INT126748

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 26
Total Number 31
Disease Relevance 11.15
Pain Relevance 7.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
neuronal 6
endothelial cells 4
neurons 4
hepatocytes 2
epithelial cells 2
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 183 100.00 Very High Very High Very High
neuralgia 2 100.00 Very High Very High Very High
qutenza 12 99.98 Very High Very High Very High
Sciatic nerve 5 99.98 Very High Very High Very High
bDMF 24 99.76 Very High Very High Very High
Spinal cord 9 99.40 Very High Very High Very High
Neuropathic pain 5 99.12 Very High Very High Very High
dorsal root ganglion 12 98.92 Very High Very High Very High
nociceptor 4 98.52 Very High Very High Very High
Dopamine 70 97.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myocardial Infarction 338 100.00 Very High Very High Very High
Stress 48 99.88 Very High Very High Very High
Neuropathic Pain 5 99.12 Very High Very High Very High
Ganglion Cysts 12 98.92 Very High Very High Very High
Targeted Disruption 25 98.44 Very High Very High Very High
Toxicity 5 98.28 Very High Very High Very High
Apoptosis 78 98.16 Very High Very High Very High
Diabetes Mellitus 252 98.10 Very High Very High Very High
Hyperglycemia 40 97.72 Very High Very High Very High
Cognitive Disorder 16 97.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to VEGF, there might be other factors which could induce the elevation of Akt in neuronal cells.
Positive_regulation (induce) of Positive_regulation (elevation) of Akt in neuronal
1) Confidence 0.55 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.24 Pain Relevance 0.12
Activation of Akt requires the phosphorylation of Ser473 within the carboxyl-terminal hydrophobic motif, which primarily facilitates the phosphorylation of Thr308 in the activation loop to fully activate Akt kinase activity [12].
Positive_regulation (requires) of Positive_regulation (Activation) of Akt
2) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.49 Pain Relevance 0.21
Increase in reactive oxygen species and activation of Akt signaling pathway in neuropathic pain.
Positive_regulation (Increase) of Positive_regulation (activation) of Akt associated with neuralgia and neuropathic pain
3) Confidence 0.48 Published 2008 Journal Cell. Mol. Neurobiol. Section Title Doc Link 18379870 Disease Relevance 0.70 Pain Relevance 0.91
In contrast, inhibition of 5-HT-mediated RhoA degradation by MG132 prevented 5-HT-induced Akt activation.
Positive_regulation (induced) of Positive_regulation (activation) of Akt
4) Confidence 0.47 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.22
Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.
Positive_regulation (results) of Positive_regulation (activation) of Akt in dorsal horn associated with qutenza, dorsal horn and spinal cord
5) Confidence 0.46 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.30 Pain Relevance 0.55
At SW 3, p-PEA-15, a FADD-ERK binding partner, was also upregulated (51%) as well as the activation of its phosphorylating Akt1 kinase (49%).
Positive_regulation (upregulated) of Positive_regulation (activation) of Akt1
6) Confidence 0.41 Published 2010 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 19758790 Disease Relevance 0.06 Pain Relevance 0.74
These data show that MCT cells are a relevant model and confirm that phosphorylation and inactivation of tuberin via the redox-dependent activation of Akt play a major role in OGG1 downregulation and 8-oxodG accumulation.
Positive_regulation (role) of Positive_regulation (activation) of Akt
7) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.42 Pain Relevance 0
Akt phosphorylation on Ser 473 results in Akt activation, whereas phosphorylation of tuberin on Thr 1,462 results in its inactivation.
Positive_regulation (results) of Positive_regulation (activation) of Akt
8) Confidence 0.41 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.74 Pain Relevance 0
CONCLUSIONS—Hyperglycemia in type 1 diabetes and treatment of proximal tubular epithelial cells with high glucose leads to phosphorylation/inactivation of tuberin and downregulation of OGG1 via a redox-dependent activation of Akt in renal tubular epithelial cells.
Positive_regulation (inactivation) of Positive_regulation (activation) of Akt in epithelial cells associated with hyperglycemia and diabetes mellitus
9) Confidence 0.41 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2551671 Disease Relevance 0.38 Pain Relevance 0
The I/R hearts also showed markedly increased lactate dehydrogenase and creatine kinase activities in the coronary effluent, significant myocardial infarction (46% of risk area), and activation of Akt, extracellular signal-regulated kinase, and p38 mitogen-activated protein kinase.
Positive_regulation (increased) of Positive_regulation (activation) of Akt in hearts associated with myocardial infarction
10) Confidence 0.41 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16467453 Disease Relevance 0.69 Pain Relevance 0.29
A previous study revealed that essential components of the insulin signaling pathway upstream of the Akt kinase, such as insulin receptor ?
Positive_regulation (pathway) of Positive_regulation (upstream) of Akt kinase
11) Confidence 0.41 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.08 Pain Relevance 0.05
In addition, electrical stimulation of 'A and C' fibres in the sciatic nerve induced an increase in the cytoplasmic staining of p-Akt Ser 473 in small- and medium-size DRG neurons.
Positive_regulation (induced) of Positive_regulation (increase) of p-Akt Ser 473 in sciatic nerve associated with dorsal root ganglion and sciatic nerve
12) Confidence 0.40 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.51 Pain Relevance 0.68
Activation of peripheral nociceptors in vivo using intraplantar injections of capsaicin in anaesthetized rats induced a rapid onset and time-dependent increase in p-Akt Ser 473 in small- and medium-sized DRG, predominantly TRPV1-positive neurons.
Positive_regulation (induced) of Positive_regulation (increase) of p-Akt Ser 473 in neurons associated with dorsal root ganglion, qutenza and nociceptor
13) Confidence 0.40 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 15869474 Disease Relevance 0.50 Pain Relevance 0.56
Our data demonstrates that ultrasound-mediated BBB disruption causes an activation of the Akt signaling pathway in neuronal cells surrounding the disrupted BBB.



