INT126711

Context Info Confidence 0.60 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 7 Disease Relevance 0.44 Pain Relevance 1.03

oxidoreductase activity (Bcmo1)

Anatomy Link Frequency cavity 1 Bcmo1 (Mus musculus)

Pain Link Frequency Relevance Heat cINOD 4 100.00 tramadol 7 98.84 Inflammatory response 54 67.84 Inflammation 60 5.00 cytokine 12 5.00 alcohol 6 5.00 ketamine 3 5.00 anesthesia 3 5.00 isoflurane 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 118 100.00 Targeted Disruption 21 50.00 Nicotine Addiction 45 5.00 Lung Cancer 21 5.00 Infection 21 5.00 Cancer 9 5.00 Necrosis 6 5.00 Communicable Diseases 3 5.00 Cardiovascular Disease 3 5.00 Stress 3 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of the genes aIfi44,bIfi27,cTrim12 and dIsg15 in Bcmo1?

Gene_expression (expression) of Bcmo1

1) Confidence 0.60 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0.07 Pain Relevance 0.03

Therefore, we evaluated gene expression of these 121 genes in all four groups; Bcmo1+/+ control mice, Bcmo1+/+ mice with supplementation of BC, Bcmo1?

Gene_expression (expression) of Bcmo1

2) Confidence 0.60 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0 Pain Relevance 0

Therefore, we evaluated gene expression of these 121 genes in all four groups; Bcmo1+/+ control mice, Bcmo1+/+ mice with supplementation of BC, Bcmo1?

Gene_expression (expression) of Bcmo1

3) Confidence 0.53 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2877315 Disease Relevance 0 Pain Relevance 0

Three beta-cyclodextrin (beta-CD) conjugates of non-steroidal anti-inflammatory drugs were synthesized by enzymatic methods.

Gene_expression (synthesized) of beta-CD associated with inflammation and cinod

4) Confidence 0.14 Published 2005 Journal Bioorg. Med. Chem. Section Abstract Doc Link 15862995 Disease Relevance 0.17 Pain Relevance 0.17

However, in beta-CD, due to space restriction of the CD cavity, a weak interaction is present between the above groups in tramadol. beta-Cyclodextrin studies show that tramadol forms 1:2 inclusion complex with beta-CD.

Gene_expression (present) of beta-CD in cavity associated with tramadol

5) Confidence 0.10 Published 2009 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 19665424 Disease Relevance 0 Pain Relevance 0.63

The vibrational dynamics of solid inclusion complexes of the nonsteroidal anti-inflammatory drug Ibuprofen (IBP) with beta-cyclodextrin (beta-CD) and methyl-beta-cyclodextrin (Me-beta-CD) has been investigated by using attenuated total reflection-Fourier transform infrared FTIR-ATR spectroscopy, in order to monitor the changes induced, as a consequence of complexation, on the vibrational spectrum of IBP, in the wavenumber range 600-4000 cm(-1).

Gene_expression (beta-cyclodextrin) of beta-CD associated with inflammation and cinod

6) Confidence 0.05 Published 2010 Journal J Phys Chem A Section Abstract Doc Link 20524676 Disease Relevance 0.10 Pain Relevance 0.10

The vibrational dynamics of solid inclusion complexes of the nonsteroidal anti-inflammatory drug Ibuprofen (IBP) with beta-cyclodextrin (beta-CD) and methyl-beta-cyclodextrin (Me-beta-CD) has been investigated by using attenuated total reflection-Fourier transform infrared FTIR-ATR spectroscopy, in order to monitor the changes induced, as a consequence of complexation, on the vibrational spectrum of IBP, in the wavenumber range 600-4000 cm(-1).

Gene_expression (methyl-beta-cyclodextrin) of Me-beta-CD associated with inflammation and cinod

7) Confidence 0.05 Published 2010 Journal J Phys Chem A Section Abstract Doc Link 20524676 Disease Relevance 0.10 Pain Relevance 0.10

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