INT1267

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Context Info
Confidence 0.44
First Reported 1976
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.39
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (G6PC) endoplasmic reticulum (G6PC) carbohydrate metabolic process (G6PC)
transmembrane transport (G6PC)
Anatomy Link Frequency
bile 2
G6PC (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 6 99.84 Very High Very High Very High
Bile 122 99.42 Very High Very High Very High
agonist 6 85.04 High High
dexamethasone 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Piles 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 38 98.62 Very High Very High Very High
Myeloid Leukemia 9 91.92 High High
Stress 1 91.80 High High
Neutropenia 13 84.52 Quite High
Apoptosis 1 82.44 Quite High
Injury 1 75.00 Quite High
Communicable Diseases 1 69.56 Quite High
Bordatella Infection 6 60.48 Quite High
Myeloproliferative Disorder 2 59.36 Quite High
Congenital Anomalies 2 54.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the current study, the chronic bile fistula (CBF) rat model and primary rat hepatocytes (PRH) were used to study the regulation of gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) and the gene encoding short heterodimeric partner (SHP) by taurocholate (TCA).
Regulation (regulation) of glucose-6-phosphatase in bile associated with bile and fistula
1) Confidence 0.44 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.13
A G6PT-deficiency in the CD34+ progenitor might therefore be of functional relevance, in particular for the regular differentiation along the myeloid pathway while erythropoiesis and thrombopoiesis are not affected.
Neg (not) Regulation (affected) of G6PT-deficiency
2) Confidence 0.33 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2566578 Disease Relevance 0.72 Pain Relevance 0
Bile acids have been reported to regulate the rate-limiting gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) in various cell culture and animal models (4, 23–28).
Regulation (regulate) of glucose-6-phosphatase in Bile associated with bile
3) Confidence 0.26 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.33
Glucose-6-phosphatase and UDP-glucuronyl transferase were not significantly affected by acetaminophen or furosemide administration, and neither diene conjugation nor hepatic triglycerides were increased.
Neg (not) Regulation (affected) of Glucose-6-phosphatase associated with paracetamol
4) Confidence 0.07 Published 1976 Journal Pharmacology Section Abstract Doc Link 183224 Disease Relevance 0.07 Pain Relevance 0.51

General Comments

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