Positive_regulation (causes) of Positive_regulation (activation) of Akt in neuronal
14) Confidence 0.37 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Given that shear stress also triggers the activation of Akt in vascular endothelial cells [42], we might assume that ultrasound treatment triggers activation of Akt, leading to increased permeability of the endothelial cells.
Positive_regulation (triggers) of Positive_regulation (activation) of Akt in endothelial cells associated with stress
15) Confidence 0.37 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.20 Pain Relevance 0
Given that shear stress also triggers the activation of Akt in vascular endothelial cells [42], we might assume that ultrasound treatment triggers activation of Akt, leading to increased permeability of the endothelial cells.
Positive_regulation (triggers) of Positive_regulation (activation) of Akt in endothelial cells associated with stress
16) Confidence 0.37 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.19 Pain Relevance 0
Application of ultrasound results in activation of PI3kinase/Akt signaling pathway in neuronal cells.


Positive_regulation (results) of Positive_regulation (activation) of Akt in neuronal
17) Confidence 0.37 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0.22 Pain Relevance 0.06
Our data show that high glucose causes a rapid Akt-dependent increase in tuberin phosphorylation in MCT cells.
Positive_regulation (causes) of Positive_regulation (increase) of Akt-dependent
18) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2551671 Disease Relevance 0.17 Pain Relevance 0
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

Background

Positive_regulation (increase) of Positive_regulation (activation) of AKT
19) Confidence 0.32 Published 2010 Journal BMC Neurol Section Title Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0.05
Simvastatin, the Rho kinase inhibitor Y-27632, small interfering RNA-mediated RhoA gene silencing, and long-term 5-HT stimulation induced Akt activation.
Positive_regulation (induced) of Positive_regulation (activation) of Akt
20) Confidence 0.32 Published 2007 Journal J. Biol. Chem. Section Abstract Doc Link 17142836 Disease Relevance 0 Pain Relevance 0.23

General Comments

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