INT126732

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.13
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 2 100.00 Very High Very High Very High
addiction 28 94.64 High High
Dismenorea 4 89.04 High High
Opioid 14 78.76 Quite High
cocaine 38 75.28 Quite High
antagonist 16 73.32 Quite High
Morphine 36 61.64 Quite High
Glutamate receptor 2 6.32 Low Low
Nicotine 18 5.00 Very Low Very Low Very Low
Dopamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 82 99.46 Very High Very High Very High
Stress 25 99.12 Very High Very High Very High
Nasopharynx Cancer 106 97.72 Very High Very High Very High
Apoptosis 32 95.08 Very High Very High Very High
Aging 2 75.68 Quite High
Endometriosis 4 75.00 Quite High
Toxicity 1 70.96 Quite High
Repression 1 53.52 Quite High
Colon Cancer 6 28.00 Quite Low
Reprotox - General 1 4 27.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pattern B genes modulate various aspects of cell functioning: hexose transport (Slc2a1), lipid metabolism (Angptl4, Pparg), regulation of sodium channels and the actin cytoskeleton (Sgk1) and regulation of the cell cycle (Cdkn1a), to mention just a few [81-84].
Regulation (regulation) of Cdkn1a associated with sodium channel
1) Confidence 0.39 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.09 Pain Relevance 0.46
TFAP2A plays crucial role in tumor growth and progression by regulation of E-cadherin, MMP-2, c-kit, p21WAF-1, HER-2, BCL-2, insulin like growth factor receptor-1 and Smad signaling [25].
Regulation (regulation) of p21WAF associated with cancer
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2958829 Disease Relevance 0.92 Pain Relevance 0
Because researchers have reported that cell cycle-regulating molecules, such as p21, p53, and TGF-?
Regulation (regulating) of p21
3) Confidence 0.15 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.42 Pain Relevance 0
Analysis of pattern B2 revealed the enrichment of genes connected to enzyme inhibitor activity (8.9-fold, P < 0.05; for example, Cdkn1a, Angptl4), the stress response (4.2-fold, P < 0.01; for example, Cdkn1a, Tsc22d3) and regulation of cell differentiation (2.5-fold, P < 0.05; for example, Plekhf1, Zbtb16).
Regulation (regulation) of Cdkn1a associated with stress
4) Confidence 0.10 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0.19 Pain Relevance 0
However, Van Poznak et al. and Zhang et al. suggested that gossypol-induced cell cycle arrest is associated with alterations of p21, cyclin D1, and p53 and showed that p21 is the first target of gossypol to inhibit cell growth in vivo [9,20].
Regulation (alterations) of p21
5) Confidence 0.09 Published 2009 Journal J Transl Med Section Body Doc Link PMC2742515 Disease Relevance 0.36 Pain Relevance 0
OBJECTIVE: p53, MDM2, and p21Waf1 are oncoproteins that regulate the cell cycle.
Regulation (regulate) of p21Waf1
6) Confidence 0.00 Published 2005 Journal J. Soc. Gynecol. Investig. Section Abstract Doc Link 15866118 Disease Relevance 0.15 Pain Relevance 0.16

General Comments

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