INT126716

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.31
Pain Relevance 3.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6r) extracellular region (Il6r) enzyme binding (Il6r)
Anatomy Link Frequency
pituitary gland 2
synovial fluid 1
arcuate nucleus 1
SGC 1
dorsal root ganglion 1
Il6r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 61 100.00 Very High Very High Very High
cytokine 13 100.00 Very High Very High Very High
Neuropeptide 12 100.00 Very High Very High Very High
substance P 2 100.00 Very High Very High Very High
Peripheral nerve injury 1 99.64 Very High Very High Very High
Sciatic nerve 4 98.98 Very High Very High Very High
rheumatoid arthritis 85 98.96 Very High Very High Very High
Eae 8 98.54 Very High Very High Very High
dorsal root ganglion 2 98.36 Very High Very High Very High
agonist 2 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 54 100.00 Very High Very High Very High
Nervous System Injury 1 99.64 Very High Very High Very High
Rheumatoid Arthritis 107 98.96 Very High Very High Very High
Injury 8 98.54 Very High Very High Very High
Ganglion Cysts 2 97.88 Very High Very High Very High
Hyperalgesia 21 87.20 High High
Neuropathic Pain 5 86.56 High High
Arthritis 62 85.36 High High
Appetite Loss 14 82.60 Quite High
Diabetic Nephropathy 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The equation describing the up-regulation of IL-6 receptor type 1 mRNA (IL6R1m) time profile following MPL treatment is:
Positive_regulation (regulation) of IL6R1m
1) Confidence 0.42 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733097 Disease Relevance 0 Pain Relevance 0.12
In peripheral nerve injury models, IL-6 and IL-6R are increased at the injured nerve and the respective dorsal root ganglion.
Positive_regulation (increased) of IL-6R in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nervous system injury and peripheral nerve injury
2) Confidence 0.15 Published 2005 Journal Cytokine Section Abstract Doc Link 15863388 Disease Relevance 0.46 Pain Relevance 0.41
We used immunofluorescence and in situ hybridization methods to provide evidence that chronic constriction injury (CCI) of the sciatic nerve induces synthesis of interleukin-6 (IL-6) in SGC, elevation of IL-6 receptor (IL-6R) and activation of signal transducer and activator of transcription 3 (STAT3) signalling.
Positive_regulation (elevation) of IL-6R in SGC associated with eae, injury and sciatic nerve
3) Confidence 0.15 Published 2010 Journal Neuron Glia Biol. Section Abstract Doc Link 20519054 Disease Relevance 0.65 Pain Relevance 0.59
Double-staining confocal microscopy showed the positive immunoreactivity of IL-6R and AMPK in the hypothalamic arcuate nucleus of rats 60 minutes after i.c.v. saline or IL-6 (200 ng) infusion.
Positive_regulation (immunoreactivity) of IL-6R in arcuate nucleus
4) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Of note, recent work suggests that NPS-NPSR1 signalling might be involved in the modulation of inflammatory and anti-bacterial responses in T cells and macrophages.[12] NPS stimulation of epithelial cells stably transfected with NPSR1 results in the induction of expression, among others, of the neuropeptide substance P (SP), the pro-inflammatory cytokine interleukin 8 (IL8), and the interleukin 6 receptor (IL6R), together with the alpha subunit common to the 4 pituitary gland hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH).[16] Hence, similar to other neuropeptides and their receptors, NPSR1 appears to play a dual role along the hypothalamic-pituitary-adrenal (HPA) axis and in inflammation, and polymorphisms affecting its expression or function might thus perturb physiological responses ultimately leading to chronic inflammation and RA.
Positive_regulation (n the ind) of interleukin 6 receptor in pituitary gland associated with inflammation, rheumatoid arthritis, neuropeptide, cytokine and substance p
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 1.05 Pain Relevance 0.70
Of note, recent work suggests that NPS-NPSR1 signalling might be involved in the modulation of inflammatory and anti-bacterial responses in T cells and macrophages.[12] NPS stimulation of epithelial cells stably transfected with NPSR1 results in the induction of expression, among others, of the neuropeptide substance P (SP), the pro-inflammatory cytokine interleukin 8 (IL8), and the interleukin 6 receptor (IL6R), together with the alpha subunit common to the 4 pituitary gland hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH) and thyroid stimulating hormone (TSH).[16] Hence, similar to other neuropeptides and their receptors, NPSR1 appears to play a dual role along the hypothalamic-pituitary-adrenal (HPA) axis and in inflammation, and polymorphisms affecting its expression or function might thus perturb physiological responses ultimately leading to chronic inflammation and RA.
Positive_regulation (n the ind) of IL6R in pituitary gland associated with inflammation, rheumatoid arthritis, neuropeptide, cytokine and substance p
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2825264 Disease Relevance 1.05 Pain Relevance 0.70
In fact, in the serum, synovial fluid and synovial tissue of rheumatoid arthritis patients the concentrations of both IL-6 [6,7] and sIL-6R [8,9] are elevated.
Positive_regulation (elevated) of sIL-6R in synovial fluid associated with rheumatoid arthritis
7) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.85 Pain Relevance 0.58
The increase in responses to IL-6 and IL-6 plus sIL-6R was prevented by coadministration of soluble glycoprotein 130 (sgp130), but sgp130 did not reverse established mechanical hyperexcitability.
Positive_regulation (increase) of sIL-6R
8) Confidence 0.02 Published 2007 Journal Arthritis Rheum. Section Body Doc Link 17195239 Disease Relevance 0.07 Pain Relevance 0

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