INT126667

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.45
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (HNF4A) nucleoplasm (HNF4A) nucleus (HNF4A)
DNA binding (HNF4A) cytoplasm (HNF4A)
Anatomy Link Frequency
nucleus 1
HNF4A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 2 58.48 Quite High
Glutamate 1 51.28 Quite High
tetrodotoxin 1 40.48 Quite Low
Calcium channel 1 35.52 Quite Low
conotoxin 1 29.68 Quite Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 100.00 Very High Very High Very High
Fatigue 1 92.36 High High
Anaerobic Bacterial Infections 1 38.48 Quite Low
Cancer 1 29.96 Quite Low
Disease 2 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low
Skin Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acetylation of transcription factors can alter their ability to bind DNA (in the cases of E2F1, p53, EKLF, GATA1, and HNF-4), to interact with other proteins (c-Jun, TCF, ACTR, and HNF-4), or to remain in the nucleus (HNF-4).
Localization (cases) of HNF-4 in nucleus
1) Confidence 0.06 Published 2002 Journal Genome Biol Section Body Doc Link PMC139359 Disease Relevance 0 Pain Relevance 0
We found that a secretary HIV transcription factor, transactivator of transcription (Tat), resets the murine circadian clock, in vitro and in vivo, at clinically relevant concentrations (EC(50) = 0.31 nM).
Localization (secretary) of transcription associated with acquired immune deficiency syndrome or hiv infection
2) Confidence 0.01 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15860648 Disease Relevance 0.45 Pain Relevance 0.08

General Comments

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