INT126683

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.87
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
lipid metabolic process (Lipg)
Anatomy Link Frequency
Adipocytes 2
limbs 1
duct 1
Lipg (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 20 100.00 Very High Very High Very High
Pain 1 99.90 Very High Very High Very High
backache 1 97.52 Very High Very High Very High
Inflammation 161 88.84 High High
qutenza 1 65.16 Quite High
Chronic pancreatitis 2 50.00 Quite Low
agonist 23 41.92 Quite Low
headache 2 34.88 Quite Low
Inflammatory mediators 18 25.88 Quite Low
anesthesia 3 24.12 Low Low
Disease Link Frequency Relevance Heat
Pain 1 99.90 Very High Very High Very High
Obesity 140 99.74 Very High Very High Very High
Disorder Of Lipid Metabolism 5 99.16 Very High Very High Very High
Overdose 2 99.16 Very High Very High Very High
Low Back Pain 1 97.52 Very High Very High Very High
Thrombocytopenia 6 91.92 High High
Neutropenia 5 91.08 High High
Fatty Liver 1 90.64 High High
INFLAMMATION 186 88.84 High High
Body Weight 3 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RK significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells.
Localization (translocation) of lipase in fat cells associated with obesity
1) Confidence 0.70 Published 2005 Journal Life Sci. Section Abstract Doc Link 15862604 Disease Relevance 0.66 Pain Relevance 0.07
Twelve patients had treatment interruptions due to pain and lipase elevation.
Localization (elevation) of lipase associated with pain
2) Confidence 0.23 Published 2008 Journal OncoTargets and therapy Section Body Doc Link PMC2994207 Disease Relevance 0.93 Pain Relevance 0.20
Finally, endothelial lipase (EL) might hydrolyze HDL phospholipids,
Localization (endothelial) of lipase associated with disorder of lipid metabolism
3) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.52 Pain Relevance 0.07
In the second series of experiments, adult (3-mo-old) male C57BL/6 mice were killed with an overdose of pentobarbitone sodium, and soleus and EDL muscles were rapidly removed from both limbs in random order.
Localization (muscles) of EDL in limbs associated with overdose
4) Confidence 0.09 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.10 Pain Relevance 0
The high loading capacity of the micelles, the high stability of mTHPC-loaded micelles above the CAC, and the lipase-induced release of the photosensitizer makes these micelles very promising carriers for photodynamic therapy in vivo.



Localization (release) of lipase
5) Confidence 0.05 Published 2008 Journal Pharm Res Section Abstract Doc Link PMC2515570 Disease Relevance 0.07 Pain Relevance 0
Adipocytes express and secrete a variety of adipokines including cytokines, growth factors, adiponectin, resistin, adipsin, leptin, acylation stimulating protein, plasminogen activator inhibitor-1 (PAI-1), lipoprotein lipase, and components of the renin-angiotensin system which may exert local (autocrine/paracrine) and systemic (endocrine) effects [67–69].

5.2.

Localization (secrete) of lipase in Adipocytes associated with obesity and cytokine
6) Confidence 0.04 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.51 Pain Relevance 0.13
RESULTS: There were inverse correlations of EUS consensus score with both duct-cell bicarbonate secretion (R = -0.71, P < .001) and acinar-cell lipase secretion (R = -0.52, P < .001).
Localization (secretion) of acinar-cell lipase in duct
7) Confidence 0.01 Published 2009 Journal Clin. Gastroenterol. Hepatol. Section Body Doc Link 18955165 Disease Relevance 0.08 Pain Relevance 0

General Comments

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