INT126743

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 61
Total Number 63
Disease Relevance 50.02
Pain Relevance 11.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (LEP) extracellular region (LEP) lipid metabolic process (LEP)
Anatomy Link Frequency
fat 18
peritoneal fluid 6
plasma 6
adipose tissue 6
body 4
LEP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 8 99.92 Very High Very High Very High
cytokine 271 99.82 Very High Very High Very High
Kinase C 12 99.76 Very High Very High Very High
Cholecystokinin 27 99.52 Very High Very High Very High
endometriosis 23 99.52 Very High Very High Very High
Angina 18 99.40 Very High Very High Very High
Osteoarthritis 423 98.20 Very High Very High Very High
pain pelvic 10 97.20 Very High Very High Very High
Inflammation 497 96.96 Very High Very High Very High
Catecholamine 6 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 2370 100.00 Very High Very High Very High
Syndrome 97 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 88 100.00 Very High Very High Very High
Atherosclerosis 9 100.00 Very High Very High Very High
Hypoxia 231 99.98 Very High Very High Very High
Low Back Pain 9 99.92 Very High Very High Very High
Morbid Obesity 6 99.90 Very High Very High Very High
Reprotox - General 3 70 99.80 Very High Very High Very High
Pulmonary Disease 380 99.58 Very High Very High Very High
Acute Coronary Syndrome 5 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several studies have shown that the systemic administration of recombinant TNF increases leptin gene expression from fat tissue [17, 18].
Positive_regulation (increases) of Gene_expression (expression) of leptin gene in fat
1) Confidence 0.66 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.99 Pain Relevance 0.35
The cytokine-induced increase in leptin expression or its serum levels and reduction in
Positive_regulation (increase) of Gene_expression (expression) of leptin associated with cytokine
2) Confidence 0.66 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.92 Pain Relevance 0.47
In another study, Creutzberg et al. [83] documented impairments of normal leptin feedback mechanisms during exacerbations of COPD suggesting that elevated leptin concentrations might represent an up-regulation of leptin mRNA in adipose tissue resulting in an enhanced leptin production in such patients.
Positive_regulation (enhanced) of Gene_expression (production) of leptin in adipose tissue associated with pulmonary disease and obesity
3) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.48 Pain Relevance 0.18
Interestingly, increased leptin expression in bronchial mucosa was observed in patients with COPD, in association with airway inflammation and airflow obstruction [112, 114].
Positive_regulation (increased) of Gene_expression (expression) of leptin associated with pulmonary disease and inflammation
4) Confidence 0.59 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2857618 Disease Relevance 1.29 Pain Relevance 0.23
The aims of the present study were to investigate serum leptin concentrations in patients with ST-elevated myocardial infarction (STEMI) and with chronic stable angina pectoris (CSAP) and to evaluate the possible correlations of leptin to other atherosclerotic risk factors; including serum high sensitive C-reactive protein (Hs-CRP), serum homocysteine, and fibrinogen concentrations.
Positive_regulation (sensitive) of Gene_expression (concentrations) of leptin associated with stable angina pectoris, angina, atherosclerosis and myocardial infarction
5) Confidence 0.50 Published 2006 Journal Angiology Section Abstract Doc Link 16703186 Disease Relevance 1.22 Pain Relevance 0.51
Thus, in patients with morbid obesity, an increase in leptin production by the enlarged fat mass would be futile [58].
Positive_regulation (increase) of Gene_expression (production) of leptin in fat associated with morbid obesity
6) Confidence 0.50 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.54 Pain Relevance 0.03
In these studies, leptin administered peripherally produced increase in RSNA in both obese and lean mice, but failed to decrease food intake and body weight in the obese mice to a similar degree as it did in their lean littermates.
Positive_regulation (increase) of Gene_expression (produced) of leptin in body associated with body weight and obesity
7) Confidence 0.50 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993994 Disease Relevance 1.33 Pain Relevance 0
A relationship between increased peritoneal leptin levels and infertility in endometriosis.
Positive_regulation (increased) of Gene_expression (levels) of leptin associated with endometriosis and reprotox - general 3
8) Confidence 0.48 Published 2008 Journal Gynecol. Endocrinol. Section Title Doc Link 18958774 Disease Relevance 1.08 Pain Relevance 0.40
postreatment leptin levels of the patients were still
Positive_regulation (postreatment) of Gene_expression (levels) of leptin
9) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.41 Pain Relevance 0.03
Although female patients had higher pretreatment leptin
Positive_regulation (pretreatment) of Gene_expression (had) of leptin
10) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.44 Pain Relevance 0.03
On the other hand, Van Crevel et al. [24] have shown that both plasma leptin and ex vivo IFN-gamma production were low and increased upon successful antituberculous treatment.
Positive_regulation (increased) of Gene_expression (production) of leptin in plasma
11) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.80 Pain Relevance 0.03
and cytokines such as TNF and IL-1 increase leptin expression dose
Positive_regulation (increase) of Gene_expression (expression) of leptin associated with cytokine
12) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 1.86 Pain Relevance 0.44
higher posttreatment leptin levels (4.38±2.95 versus 3.18±4.26 ng/mL) than the male patients, they were not
Positive_regulation (posttreatment) of Gene_expression (levels) of leptin
13) Confidence 0.48 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.43 Pain Relevance 0.03
In this respect, leptin levels for all groups except CON (P = 0.07) experienced significant reductions (P < 0.001 to <0.05) after the first two weeks of dieting, which restricted caloric intake to the greatest extent.


Positive_regulation (experienced) of Gene_expression (levels) of leptin associated with overnutrition
14) Confidence 0.47 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2693519 Disease Relevance 0.40 Pain Relevance 0
In the current study, the elevated concentration of leptin actually induced the phosphorylation of STAT 1?
Positive_regulation (induced) of Gene_expression (concentration) of leptin
15) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.68 Pain Relevance 0.04
Besides, MMP-13 was overexpressed in leptin-stimulated chondrocytes obtained from obese OA patients, and this was shown from the lowest concentration of leptin.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of leptin in chondrocytes associated with obesity and osteoarthritis
16) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.14 Pain Relevance 0.24
In the current study, the elevated concentration of leptin actually induced the phosphorylation of STAT 1?
Positive_regulation (concentration) of Gene_expression (concentration) of leptin
17) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.68 Pain Relevance 0.04
In the current study, the elevated concentration of leptin actually induced the phosphorylation of STAT 1?
Positive_regulation (elevated) of Gene_expression (concentration) of leptin
18) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.68 Pain Relevance 0.04
The downstream targets of leptin identified in the current study are in agreement with those previously published because IGF-1, type 2 collagen and MMP-13 were overexpressed upon leptin stimulation [9-12].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of leptin
19) Confidence 0.47 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 1.54 Pain Relevance 0.37
Under experimental conditions, intermittent hypoxia stimulates leptin production and a number of studies have demonstrated that serum leptin levels are elevated in OSA patients, independently of obesity [18,26-32] despite some couldn't find that relationship when controlled for body fat [12,33,34].
Positive_regulation (stimulates) of Gene_expression (production) of leptin in body associated with apnoea, hypoxia and obesity
20) Confidence 0.47 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2567288 Disease Relevance 1.12 Pain Relevance 0.09

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