INT126734

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 5.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MDM2) intracellular (MDM2) enzyme binding (MDM2)
protein complex assembly (MDM2) protein complex (MDM2) ligase activity (MDM2)
MDM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 4 50.00 Quite Low
palliative 1 47.24 Quite Low
Inflammation 24 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
chemokine 5 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 149 100.00 Very High Very High Very High
Watson Syndrome 14 100.00 Very High Very High Very High
Mantle-cell Lymphoma 33 99.84 Very High Very High Very High
Stress 22 97.72 Very High Very High Very High
Shock 23 95.96 Very High Very High Very High
Apoptosis 290 94.44 High High
Nerve Sheath Neoplasms 25 93.92 High High
Congenital Anomalies 7 93.04 High High
Metaplasia 1 90.04 High High
Neurofibroma 5 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Biallelic inactivation of NF1 and mutations of numerous additional tumor suppressor genes within the p19ARF-MDM2-TP53 and p16INK4A-Rb signaling cascades have been identified in MPNSTs [12,13].
Positive_regulation (inactivation) of MDM2 associated with cancer and watson syndrome
1) Confidence 0.49 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2881068 Disease Relevance 1.96 Pain Relevance 0
In contrast, all 31 adenomyosis tissue samples were negative for p53, MDM2, and p21Waf1 expression.
Positive_regulation (negative) of MDM2
2) Confidence 0.40 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.15 Pain Relevance 0
All endometrioma tissue samples expressing p53 also tested positive for both MDM2 and p21Waf1.
Positive_regulation (positive) of MDM2
3) Confidence 0.40 Published 2005 Journal J. Soc. Gynecol. Investig. Section Body Doc Link 15866118 Disease Relevance 0.16 Pain Relevance 0
Cadmium may activate oncogenes such as c-myc, mdm2, and cellular tumor antigen p53; inhibit tumor suppressor genes such as wild-type p53 and p27; and consequently promote the proliferation of initiated cells (Fang et al. 2002).
Positive_regulation (activate) of mdm2 associated with cancer
4) Confidence 0.29 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1332665 Disease Relevance 0.57 Pain Relevance 0
Interestingly, MDM2 was induced in the U versus WT comparison in addition to the significant induction of JUN.
Positive_regulation (induced) of MDM2
5) Confidence 0.28 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.43 Pain Relevance 0
For example, mapping transcriptional changes based on upstream regulatory pathways revealed activation of the DNA damage (HDM2; TP53INP1), antioxidant (HMOX1; SCL3A2; GCLM; NQO1), ER stress (ASNS; CTH; ATF3; GADD154), and heat shock (HSPA1A; HSPB1; HSPH1; DNAJB1) responses (Table 1).
Positive_regulation (activation) of HDM2 associated with stress and shock
6) Confidence 0.28 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.26 Pain Relevance 0
the HDM2 promoter leading to HDM2 overexpression has been recently associated
Positive_regulation (leading) of HDM2
7) Confidence 0.20 Published 2008 Journal PPAR Research Section Body Doc Link PMC2423003 Disease Relevance 1.05 Pain Relevance 0
Another gene that is responsible for suppressing p53 and directly degrades the protein, MDM2 [67], was induced in WTSTS cells.
Positive_regulation (induced) of MDM2
8) Confidence 0.19 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.33 Pain Relevance 0
Notably, elevated Pim-1 correlates with elevated Mdm2 in MCL.
Positive_regulation (elevated) of Mdm2 associated with mantle-cell lymphoma
9) Confidence 0.13 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 0.66 Pain Relevance 0

General Comments

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