showed that mouse cumulus cells, oocytes, and embryos contain 5-HT and SLC6A4, while only cumulus cells possess the 5-HT-producing enzyme TPH1 and may thus be the local source of 5-HT observed in their neighboring cells.
Gene_expression (producing) of TPH1 in cumulus cells
3) Confidence 0.78 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.28
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of TPH1 in oocytes
4) Confidence 0.78 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
Therefore, differential expression of the two isoforms of TPH was reflected in corresponding depletion of 5-HT content in the brain and periphery.
Gene_expression (expression) of TPH in brain
5) Confidence 0.77 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2565062 Disease Relevance 0.57 Pain Relevance 0.23
Two isoforms of TPH have been discovered: TPH1, primarily expressed in the enterochromaffin cells of the gastrointestinal tract, and TPH2, expressed exclusively in neuronal cells.
Gene_expression (expressed) of TPH in neuronal
6) Confidence 0.67 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0.05 Pain Relevance 0.15
Using a combination of reverse transcription-polymerase chain reaction analysis and immunofluorescence confocal microscopy, we showed that mouse cumulus cells, oocytes, and embryos contain 5-HT and SLC6A4, while only cumulus cells possess the 5-HT-producing enzyme TPH1 and may thus be the local source of 5-HT observed in their neighboring cells.
Gene_expression (5-HT-producing) of TPH1 in cumulus cells
7) Confidence 0.67 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.28
Two isoforms of TPH have been discovered: TPH1, primarily expressed in the enterochromaffin cells of the gastrointestinal tract, and TPH2, expressed exclusively in neuronal cells.
Gene_expression (expressed) of TPH1 in neuronal
8) Confidence 0.60 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18192499 Disease Relevance 0.05 Pain Relevance 0.15
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of tryptophan hydroxylase 1 in oocytes
9) Confidence 0.60 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
Gene_expression (Generation) of TPH1
10) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
Generation of TPH1, TPH2 and TPH1/TPH2 deficient animals
Gene_expression (Generation) of TPH1
11) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565062 Disease Relevance 0.58 Pain Relevance 0.08
TPH protein also was present in primary trigeminal cultures obtained from female Sprague-Dawley rats, but levels were not affected by 24-hour treatment with physiological levels (10(-9) M) of 17beta-estradiol.
Gene_expression (present) of TPH protein
12) Confidence 0.55 Published 2006 Journal Headache Section Body Doc Link 16942467 Disease Relevance 0 Pain Relevance 0
Assay for TPH activity
Gene_expression (activity) of TPH
13) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.05
Normally, LRP5 inhibits the expression of TPH1, the rate-limiting enzyme for serotonin production in enterochromaffin cells.
Gene_expression (expression) of TPH1 in enterochromaffin cells associated with serotonin
14) Confidence 0.35 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.14 Pain Relevance 0.21
The transcription factor Pet1 is expressed in serotonergic neurons and directly activates the transcription of genes that are involved in the synthesis (Tph and Aadc) and uptake (Sert) of serotonin.
Gene_expression (synthesis) of Tph in serotonergic neurons associated with serotonin
15) Confidence 0.30 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.56
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Gene_expression (express) of Tph in neurons associated with serotonin and monoamine
16) Confidence 0.30 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.37
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of TPH1 in cumulus cells
17) Confidence 0.26 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of TPH1 in embryos
18) Confidence 0.26 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of tryptophan hydroxylase 1 in cumulus cells
19) Confidence 0.20 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Gene_expression (production) of tryptophan hydroxylase 1 in embryos
20) Confidence 0.20 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.11

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