INT126736

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 0.42
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Nrg1) extracellular space (Nrg1) cell morphogenesis (Nrg1)
plasma membrane (Nrg1) cytoplasm (Nrg1)
Nrg1 (Mus musculus)
Pain Link Frequency Relevance Heat
conotoxin 1 99.68 Very High Very High Very High
Pain 1 98.80 Very High Very High Very High
Neurotransmitter 20 92.84 High High
Hippocampus 5 86.08 High High
Calcium channel 6 80.04 Quite High
Glutamate 15 78.00 Quite High
excitatory amino acid 5 77.20 Quite High
Nicotine 60 75.40 Quite High
anesthesia 1 74.76 Quite High
analgesia 1 74.28 Quite High
Disease Link Frequency Relevance Heat
Pain 1 98.80 Very High Very High Very High
Schizophrenia 25 93.08 High High
Lifespan 5 56.00 Quite High
Myelodysplastic Syndromes 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of Type III Nrg1 back signaling induces an increase in axonal surface ?
Positive_regulation (Stimulation) of Gene_expression (back) of Nrg1
1) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.05
Because we do not see effects of Type III Nrg1 back signaling on ?
Neg (not) Positive_regulation (effects) of Gene_expression (effects) of Nrg1
2) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.15
Acute stimulation of Type III Nrg1 back signaling increases the number of ?
Positive_regulation (stimulation) of Gene_expression (back) of Nrg1
3) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0.04
Stimulation of Type III Nrg1 back signaling increases surface expression of ?
Positive_regulation (Stimulation) of Gene_expression (back) of Nrg1
4) Confidence 0.50 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0 Pain Relevance 0
It is worth noting that these risk alleles at the NRG1 locus also have been associated with increased expression of Type I and IV Nrg1 (Law et al., 2006).
Positive_regulation (increased) of Gene_expression (expression) of Nrg1
5) Confidence 0.46 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364689 Disease Relevance 0.32 Pain Relevance 0.04
Production of HWTX-I by this method has the major advantages of high efficiency and low cost.
Positive_regulation (Production) of Gene_expression (Production) of HWTX-I
6) Confidence 0.01 Published 2009 Journal Protein Expr. Purif. Section Abstract Doc Link 19217942 Disease Relevance 0 Pain Relevance 0.34
Production of HWTX-I by the bacterium or yeast expression systems resulted in poor yields and the purified protein was proved to have lower biological activity than that of native one.
Positive_regulation (Production) of Gene_expression (Production) of HWTX-I
7) Confidence 0.01 Published 2005 Journal Protein Expr. Purif. Section Abstract Doc Link 15866735 Disease Relevance 0.10 Pain Relevance 0.10

General Comments

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