INT126725

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Context Info
Confidence 0.53
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (CNN1)
Anatomy Link Frequency
smooth muscle 2
Uterus 1
skeletal muscle 1
CNN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 96.72 Very High Very High Very High
agonist 59 96.12 Very High Very High Very High
abdominal pain 2 94.40 High High
Inflammation 39 91.84 High High
Dismenorea 2 77.04 Quite High
Neuropeptide 1 75.12 Quite High
Kinase C 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
bradykinin 10 5.00 Very Low Very Low Very Low
adenocard 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diarrhoea 2 94.96 High High
Abdominal Pain 2 94.40 High High
Hot Flashes 2 93.76 High High
Fever 2 93.20 High High
Appetite Loss 2 92.92 High High
INFLAMMATION 37 91.84 High High
Leiomyosarcoma 12 86.48 High High
Dysmenorrhea 2 77.04 Quite High
Starvation 1 65.68 Quite High
Teratoma 2 48.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The hTERT-HM cells expressed TAGLN, PGR, ACTA2, CNN1 and PTGS2 (Figure 1B(i–v)).
Gene_expression (expressed) of CNN1
1) Confidence 0.53 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], alpha-smooth muscle actin 1/3 [focal], calponin [1/3], caldesmon [0/3], and myogenin [0/3]).
Gene_expression (expression) of calponin in skeletal muscle
2) Confidence 0.33 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.31 Pain Relevance 0.33
Immunohistochemical studies revealed diffuse positivity for desmin and poor expression for other smooth muscle and skeletal muscle markers (muscle-specific actin [0/3], alpha-smooth muscle actin 1/3 [focal], calponin [1/3], caldesmon [0/3], and myogenin [0/3]).
Gene_expression (expression) of calponin in smooth muscle
3) Confidence 0.11 Published 2005 Journal Int. J. Surg. Pathol. Section Abstract Doc Link 15864383 Disease Relevance 1.31 Pain Relevance 0.33
Uterus SMCs also have especially high expression levels of many genes that encode the contractile machinery of SMCs, including tropomyosin 1 and 2, calponin, caldesmon 1, SM-?
Gene_expression (expression) of calponin in Uterus
4) Confidence 0.08 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.08 Pain Relevance 0.21
In addition, contractile function of cultured ASM cells is rapidly diminished, coinciding with reduced expression of smooth muscle alpha-actin and myosin heavy chain, calponin, h-caldesmon, beta-tropomyosin, and myosin light chain kinase (MLCK) [22].
Gene_expression (expression) of calponin in smooth muscle
5) Confidence 0.01 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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