INT126751

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 10.84
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL10) extracellular region (IL10) intracellular (IL10)
cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
chondrocytes 6
monocyte 6
spinal 2
ganglia 2
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 304 100.00 Very High Very High Very High
Inflammation 233 100.00 Very High Very High Very High
Pain 30 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
agonist 24 98.16 Very High Very High Very High
opioid receptor 3 97.12 Very High Very High Very High
Osteoarthritis 111 96.76 Very High Very High Very High
Spinal cord 6 95.60 Very High Very High Very High
cINOD 5 93.52 High High
tolerance 14 85.28 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 273 100.00 Very High Very High Very High
Cancer 266 100.00 Very High Very High Very High
Osteoarthritis 36 100.00 Very High Very High Very High
Pain 31 100.00 Very High Very High Very High
Necrosis 25 100.00 Very High Very High Very High
Shock 15 100.00 Very High Very High Very High
Malaria 61 99.84 Very High Very High Very High
Infection 195 99.46 Very High Very High Very High
Neurocysticercosis 30 99.18 Very High Very High Very High
Neurodegenerative Disease 4 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Controlling pathological pain by adenovirally driven spinal production of the anti-inflammatory cytokine, interleukin-10.
Regulation (Controlling) of Gene_expression (production) of interleukin-10 in spinal associated with pain, inflammation and cytokine
1) Confidence 0.44 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 15869510 Disease Relevance 1.04 Pain Relevance 1.47
In our study, ESW application on isolated chondrocytes down-regulated the intracellular levels of TNF-alpha and IL-10, but no changes in ?
Regulation (intracellular) of Gene_expression (levels) of IL-10 in chondrocytes
2) Confidence 0.34 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.27 Pain Relevance 0.16
In our study, ESW application on isolated chondrocytes down-regulated the intracellular levels of TNF-alpha and IL-10, but no changes in ?
Regulation (regulated) of Gene_expression (levels) of IL-10 in chondrocytes
3) Confidence 0.34 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.27 Pain Relevance 0.16
levels without much effect on IL-10 expression in some of the patients who eventually relapsed.
Neg (without) Regulation (effect) of Gene_expression (expression) of IL-10
4) Confidence 0.33 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.26 Pain Relevance 0.04
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
Regulation (regulated) of Gene_expression (expression) of IL-10 in monocytes
5) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
Thus, the relationship between changes in HLA-DR expression and IL-10 levels could only be analyzed in AAS patients.
Regulation (changes) of Gene_expression (expression) of IL-10
6) Confidence 0.23 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.37
In this study, we evaluated the effects of morphine on tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-10 (IL-10) production in TLR2-stimulated human monocytes and identified the involvement of the different opioid receptors, and of the lymphocyte-to-monocyte contact.
Regulation (effects) of Gene_expression (production) of IL-10 in monocyte associated with necrosis, cancer, opioid receptor and morphine
7) Confidence 0.22 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18349186 Disease Relevance 0.35 Pain Relevance 0.35
In this study, we evaluated the effects of morphine on tumor necrosis factor (TNF), interleukin-6 (IL-6), and interleukin-10 (IL-10) production in TLR2-stimulated human monocytes and identified the involvement of the different opioid receptors, and of the lymphocyte-to-monocyte contact.
Regulation (effects) of Gene_expression (production) of interleukin-10 in monocyte associated with necrosis, cancer, opioid receptor and morphine
8) Confidence 0.22 Published 2008 Journal Anesth. Analg. Section Abstract Doc Link 18349186 Disease Relevance 0.35 Pain Relevance 0.35
The purpose of this study was to investigate the effects of extra corporeal shock waves (ESW) therapy on the metabolism of healthy and osteoarthritic human chondrocytes, and particularly on the expression of IL-10, TNF-alpha and beta1 integrin.


Spec (investigate) Regulation (effects) of Gene_expression (expression) of IL-10 in chondrocytes associated with shock and osteoarthritis
9) Confidence 0.21 Published 2008 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2268688 Disease Relevance 0.76 Pain Relevance 0.09
Increased IL10 levels have been detected repeatedly in human VL and are considered crucial in uncontrolled leishmanial infection [13, 14].
Regulation (considered) of Gene_expression (levels) of IL10 associated with infection
10) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2771279 Disease Relevance 0.71 Pain Relevance 0.12
However, the results observed with the other two infection models suggest a possible effect of the infective dose on IL-10 expression levels, higher levels being noted in animals infected with a high Leptospira dose (either virulent or not) when compared to their respective counterparts with the same outcome in the LD50 model.
Spec (possible) Regulation (effect) of Gene_expression (expression) of IL-10 associated with leptospirosis and infection
11) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 0.90 Pain Relevance 0.18
There is also some evidence that the neurodegenerative conditions are more common in individuals with SNPs of their IL-10 genes that modulate production of this cytokine.
Regulation (modulate) of Gene_expression (production) of IL-10 associated with neurodegenerative disease and cytokine
12) Confidence 0.17 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 1.63 Pain Relevance 0.24
Two hours after the start of CVVHD the median IL-10

concentration in the ultrafiltrate was 180 pg/ml (range 0?

Regulation (ultrafiltrate) of Gene_expression (concentration) of IL-10
13) Confidence 0.13 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 0.13 Pain Relevance 0
and increased levels of IL-4, IL-5, and IL-10, an effect that is thought to be mediated by decreasing IL-12 production thereby suggesting that ?
Regulation (effect) of Gene_expression (levels) of IL-10
14) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.58 Pain Relevance 0.54
However, the production of IL-10 and TGF-beta by Tregs has been challenged by others [56].
Regulation (challenged) of Gene_expression (production) of IL-10
15) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.41 Pain Relevance 0.32
IL-4 and IL-10 expression has been detected early during the infection in sensory ganglia of HSV-susceptible mouse strains [291].
Regulation (detected) of Gene_expression (expression) of IL-10 in ganglia associated with cold sores, sprains and strains and infection
16) Confidence 0.05 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.35 Pain Relevance 0.29
However, the level of IgE production was correlated to IL-10 levels in UM and AI patients (Figure 4).
Regulation (correlated) of Gene_expression (levels) of IL-10 associated with malaria
17) Confidence 0.03 Published 2007 Journal Malar J Section Body Doc Link PMC1781948 Disease Relevance 0.82 Pain Relevance 0.12
Consistent with this, the granulomatous response in human NCC has a strong immunoregulatory component involving the expression of IL-10 and TGF-?
Regulation (involving) of Gene_expression (expression) of IL-10 associated with neurocysticercosis
18) Confidence 0.03 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2274955 Disease Relevance 0.91 Pain Relevance 0.19

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